Bisphenols exposure and non-alcoholic fatty liver disease: from environmental trigger to molecular pathogenesis DOI Creative Commons

Changlei Li,

Zhi-Yuan Yao,

Yinfeng Zhang

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Май 22, 2025

Bisphenols (BPs), including bisphenol A (BPA) and its substitutes (BPS, BPF), are ubiquitous environmental contaminants with emerging links to metabolic disorders. This review synthesizes current evidence on the role of BP exposure in pathogenesis non-alcoholic fatty liver disease (NAFLD), a global health crisis affecting 25% adults worldwide. Epidemiological studies reveal significant positive associations between urinary/serum levels NAFLD risk, particularly males, maternal correlating transgenerational dysfunction. Mechanistically, BPs disrupt hepatic lipid homeostasis by activating PPAR-γ suppressing acid oxidation while concurrently inducing insulin resistance via impaired IRS-1/PI3K/Akt signaling. Oxidative stress, NLRP3 inflammasome activation, gut-liver axis perturbations further exacerbate steatosis inflammation. Co-exposure phthalates or high-fat diets amplifies hepatotoxicity, highlighting synergistic risks. Critically, developmental sex-specific susceptibility underscores need for tailored interventions. We propose preventive strategies mitigate progression, avoidance policy reforms. work bridges gaps epidemiology molecular toxicology, emphasizing as modifiable drivers disease.

Язык: Английский

Machine learning models for predicting metabolic dysfunction-associated steatotic liver disease prevalence using basic demographic and clinical characteristics DOI Creative Commons

Gangfeng Zhu,

Yipeng Song, Zenghong Lu

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Март 28, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern that necessitates early screening and timely intervention to improve prognosis. The current diagnostic protocols for MASLD involve complex procedures in specialised medical centres. This study aimed explore the feasibility of utilising machine learning models accurately screen large populations based on combination essential demographic clinical characteristics. A total 10,007 outpatients who underwent transient elastography at First Affiliated Hospital Gannan Medical University were enrolled form derivation cohort. Using eight characteristics (age, educational level, height, weight, waist hip circumference, history hypertension diabetes), we built predictive (classified as none or mild: controlled attenuation parameter (CAP) ≤ 269 dB/m; moderate: 269-296 severe: CAP > 296 dB/m) employing 10 algorithms: logistic regression (LR), multilayer perceptron (MLP), extreme gradient boosting (XGBoost), bootstrap aggregating, decision tree, K-nearest neighbours, light machine, naive Bayes, random forest, support vector machine. These externally validated using National Health Nutrition Examination Survey (NHANES) 2017-2023 datasets. In hospital outpatient cohort, algorithms demonstrated robust capabilities. Notably, LR achieved highest accuracy (ACC) 0.711 test cohort 0.728 validation coupled with areas under receiver operating characteristic curve (AUC) values 0.798 0.806, respectively. Similarly, MLP XGBoost showed promising results, achieving an ACC 0.735 registering AUC 0.798. External NHANES datasets yielded consistent (0.831), (0.823), (0.784) performing robustly. constructed can general population. approach significantly enhances feasibility, accessibility, compliance provides effective tool large-scale assessments strategies.

Язык: Английский

Процитировано

0
Schematic Assessment of Metabolic Signatures of Non-alcoholic Fatty Liver Disease by Bridging Endocrinology and Internal Medicine: A Precision Therapy-Based Meta-Analysis DOI Open Access
Sakina Abbas,

Zeeshan Hussain,

Nek Bakht Asghar

и другие.

