Delving deeper into the pathogenesis and genomics of posttransplant diffuse large B‐cell lymphoma

HemaSphere, Год журнала: 2025, Номер 9(4)

Опубликована: Апрель 1, 2025

Abstract Posttransplant lymphoproliferative disorders (PTLDs) are a well‐known complication of solid organ transplantation and allogeneic hematopoietic stem cell transplantation. The diffuse large B‐cell lymphoma subtype (PT‐DLBCL) is the most frequent monomorphic PTLD associated with poor prognosis. Transplant recipients have an increased risk abnormal proliferation lymphoid cells because diminished immune surveillance. In about 60% cases, Epstein–Barr virus infection seems to contribute cancer phenotype. Although clinical research interest in disorder has during last two decades, pathology disease remains largely elusive. this review, we summarize current knowledge PT‐DLBCL pathogenesis, discuss how better understanding can lead improved diagnostics therapeutic strategies.

Язык: Английский

PDL1-expressing macrophages infiltrate diffuse large B-cell lymphoma and promote lymphoma growth in a MYC-driven experimental model

Blood Cancer Journal, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 16, 2025

Язык: Английский