Hepatology Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 29, 2024
Abstract
Aim
Gamma‐glutamyltransferase
(GGT)
is
known
as
an
oxidative
stress
marker,
induced
by
alcohol
consumption
and
metabolic
disorders,
reported
a
predictor
of
hepatocellular
carcinoma
(HCC)
development
after
hepatitis
C
virus
(HCV)
elimination.
However,
it
not
clear
whether
GGT
serves
simply
surrogate
marker
for
overlapping
diseases
or
reflects
HCV‐specific
carcinogenicity.
We
investigated
the
association
between
hepatocarcinogenesis
achieving
sustained
viral
response
(SVR),
accounting
drinking
habits
diabetes,
examined
predisposing
factors
associated
with
levels
SVR.
Methods
This
prospective,
multicenter,
observational
study
using
database
1001
patients
HCV
eradication
direct‐acting
antiviral
agents.
The
at
SVR
cumulative
HCC
was
in
multivariate
analysis
Cox
proportional
hazard
models
adjustment
covariates
including
diabetes.
markers
genetic
analyzed.
Results
High
were
(HR]
2.38,
95%
CI
1.10–5.17).
also
significant
when
restricted
to
without
diabetes
(HR
8.38,
2.87–24.47).
correlated
serum
growth
differentiation
factor
15
levels,
mitochondrial
dysfunction.
Single‐nucleotide
polymorphisms
ZNF827
GDF15
high
levels.
Conclusions
are
influenced
predisposition
may
reflect
dysfunction
eradication.
Journal of Hepatology,
Год журнала:
2021,
Номер
76(4), С. 771 - 780
Опубликована: Дек. 9, 2021
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
highly
prevalent,
yet
largely
underappreciated
condition
which
closely
associated
with
obesity
and
metabolic
disease.
Despite
affecting
an
estimated
1
in
4
adults
globally,
NAFLD
absent
on
national
global
health
agendas.We
collected
data
from
102
countries,
accounting
for
86%
of
the
world
population,
policies,
guidelines,
civil
society
engagement,
clinical
management,
epidemiologic
data.
A
preparedness
index
was
developed
by
coding
questions
into
6
domains
(policies,
awareness,
epidemiology
data,
detection,
care
management)
categorising
responses
as
high,
medium,
low;
multiple
correspondence
analysis
then
applied.The
highest
scoring
countries
were
India
(42.7)
United
Kingdom
(40.0),
32
(31%)
zero
out
100.
For
5
minority
categorised
high-level
while
majority
low-level.
No
country
had
or
sub-national
strategy
<2%
different
strategies
related
conditions
included
any
mention
NAFLD.
National
guidelines
present
only
countries.Although
pressing
public
problem,
no
found
to
be
well
prepared
address
it.
There
need
at
levels.Around
third
scored
policy
index,
over
50/100.
Although
comprehensive
response
lacking
all
countries.
Policies
levels
are
urgently
needed.
Clinical and Molecular Hepatology,
Год журнала:
2021,
Номер
28(2), С. 150 - 163
Опубликована: Ноя. 10, 2021
Fatty
liver
is
now
a
major
cause
of
disease
in
the
Asia-Pacific
region.
Liver
diseases
this
region
have
distinctive
characteristics.
First,
fatty
frequently
observed
lean/normal-weight
individuals.
However,
there
no
standard
definition
unique
phenotype.
Second,
often
patients
with
concomitant
viral
hepatitis.
The
exclusion
hepatitis
from
non-alcoholic
limits
its
value
and
detracts
investigation
holistic
management
coexisting
Third,
liver-associated
hepatocellular
carcinoma
(HCC)
generally
categorized
as
non-B
non-C
HCC.
Fourth,
population
aging
rapidly,
it
imperative
to
develop
practicable,
low-intensity
exercise
program
for
elderly
patients.
Fifth,
most
nonspecialized
healthcare
professionals
still
lack
an
awareness
significance
both
terms
intrahepatic
extrahepatic
cancer.
Recently,
international
expert
panel
proposed
new
liver:
metabolic
dysfunction-associated
(MAFLD).