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Non-alcoholic fatty liver disease (NAFLD) is seen as a health concern globally and identified via complex interactions of metabolic dysfunctions. Metabolomic lipidomic profiling has been emerged promising tool for non-invasive diagnosis precision therapy. This systematic review meta-analysis aimed to assess the affect signatures associated with NAFLD progression their utility in paving path medicine. A comprehensive literature search was conducted adherence guidelines Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) 2020. Appropriate data studies were pooled check using random effects model. Risk bias certainty evidence assessed Cochrane risk tool, ROBINS-I ("Risk Of Bias In Non-randomized Studies - Interventions"), Grading Recommendations, Assessment, Development Evaluation (GRADE) framework respectively. found distinct metabolite patterns especially amino acids, lipids, gut-derived metabolites that correlated severity NAFLD. The findings revealed hazard ratio 0.98 (95% CI: 0.83-1.15) indicated no significant association between assessment link progression. High heterogeneity observed (I² = 82%). generally low moderate, but overall rated moderate due inconsistency imprecision. Metabolic offered valuable insights discoveries into pathophysiology stratification. However, high across limited current clinical applicability. Standardized methodologies longitudinal validation needed combine care.

Язык: Английский

Процитировано

0
Polychlorinated Biphenyl Exposure Alters tRNA Transcriptome in High-Fat Diet-Fed Mouse Liver DOI Creative Commons
Carolyn M. Klinge, Julia H. Chariker, Kellianne M. Piell

и другие.

Non-Coding RNA, Год журнала: 2025, Номер 11(3), С. 41 - 41

Опубликована: Май 22, 2025

Background/Objectives: Exposure of high-fat diet (HFD)-fed mice to polychlorinated biphenyls (PCBs) results in metabolic dysfunction-associated steatotic liver disease (MASLD) and progression steatohepatitis (MASH). The mechanisms by which HFD PCBs increase MASLD are unclear. Previously, we identified differences HFD-fed mouse tRNA modifications with single oral exposures the dioxin-like PCB126, non-dioxin-like PCB mixture Aroclor 1260 (Ar1260), or combination Ar1260 + PCB126. Methods: Here, used small RNA sequencing analysis expression (tRAX) pipeline examine if alter transcriptome, including tRNA-derived fragments (tRFs), livers PCB-exposed mice. Results: Each exposure produced distinct hepatic transcriptomes more tRNAs decreased than increased. Only tRNA-Glu-TTC-1 was reduced all three exposures. More changes tRFs were alone PCB126 alone. Four tRF-3s upregulated both co-exposed mice, suggesting as responsible for this increase. We previously reported that increased Angiogenin (ANG) protein generates tRF-3s. corresponded positions PCB-associated tRAX: m1A, m6A, ms2t6A, Ψ. Conclusions: Overall, different suggest play an unexplored role regulating translation liver.

Язык: Английский

Процитировано

0
Bisphenols exposure and non-alcoholic fatty liver disease: from environmental trigger to molecular pathogenesis DOI Creative Commons

Changlei Li,

Zhi-Yuan Yao,

Yinfeng Zhang

и другие.

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Май 22, 2025

Bisphenols (BPs), including bisphenol A (BPA) and its substitutes (BPS, BPF), are ubiquitous environmental contaminants with emerging links to metabolic disorders. This review synthesizes current evidence on the role of BP exposure in pathogenesis non-alcoholic fatty liver disease (NAFLD), a global health crisis affecting 25% adults worldwide. Epidemiological studies reveal significant positive associations between urinary/serum levels NAFLD risk, particularly males, maternal correlating transgenerational dysfunction. Mechanistically, BPs disrupt hepatic lipid homeostasis by activating PPAR-γ suppressing acid oxidation while concurrently inducing insulin resistance via impaired IRS-1/PI3K/Akt signaling. Oxidative stress, NLRP3 inflammasome activation, gut-liver axis perturbations further exacerbate steatosis inflammation. Co-exposure phthalates or high-fat diets amplifies hepatotoxicity, highlighting synergistic risks. Critically, developmental sex-specific susceptibility underscores need for tailored interventions. We propose preventive strategies mitigate progression, avoidance policy reforms. work bridges gaps epidemiology molecular toxicology, emphasizing as modifiable drivers disease.

Язык: Английский

Процитировано

0