Iron Metabolism and Ferroptosis in Diabetic Kidney Disease

Cell Biochemistry and Function, Год журнала: 2025, Номер 43(4)

Опубликована: Апрель 1, 2025

ABSTRACT Diabetic kidney disease (DKD) is a major diabetic microvascular complication that still lacks effective therapeutic drugs. Ferroptosis recently identified form of programmed cell death triggered by iron overload. It characterized unrestricted lipid peroxidation and subsequent membrane damage found in various diseases. Accumulating evidence has highlighted the crucial roles overload ferroptosis DKD. Here, we review metabolism biology ferroptosis. The role aberrant inducing diverse renal intrinsic death, oxidative stress, fibrosis DKD summarized, elaborate on critical regulatory factors related to Finally, focused significance treatment highlight recent data regarding novel activities some drugs as inhibitors DKD, aiming provide new research targets strategies

Язык: Английский

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The role of ferroptosis in acute kidney injury: mechanisms and potential therapeutic targets

Molecular and Cellular Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Июнь 28, 2024

Язык: Английский

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Costunolide Inhibits Chronic Kidney Disease Development by Attenuating IKKβ/NF-κB Pathway

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2693 - 2712

Опубликована: Июль 1, 2024

Chronic kidney disease (CKD) is a significant worldwide health concern that leads to high mortality rates. The bioactive substance costunolide (CTD) has demonstrated several pharmacological effects and holds promise as CKD treatment. This study aims investigate the impact of CTD on delve into its mechanisms action.

Язык: Английский

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Augmenter of liver regeneration inhibits renal fibrosis during acute kidney injury to chronic kidney disease transition by regulating autophagic flux

Archives of Biochemistry and Biophysics, Год журнала: 2024, Номер 764, С. 110218 - 110218

Опубликована: Ноя. 27, 2024

Язык: Английский

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