Identifying key circulating biomarkers that mediate the association between dynamic physical activity patterns and obesity risk

Deleted Journal, Год журнала: 2025, Номер 2(1)

Опубликована: Март 12, 2025

Язык: Английский

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A theoretical model of sports and health integration to promote active health

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Март 18, 2025

With the rising incidence of chronic diseases in China, national health management has become increasingly important. The integration sports and a strategic priority for promoting public improving nation's level. This study constructs theoretical model integration, exploring how scientific fitness can contribute to active health, especially within context "Healthy China" initiative. research proposes comprehensive framework that combines "12345 pyramid integration" with closed-loop service fitness. includes various elements such as knowledge learning, status assessments, specialized exercise training, monitoring, feedback, aiming promote lifelong physical activity optimize outcomes across different demographic groups. Promoting education disease significantly increased awareness Regular screenings assessments capacity help create personalized prescriptions, enhancing participation activities. feedback mechanism ensures continuous improvement levels supports long-term engagement healthy behaviors. presented this offers an actionable practical support implementation By integrating resources, technologies, interdisciplinary collaboration, enhance reduce burden diseases, provide solid foundation future policy industry development.

Язык: Английский

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Psychophysiological effects of a supervised home-based resistance band exercise program in pre-frail older patients with type 2 diabetes mellitus: a randomized controlled trial

BMC Sports Science Medicine and Rehabilitation, Год журнала: 2025, Номер 17(1)

Опубликована: Март 22, 2025

Frailty is a syndrome as with aging in the population of type 2 diabetes mellitus (T2DM) and exercise has become an essential non-pharmacological tool especially pre-frail stage. Notably, form supervised home-based program been strongly recommended recent years. This study aimed to verify potential effects elastic band older T2DM patients China. A total 100 participants were included randomly divided into intervention group (IG) (n = 50) control (CG) 50). The CG received routine care, while IG extra training under online offline supervisions sustaining 12-weeks. glycosylated hemoglobin (HbA1c), blood lipids, body composition, physical function, scales Diabetes specificity quality life scale (DSQL), Pittsburgh sleep index (PSQI) short geriatric depression (GDS-15) evaluated before after intervention. average age 66.01 ± 4.76 55% male BMI 24.75 3.51 kg/m2. clinical characteristics two groups comparable. After 12 weeks' training, muscle mass limbs (P < 0.05), function indicators including grip strength, chair stands (both P walking time 0.01), HbA1c frailty score subjective DSQL scores 0.01) depressive status improved significantly when compared CG. Supervised could improve limb mass, fitness, glucose lipid patients. ChiCTR2300070726; Registration date: 21/04/2023.

Язык: Английский

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Effects of a 16-week high-speed resistance training program on heart rate variability indices in community-dwelling independent older adults: A clinical trial

Journal of Applied Gerontology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

This study explored the impact of a 16-week high-speed resistance training (HSRT) program on heart rate variability (HRV) indices in independent older adults. The participants were divided into either an intervention group (IG, N = 40) or control (CG, 39). IG participated supervised HSRT sessions three times weekly, comprising 5–6 exercises with 2–3 sets and 6–10 repetitions, which lasted 60–70 min. CG did not engage any exercise program. HRV indices, encompassing time, frequency, non-linear, recorded over six-minute period. ANCOVA results revealed significant improvements favoring for mean RR (η 2 p 0.050), systolic blood pressure 0.126), pulse 0.157). Additionally, within-group analyses increases stress index ( d unb 0.52), sample entropy 0.38), DFA α1 0.38) exclusively CG. highlights potential to induce favorable changes parasympathetic activity reduce arterial stiffness.

Язык: Английский

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EFFECTS OF ACUTE AEROBIC AND RESISTANCE EXERCISE EXECUTION ORDER ON GLYCEMIA, BLOOD PRESSURE, AND HEART RATE VARIABILITY IN POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES MELLITUS: A RANDOMIZED CONTROLLED TRIAL

Journal of Bodywork and Movement Therapies, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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Comparative Efficacy of Different Exercise Modes on Inflammatory Markers in Patients With Type 2 Diabetes Mellitus: A Systematic Review With Pairwise and Network Meta‐Analyses

Obesity Reviews, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

Exercise training can reduce chronic low-grade inflammation; however, the most effective mode of exercise for lowering inflammation in patients with type 2 diabetes mellitus (T2D) is unknown. Therefore, we performed a systematic review pairwise and network meta-analyses to determine efficacy different modes improving T2D. A literature search was conducted PubMed, Web Science, Scopus from inception May 2024 using four main key words including "exercise," "cytokines," "type diabetes," "randomization." Randomized control or clinical trials investigating effects any mode, aerobic (AT), resistance (RT), AT + RT, high-intensity interval (HIIT), HIIT RT on inflammatory markers interleukin-6 (IL-6), TNF-α, C-reactive protein (CRP), leptin, adiponectin T2D were included. Standardized mean differences (SMD) 95% confidence intervals (CIs) calculated random models. Overall, 60 studies involving 3339 Compared control, effectively reduced IL-6 [SMD: -0.58], TNF-α -0.62], CRP -0.78], leptin -0.27], increased 0.35]. Based meta-analysis, IL-6, adiponectin; CRP, adiponectin. However, HIIT, did not change as compared controls. an approach T2D; specifically, appear be more than RT.

