HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation

Kidney International, Год журнала: 2018, Номер 95(2), С. 388 - 404

Опубликована: Дек. 11, 2018

Язык: Английский

---

The role of oxidative stress and hypoxia in renal disease

Kidney Research and Clinical Practice, Год журнала: 2019, Номер 38(4), С. 414 - 426

Опубликована: Сен. 27, 2019

Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are constantly released during mitochondrial consumption for energy production. Any imbalance between ROS production and its scavenger system induces oxidative stress. Oxidative stress, a critical contributor tissue damage, well-known be associated with various diseases. The kidney susceptible hypoxia, renal hypoxia common final pathway end stage disease, regardless of the underlying cause. Renal aggravates elevated in turn, exacerbates hypoxia. stress also enhanced chronic especially diabetic through mechanisms. Thus, vicious cycle critically contributes progression injury. This review examines recent evidence connecting disease subsequently describes several promising therapeutic approaches against Keywords: Hypoxia, Hypoxia-inducible factor, Nuclear factor erythroid 2-related 2, insufficiency,

Язык: Английский

---

Arterial spin labelling MRI to measure renal perfusion: a systematic review and statement paper

Nephrology Dialysis Transplantation, Год журнала: 2018, Номер 33(suppl_2), С. ii15 - ii21

Опубликована: Май 17, 2018

Renal perfusion provides the driving pressure for glomerular filtration and delivers oxygen nutrients to fuel solute reabsorption. ischaemia is a major mechanism in acute kidney injury may promote progression of chronic disease. Thus, quantifying renal tissue critically important both clinicians physiologists. Current reference techniques assessing have significant limitations. Arterial spin labelling (ASL) magnetic resonance imaging (MRI) technique that uses water arterial blood as an endogenous tracer generate maps absolute regional without requiring exogenous contrast. The holds enormous potential clinical use but remains restricted research settings. This statement paper from PARENCHIMA network briefly outlines ASL reviews data 53 studies published English through January 2018. by has been validated against methods good reproducibility. reduces with age excretory function. Technical advancements mean study can acquire whole measurement less than 5–10 min. short acquisition time permits combination other MRI might inform drug mechanisms physiology. flexibility yielded several variants technique, there are limited comparing these approaches. We make recommendations acquiring reporting outline knowledge gaps future should address.

Язык: Английский

---

Consensus-based technical recommendations for clinical translation of renal ASL MRI

Magnetic Resonance Materials in Physics Biology and Medicine, Год журнала: 2019, Номер 33(1), С. 141 - 161

Опубликована: Дек. 12, 2019

Abstract Objectives This study aimed at developing technical recommendations for the acquisition, processing and analysis of renal ASL data in human kidney 1.5 T 3 field strengths that can promote standardization perfusion measurements facilitate comparability results across scanners multi-centre clinical studies. Methods An international panel 23 experts followed a modified Delphi process, including on-line surveys two in-person meetings, to formulate series consensus statements regarding patient preparation, hardware, acquisition protocol, steps reporting. Results Fifty-nine achieved consensus, while agreement could not be reached on related preparation. As default recommends pseudo-continuous (PCASL) or flow-sensitive alternating inversion recovery (FAIR) labelling with single-slice spin-echo EPI readout background suppression simple but robust quantification model. Discussion approach is considered reproducible provide images adequate quality SNR most applications. If extended coverage desirable, 2D multislice recommended. These are based current available evidence expert opinion. Nonetheless they expected updated as more become available, since literature rapidly expanding.

Язык: Английский

---

Consensus-based technical recommendations for clinical translation of renal BOLD MRI

Magnetic Resonance Materials in Physics Biology and Medicine, Год журнала: 2019, Номер 33(1), С. 199 - 215

Опубликована: Ноя. 25, 2019

Abstract Harmonization of acquisition and analysis protocols is an important step in the validation BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on consensus report with aim to move towards standardized that facilitate clinical translation comparison data across sites. We used recently published systematic review paper, which included detailed summary parameters areas investigation its supplementary material, starting point developing survey questionnaires for seeking consensus. Survey were collected via Delphi process from 24 researchers exam preparation, acquisition, analysis, interpretation. Consensus was defined ≥ 75% unanimity response. Among 31 questions, 14 achieved resolution, 12 showed clear respondent preference (65–74% agreement), 5 equal (50/50%) split opinion among respondents. Recommendations subject processing reporting are given results literature. These aimed increased inter-site harmonization, first standardization expect this be iterative updated dynamically progress field.

