Journal of Ultrasound in Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
This
study
aims
to
describe
the
ultrasound
characteristics
of
keratoacanthoma
(KA),
providing
valuable
insights
for
non-invasive
diagnosis
and
differentiation
from
well-differentiated
cutaneous
squamous
cell
carcinoma
(wcSCC).
Ultrasound
16
KA
13
wcSCC
conformed
by
surgical
pathology
were
retrospective
analyzed.
patients
younger
(mean
age
63.13
years)
compared
with
76.23
years).
revealed
that
lesions
generally
smaller,
more
frequently
domed-shaped
(87.50
vs
38.46%),
exophytic
(93.75
30.77%),
well-defined
53.85%)
wcSCC.
Both
lesion
types
predominantly
showed
hypoechoic
internal
echoes
inhomogeneous
echotexture.
The
prevalence
hyperechoic
superficial
area
was
notably
high
in
both
groups
84.62%),
precluding
reliable
use
this
feature
as
a
discriminatory
marker
between
these
two
distinct
neoplastic
entities.
mostly
confined
epidermis
dermis
(87.50%),
while
cases
infiltrated
into
subcutaneous
fat
layer
(84.62%).
Color
Doppler
imaging
demonstrated
higher
vascularity
lesions,
61.5%
showing
Grade
3
flow,
where
62.5%
exhibited
2
flow.
High-frequency
reveals
differentiating
wcSCC,
offering
promising
tool
preliminary
treatment
planning.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2220 - 2220
Опубликована: Фев. 13, 2024
Basal
cell
carcinoma
(BCC)
and
cutaneous
squamous
(cSCC)
are
the
most
frequently
occurring
non-melanocytic
skin
cancers.
The
objective
of
our
study
is
to
present
pathophysiology
BCC
cSCC
its
direct
relationship
with
histopathological
diagnostics
differential
these
types
cancer,
based
on
morphological
characteristics,
immunohistochemical
profile,
genetic
alterations.
qualitative
was
emphasizing
characteristics
immunohistochemistry
profiles
tissue
samples
from
Clinical
Pathology
Department
Mures
County
Hospital
between
2020
2022.
We
analyzed
appearances
in
comparison
those
Bowen
disease,
keratoacanthoma,
hyperkeratotic
papilloma,
metatypical
carcinoma,
pilomatricoma,
trichoblastoma,
Merkel
pleomorphic
dermal
sarcoma
(PDS),
melanoma.
Our
showed
importance
correct
diagnosis,
which
has
a
impact
appropriate
treatment
outcome
for
each
patient.
highlighted
NMSCs
precursor
lesions
HE
profile
that
may
make
diagnosis
difficult
establish.
Medicina,
Год журнала:
2024,
Номер
60(3), С. 371 - 371
Опубликована: Фев. 22, 2024
Keratoacanthoma
(KA)
is
a
fast-growing
skin
tumor
subtype
that
can
be
observed
as
solitary
lesion
or
rarely
multiple
lesions
in
the
context
of
rare
genetic
syndromes.
Syndromes
with
keratoacanthoma-like
have
been
documented
self-healing
squamous
epithelioma
(Ferguson–Smith
syndrome),
eruptive
keratoacanthoma
Grzybowski,
familial
Witten
and
Zak
Muir–Torre
syndrome,
incontinentia
pigmenti.
The
treatment
approach
those
entities
challenging
due
to
numerous
lesions,
lesions’
undefined
nature,
co-existence
other
malignant
tumors.
Herein,
we
report
case
40-year-old
woman
who
developed
treatment-resistant
Ferguson–Smith-like
keratoacanthomas
co-existing
large
ulcerated
invasive
cell
carcinoma
microcystic
adnexal
on
scalp.
Multiple
her
extremities
were
successfully
treated
oral
acitretin
(0.5
mg/kg/day)
combination
topical
Fluorouracil
(5-FU)
5%,
while
excision
plastic
surgery
restoration
performed
treat
cancer
Due
interesting
nature
this
literature
review
including
reports
series
multiple-KA-like
syndromes
focusing
diagnosis
therapy
approaches.
We
also
conducted
comparison
patient
reports,
which
included
assessing
clinical
appearance
evaluating
success
progress
failure
various
approaches
implemented.
Clinical Nuclear Medicine,
Год журнала:
2025,
Номер
50(5), С. e288 - e289
Опубликована: Апрель 3, 2025
Abstract
A
76-year-old
man
managed
for
stage
IV
advanced
melanoma
was
treated
with
nivolumab-ipilimumab,
complicated
by
corticotropic
insufficiency,
hypothyroidism,
and
rash.
At
first
evaluation,
18
F-FDG
PET/CT
clearly
showed
complete
metabolic
response
allowing
continued
treatment
nivolumab
alone.
6
months,
fully
confirmed
the
persistence
of
but
appearance
cutaneous
focal
uptakes
both
lateral
thighs
a
diffuse
uptake
on
lower
limbs.
Clinically,
he
had
severe
verrucous
lichenoid
eruption
eruptive
keratoacanthomas,
after
resection.
We
report
case
rare
immunotherapy-induced
keratoacanthomas
PET/CT.
Journal of Cosmetic Dermatology,
Год журнала:
2024,
Номер
23(6), С. 1936 - 1939
Опубликована: Апрель 4, 2024
Abstract
Background
Keratoacanthomas
(KAs)
following
laser
treatment
are
a
rare,
but
well‐described
entity.
Aim
Herein,
we
describe
case
of
eruptive
keratoacanthoma
(KA)
resurfacing
and
aim
to
better
characterize
laser‐associated
KAs.
Methods
A
literature
search
was
performed
on
PubMed
reviewing
KAs
including
various
characteristics:
epidemiology,
history
skin
cancer,
location,
number,
type
laser,
as
well
the
management
outcome.
Results
Fractional
ablative
most
common
triggering
KAs,
cases
presented
within
first
month
treatment.
The
majority
laser‐induced
KA
had
prior
malignant
or
premalignant
neoplasm.
Laser‐induced
were
treated
using
modalities
similar
arising
in
other
contexts.
Conclusion
Clinicians
need
be
knowledgeable
prepared
understand,
manage
complications
treatments,
rare
they
may
be,
Journal of Immunotherapy,
Год журнала:
2023,
Номер
47(3), С. 98 - 100
Опубликована: Ноя. 27, 2023
Immune
checkpoint
inhibitors
are
increasingly
being
utilized
for
the
treatment
of
advanced
neoplastic
disease
and
have
been
associated
with
wide-ranging
cutaneous
adverse
effects.
Though
exceedingly
rare,
eruptive
keratoacanthomas
use
immune
such
as
pembrolizumab
nivolumab,
whose
molecular
target
is
programmed
cell
death
protein
1.
Herein,
we
detail
a
case
numerous
arising
in
patient
one
month
after
initiation
nivolumab
recurrent
metastatic
oropharyngeal
squamous
carcinoma.
Treatment
multiple
rounds
intralesional
corticosteroids
several-month
course
oral
acitretin
resulted
partial
improvement.
Subsequent
5-fluorouracil
demonstrated
near-complete
resolution
without
discontinuation
nivolumab.
Although
secondary
to
exceptionally
physicians
should
be
aware
this
effect
their
becomes
more
widespread.