Язык: Английский

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Comparative effectiveness of different modes of exercise interventions in diabetics with frailty in China: a systematic review and a network meta-analysis

Diabetology & Metabolic Syndrome, Год журнала: 2024, Номер 16(1)

Опубликована: Фев. 26, 2024

Abstract Objective To systematically evaluate the efficacy of different training modes in patients with diabetes decline. Methods PubMed, Cochrane Library, EMbase, Web Science, CNKI, VIP, WANFANG, SinoMed were searched computer to collect randomized controlled trials (RCTs) intervention and frailty, search time was as May 21, 2023. After two review authors independently screened studies, extracted data, assessed risk bias included network meta-analysis performed using Stata14.0 R4.3.1 software. Fasting blood glucose (FGB), glycosylated haemoglobin (HbA1c), two-hour postprandial (PBG), total cholesterol (TCH), triglycerides (TG), low-density lipoprotein (LDL-C), Short Physical Performance Battery (SPPB), body mass index (BMI) used outcome measures. Results A 15 RCTs included, including 1550 patients. The results showed that integrated reduced FBG compared control group; training, Pilates resistance can reduce HbA1c; PBG; TCH; TG; improves BMI. best probability ranking multi-group had most significant effect on improving PBG SPPB scores. Conclusion current evidence suggests is way fasting improve physical activity before meals, may be glycated hemoglobin, hours after lipid level BMI China. Trial registration : PROSPERO number for this study: CRD42023427868.

Язык: Английский

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Effect of Low- and Moderate-Intensity Aerobic Training on Body Composition Cardiorespiratory Functions, Biochemical Risk Factors and Adipokines in Morbid Obesity

Nutrients, Год журнала: 2024, Номер 16(23), С. 4251 - 4251

Опубликована: Дек. 9, 2024

Background: Obesity poses an enormous public health and economic burden worldwide. Visceral fat accumulation is associated with various metabolic cardiovascular consequences, resulting in increased prevalence of atherosclerotic conditions. We aimed to examine the impact low-and moderate-intensity aerobic training on several anthropometric cardiorespiratory parameters markers atherosclerosis, including inflammation, serum levels lipoproteins adipokines extremely obese patients poor condition. Methods: Forty severely were recruited randomized into two groups, Group 1 2, for a six-week inpatient study. received (40–60% heart rate reserve) 2 low-intensity (30–39% combined resistance training. The patients’ functions assessed by ergospirometry. Anthropometric data recorded, body composition was analyzed functional tests performed. also investigated lipids high-sensitive C-reactive protein calculated homeostatic model assessment-insulin indices adipokine as predictive biomarkers. Results: Functional abilities some biochemical parameters, such resistance, lipids, apolipoprotein A apolipoprotein-B improved both groups positive direction. However, capacity Lipocalin-2 decreased, while irisin paraoxonase significantly, but only 1. Conclusions: Six weeks training, regardless its intensity, could induce favorable changes tests, even obese, unconditioned groups. should at least increase yield better lipid profile oxidative status inflammation profile.

Язык: Английский

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A novel periodized high‐repetition giant‐set resistance and high‐intensity interval training effects on the metabolic and pro‐inflammatory parameters in long‐ and short‐term overweight men

European Journal of Sport Science, Год журнала: 2024, Номер 24(1), С. 127 - 138

Опубликована: Янв. 1, 2024

Abstract This study compared the capacity of high‐repetition giant‐set resistance training (HGRT) and high‐intensity interval (HIIT) to decline C‐reactive protein (CRP), interleukin (IL)‐6, soluble IL‐6 receptor (SIL‐6R), IL‐18, insulin markers in long‐ (5–10 years) short‐term (1–4 overweight men. Another purpose was compare these between two populations. Firstly, eligible participants were matched based on age, body mass index, aerobic fitness then divided into a ( n = 37) or 32) population. After that, each category randomly assigned HGRT (2 giant sets 4‐exercise × 2 circuits at 30%–50% one‐repetition maximum with novel periodization), HIIT (4‐set 4‐min running 80%–90% HRmax), control (CON, non‐exercising) groups. The well‐balanced programs performed three weekly sessions for 12 weeks. showed that individuals longer history being have elevated baseline concentrations CRP, SIL‐6R, IL‐18 (all, p ≤ 0.04, effect size [ES] ≥0.65). Both led similar reduction homeostasis model assessment versus CON (all 0.03, ES ≥ 0.49) regardless duration overweight, although SIL‐6R significantly reduced after pretest (both, 0.17). exercises caused significant long‐term population CON, while only program decreased CRP 0.21 0.34). Thus, it seems plays crucial role deteriorating some biomarkers, greater potential attenuate IL‐18. However, might anti‐inflammatory (as indicated by SIL‐6R) than HGRT.

Язык: Английский

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Effects of 12-week Circuit Exercise Intervention on Blood Pressure, Vascular Function, and Inflammatory Cytokines in Obese Older Women with Sarcopenia

Reviews in Cardiovascular Medicine, Год журнала: 2024, Номер 25(5)

Опубликована: Май 22, 2024

Background: This study investigates the effects of a 12-week circuit exercise program on blood pressure, vascular function, and inflammatory cytokines in older obese women with sarcopenia. Methods: Twenty-eight sarcopenia (mean age: 78.2 ± 3.7 years) were randomly divided into an group (EG, n = 14) control (CG, 14). The EG participated training regimen, conducted three times weekly, each session lasting between 45 to 75 minutes (progressively increased over time). CG was advised maintain their regular daily routines throughout intervention period. All dependent variables, including inflammation cytokines, evaluated pre- post-intervention. Results: Positive changes observed body composition (body fat mass; p < 0.001, percentage; 0.01, free-fat 0.01), pressure (heart rate; 0.05, rate product; function (brachial–ankle pulse wave velocity; flow-mediated dilation; 0.001), (interleukin-6; 0.05). In CG, there increase mass (p 0.05) percentage 0.05), while no other variables. Conclusions: significantly reduced improved decreased However, individual variations response highlight need for personalized regimens.

Язык: Английский

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