One
feature
MAFLD
that
dysfunction
prerequisite
diagnosis.
Pertinent
regional
issues,
also
provides
diagnostic
criteria
Furthermore,
independent
any
disease,
including
Therefore,
may
be
more
suitable
In
review,
we
introduce
characteristics
discuss
advantages
improving
clinical
practice
Current Opinion in Gastroenterology,
Год журнала:
2022,
Номер
38(3), С. 251 - 260
Опубликована: Фев. 9, 2022
Purpose
of
review
In
2020,
a
novel
comprehensive
redefinition
fatty
liver
disease
was
proposed
by
an
international
panel
experts.
This
aims
to
explore
current
evidence
regarding
the
impact
this
new
definition
on
understanding
epidemiology,
pathogenesis,
diagnosis,
and
clinical
trials
for
disease.
Recent
findings
The
effectiveness
metabolic
dysfunction-associated
(MAFLD)
compared
existing
criteria
nonalcoholic
(NAFLD).
data
robustly
suggest
superior
utility
MAFLD
in
identifying
patients
at
high
risk
dysfunction,
hepatic
extra-hepatic
complications,
as
well
those
who
would
benefit
from
genetic
testing,
including
with
concomitant
diseases.
change
name
also
appears
have
improved
awareness
among
physicians.
Summary
transformation
NAFLD
represents
important
milestone,
which
indicates
significant
tangible
progress
towards
more
inclusive,
equitable,
patient-centred
approach
addressing
profound
challenges
Growing
has
illustrated
broader
specific
contexts
that
tremendous
potential
positively
influencing
diagnosis
treatment.
addition,
momentum
accompanying
included
widespread
public
attention
unique
burden
previously
underappreciated
Journal of Gastroenterology,
Год журнала:
2023,
Номер
58(10), С. 947 - 964
Опубликована: Июль 20, 2023
Hepatocellular
carcinoma
has
a
substantial
global
mortality
burden
which
is
rising
despite
advancements
in
tackling
the
traditional
viral
risk
factors.
Metabolic
(dysfunction)
associated
fatty
liver
disease
(MAFLD)
most
prevalent
disease,
increasing
parallel
with
epidemics
of
obesity,
diabetes
and
systemic
metabolic
dysregulation.
MAFLD
major
factor
behind
this
sustained
rise
HCC
incidence,
both
as
single
entity
often
via
synergistic
interactions
other
diseases.
Mechanisms
MAFLD-related
are
complex
but
crucially
underpinned
by
dysregulation
variable
contributions
from
interacting
modifiers
related
to
environment,
genetics,
dysbiosis
immune
distinct
clinical
presentation,
notably
its
common
occurrence
non-cirrhotic
disease.
This
just
one
several
challenges
effective
surveillance
programmes.
The
response
immune-checkpoint
therapy
currently
controversial,
further
complicated
high
prevalence
individuals
aetiologies.
In
review,
we
highlight
current
data
on
epidemiology,
characteristics,
outcomes
screening
controversies.
addition,
concepts
that
have
arisen
because
paradigm
such
MAFLD/NAFLD
non-overlapping
groups,
dual
aetiology
tumours
sub-phenotypes
reviewed.
Saudi Journal of Gastroenterology,
Год журнала:
2022,
Номер
28(1), С. 3 - 20
Опубликована: Янв. 1, 2022
The
landscape
of
chronic
liver
disease
in
Egypt
has
drastically
changed
over
the
past
few
decades.
prevalence
metabolic-associated
fatty
(MAFLD)
risen
to
alarming
levels.
Despite
magnitude
problem,
no
regional
guidelines
have
been
developed
tackle
this
disease.
This
document
provides
clinical
practice
key
Egyptian
opinion
leaders
on
MAFLD
screening,
diagnosis,
and
management,
covers
various
aspects
management
MAFLD.
considers
our
local
situations
burden
for
healthcare
sector
is
proposed
daily
practical
use.
Particular
reference
special
groups
was
done
whenever
necessary.