Язык: Английский

---

Renal functional reserve: from physiological phenomenon to clinical biomarker and beyond

AJP Regulatory Integrative and Comparative Physiology, Год журнала: 2020, Номер 319(6), С. R690 - R702

Опубликована: Окт. 14, 2020

Glomerular filtration rate (GFR) is acutely increased following a high-protein meal or systemic infusion of amino acids. The mechanisms underlying this renal functional response remain to be fully elucidated. Nevertheless, they appear culminate in preglomerular vasodilation. Inhibition the tubuloglomerular feedback signal appears critical. However, nitric oxide, vasodilator prostaglandins, and glucagon also important. increase GFR during acid reveals “renal reserve,” which can utilized when physiological demand for single nephron increases. This has led concept that subclinical disease, before basal begins reduce, reserve recruited manner preserves function. extension once decline detected, disease already well progressed. likely applies both contexts chronic kidney acute injury. Critically, its corollary deficits have potential provide early detection dysfunction reduced. There growing evidence acids used identify patients at risk developing either injury as treatment target large multicenter clinical trials are required test these propositions. A renewed effort understand physiology warranted.

Язык: Английский

---

Uremic Toxins, Oxidative Stress, Atherosclerosis in Chronic Kidney Disease, and Kidney Transplantation

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Patients with chronic kidney disease (CKD) are at a high risk for cardiovascular (CVD), and approximately half of all deaths among patients CKD direct result CVD. The premature extends from mild to moderate stages, the severity CVD death increase decline in function. Successful transplantation significantly decreases relative long-term dialysis treatment; nevertheless, prevalence remains is responsible 20-35% mortality renal transplant recipients. traditional nontraditional factors higher recipients compared general population; however, it can only partly explain highly increased burden patients. Nontraditional factors, unique patients, include proteinuria, disturbed calcium, phosphate metabolism, anemia, fluid overload, accumulation uremic toxins. This toxins associated systemic alterations including inflammation oxidative stress which considered crucial progression CKD-related Kidney mitigate impact some these but they typically persist degree following transplantation. Taking into consideration scarcity data on waste products, stress, their relation atherosclerosis transplantation, review, we discussed vascular dysfunction Special attention was paid role native transplanted

Язык: Английский

---

Role of perioperative hypotension in postoperative acute kidney injury: a narrative review

British Journal of Anaesthesia, Год журнала: 2022, Номер 128(6), С. 931 - 948

Опубликована: Апрель 22, 2022

Язык: Английский

---

Renal blood flow and oxygenation

Pflügers Archiv - European Journal of Physiology, Год журнала: 2022, Номер 474(8), С. 759 - 770

Опубликована: Апрель 19, 2022

Our kidneys receive about one-fifth of the cardiac output at rest and have a low oxygen extraction ratio, but may sustain, under some conditions, hypoxic injuries that might lead to chronic kidney disease. This is due large regional variations in renal blood flow oxygenation, which are prerequisite for consequence other functions. The concurrent operation these functions reliant on multitude neuro-hormonal signaling cascades feedback loops also include regulation tissue oxygenation. Starting with open questions regulatory processes disease mechanisms, we review herein literature We assess current understanding regulation, reasons disparities delivery consumption, consequences disbalance between O

Язык: Английский

---

Hypoxia-Responsive Host–Guest Drug Delivery System

Accounts of Materials Research, Год журнала: 2023, Номер 4(11), С. 925 - 938

Опубликована: Окт. 9, 2023

ConspectusA host–guest drug delivery system (HGDDS) refers to a complex of an artificial receptor and therapeutic agent which can dissociate at the lesion site release loaded cargo. Macrocyclic receptors are promising carriers because their superior properties, including ease preparation, precise molecular weight, well-defined structure, excellent chemical stability. The loading process is mild, simple, repeatable. formulations quantitatively load exact cavity-loading pattern quantifiable binding constant. Host–guest typically modular, may be appealing in context personalized medicine macrocyclic act as platform diverse drugs. These lead good batch reproductivity application prospects both scientific research industry. However, order make HGDDS more suitable for practical application, several demands such high affinity, universal multiple drugs, targeting, stimuli-responsiveness still need considered.The hypoxia linked diseases biological processes, cancer, acute chronic diseases, pathogenic microbe infection, other stress responses. As part our ongoing on supramolecular biomaterials based macrocycles by taking advantage recognition assembly we have developed hypoxia-responsive azocalixarenes. azocalixarenes possess deepened cavity, resulting affinities encapsulation efficiencies toward agents. azo group one most frequently employed moieties it reduced under hypoxic microenvironments. This property confers with hypoxia-triggered due remarkable decrease following reduction. fast kinetics further facilitates efficient accumulation drugs site. azocalixarene-based HGDDSs been applied preclinical studies diagnosis treatment tumor, bacterial kidney injury, rheumatoid arthritis.In this Account, outline recent efforts designing formulating We first provide brief introduction HGDDSs, features, quantitative ratiometric models. Then design principles synthesis methods, strong loading, hypoxia-response described. applications treating different followed. Finally, despite rapid development there problems that solved scientifically terms clinical translation. Therefore, propose perspectives conducted HGDDSs.

Язык: Английский

---