Prebiotics as modulators of colonic calcium and magnesium uptake DOI Creative Commons
Friederike Stumpff, David Manneck

Acta Physiologica, Год журнала: 2025, Номер 241(2)

Опубликована: Янв. 13, 2025

Ca2+ and Mg2+ are essential nutrients, deficiency can cause serious health problems. Thus, lack of lead to osteoporosis, with incidence rising both in absolute age-specific terms, while is associated type II diabetes. Prevention via vitamin D or estrogen controversial, the bioavailability from supplements significantly lower than that milk products. Problems likely increase as populations age number people on vegan diets surges. Developing new therapeutic strategies requires a better understanding molecular mechanisms involved absorption by intestinal epithelia. The vitamin-D dependent, active pathway for uptake upper small intestine involving TRPV6 highly efficient but only accounts about 20% total uptake. Instead, most thought occur passive paracellular diffusion across ileum, although sufficiently high luminal concentrations difficult achieve.. Interestingly, colon caecum also have considerable capacity Mg2+, which unclear. Intriguingly, stimulating fermentation prebiotics enhances colonic absorption, rise ~10% ~30% total. Notably, releases protons, inhibits channels selective (TRPV6 TRPM6/TRPM7). Conversely, non-selective cation channel TRPV3 stimulated intracellular acidification numerous herbal compounds. Spicy, fiber-rich food, traditionally consumed many cultures, might enhance this pathway.

Язык: Английский

Prebiotics as modulators of colonic calcium and magnesium uptake DOI Creative Commons
Friederike Stumpff, David Manneck

Acta Physiologica, Год журнала: 2025, Номер 241(2)

Опубликована: Янв. 13, 2025

Ca2+ and Mg2+ are essential nutrients, deficiency can cause serious health problems. Thus, lack of lead to osteoporosis, with incidence rising both in absolute age-specific terms, while is associated type II diabetes. Prevention via vitamin D or estrogen controversial, the bioavailability from supplements significantly lower than that milk products. Problems likely increase as populations age number people on vegan diets surges. Developing new therapeutic strategies requires a better understanding molecular mechanisms involved absorption by intestinal epithelia. The vitamin-D dependent, active pathway for uptake upper small intestine involving TRPV6 highly efficient but only accounts about 20% total uptake. Instead, most thought occur passive paracellular diffusion across ileum, although sufficiently high luminal concentrations difficult achieve.. Interestingly, colon caecum also have considerable capacity Mg2+, which unclear. Intriguingly, stimulating fermentation prebiotics enhances colonic absorption, rise ~10% ~30% total. Notably, releases protons, inhibits channels selective (TRPV6 TRPM6/TRPM7). Conversely, non-selective cation channel TRPV3 stimulated intracellular acidification numerous herbal compounds. Spicy, fiber-rich food, traditionally consumed many cultures, might enhance this pathway.

Язык: Английский

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