Prescribing Patterns for the Treatment of Bipolar Disorder in Pregnancy: A Retrospective Cohort Study DOI Open Access

Nalinoë J. Kernizan,

Abigail M. Yancey,

Alicia B. Forinash

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(5), С. 1638 - 1638

Опубликована: Фев. 28, 2025

Background: Untreated bipolar disorder during pregnancy is associated with poor prenatal care, decreased fetal growth, and an increased risk for postnatal complications, including postpartum psychosis. Although mood stabilizers are first-line therapy, many patients providers discontinue them in early pregnancy. Antidepressants as monotherapy can increase the of mania rapid cycling, especially I, not recommended. Objective: This study aims to describe prescribing patterns pharmacologic management Methods: retrospective cohort included pregnant patients, ≥14 years old, a documented diagnosis ≥two clinic visits after 1 January 2014, who delivered by 31 October 2017, within our health system. Eligible were identified ICD-9 ICD-10 codes their medication profiles. The primary outcome was treatment regimens at first visit, pregnancy, delivery. Descriptive statistics used. Results: Of 214 pregnancies analyzed, 134 (62.6%) used psychiatric medications 79/134 (59%) being stabilizers. During initial 61/214 (28.5%) on medications, 30 (49.2%) 16 (26.2%) antidepressants alone. At delivery, 98/214 (45.8%) 48/98 (49%) 35/98 (35.7%) without Other therapies benzodiazepines, buspirone, amphetamines, or combination. Conclusions: Despite having disorder, only 30/214 (14%), 79/214 (36.9%), 48/214 (22.4%) treated respectively. Unfortunately, justification discontinuation documented. most commonly prescribed stabilizer lurasidone, followed lamotrigine. Antidepressant persisted throughout demonstrating inappropriate disease management.

Язык: Английский

Prescribing Patterns for the Treatment of Bipolar Disorder in Pregnancy: A Retrospective Cohort Study DOI Open Access

Nalinoë J. Kernizan,

Abigail M. Yancey,

Alicia B. Forinash

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(5), С. 1638 - 1638

Опубликована: Фев. 28, 2025

Background: Untreated bipolar disorder during pregnancy is associated with poor prenatal care, decreased fetal growth, and an increased risk for postnatal complications, including postpartum psychosis. Although mood stabilizers are first-line therapy, many patients providers discontinue them in early pregnancy. Antidepressants as monotherapy can increase the of mania rapid cycling, especially I, not recommended. Objective: This study aims to describe prescribing patterns pharmacologic management Methods: retrospective cohort included pregnant patients, ≥14 years old, a documented diagnosis ≥two clinic visits after 1 January 2014, who delivered by 31 October 2017, within our health system. Eligible were identified ICD-9 ICD-10 codes their medication profiles. The primary outcome was treatment regimens at first visit, pregnancy, delivery. Descriptive statistics used. Results: Of 214 pregnancies analyzed, 134 (62.6%) used psychiatric medications 79/134 (59%) being stabilizers. During initial 61/214 (28.5%) on medications, 30 (49.2%) 16 (26.2%) antidepressants alone. At delivery, 98/214 (45.8%) 48/98 (49%) 35/98 (35.7%) without Other therapies benzodiazepines, buspirone, amphetamines, or combination. Conclusions: Despite having disorder, only 30/214 (14%), 79/214 (36.9%), 48/214 (22.4%) treated respectively. Unfortunately, justification discontinuation documented. most commonly prescribed stabilizer lurasidone, followed lamotrigine. Antidepressant persisted throughout demonstrating inappropriate disease management.

Язык: Английский

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