Pflügers Archiv - European Journal of Physiology, Год журнала: 2025, Номер unknown

Опубликована: Июнь 6, 2025

Abstract Cardiovascular function depends on an adequate vascular tone facilitating appropriate blood flow to individual tissues according their needs. The results from the interplay between vasodilatation and vasoconstriction. Its rapid efficient regulation is secured by many interconnected physiological mechanisms, both at level of smooth muscle endothelium. purpose this review provide update current knowledge mechanisms vasodilatation. First, two principal intracellular signaling pathways linked activation protein kinases PKA PKG are introduced. Subsequently, role endothelium-derived relaxing factors together with endothelium-dependent hyperpolarization discussed. roles ion channels gap junctions in communication endothelium cells particularly Finally, vasodilatory stimuli (mechanical, thermal, chemical) action briefly

Язык: Английский