Immunopharmacology and Immunotoxicology, Год журнала: 2024, Номер unknown, С. 1 - 22
Опубликована: Ноя. 27, 2024
Background Arsenic-trioxide (ATO) is an effective therapy for acute promyelocytic leukemia. Unfortunately, its utility hindered by the risk of myocardial injury. Both bisoprolol (BIS) and trimetazidine (TMZ) have various pharmacological features, including anti-oxidant, anti-inflammatory, anti-apoptotic properties.
Язык: Английский
Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)
Опубликована: Фев. 7, 2025
Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as critical intermediary. This review delineates the intricate pathways leading to mtDNA release, which include membrane permeabilization, vesicular trafficking, disruption homeostatic regulation, and abnormalities in dynamics. The escaped activates cytosolic sensors, especially cyclic gmp-amp synthase (cGAS) signalling inflammasome, initiating neuroinflammatory cascades via pathways, exacerbating spectrum neurological pathologies. therapeutic promise targeting discussed detail, underscoring necessity for multifaceted strategy that encompasses preservation homeostasis, prevention leakage, reestablishment dynamics, inhibition activation sensors. Advancing our understanding complex interplay between neuroinflammation imperative developing precision interventions disorders.
Язык: Английский
Процитировано
1
Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(4)
Опубликована: Фев. 1, 2025
ABSTRACT Fragile lungs or lung dysfunction can significantly impact a patient's quality of life. Currently, no specific treatment exists to prevent in elderly patients. The detailed mechanism fragile patients remains elusive, and this study aimed clarify it. General data blood specimens were obtained from with dysfunction. mice exposed cigarette smoke using smoking apparatus induce model. Blood samples tissues collected all groups for further testing. haematoxylin–eosin (HE) staining, immunofluorescence, Western blot, flow cytometry quantitative reverse transcriptase PCR (qRT‐PCR) used elucidate the molecular mechanisms multidimensional integrated protection measures (MILPM) by targeting AMP‐activated protein kinase (AMPK)/Sirtuin 1 (SIRT1) pathway. results indicated that upregulation AMPK/SIRT1 signalling pathway accelerates process, whereas downregulation Similarly, change forced vital capacity (FVC), total (TLC) levels is associated reducing their serve as preventative method against development. Upregulation accelerate process
Язык: Английский
Процитировано
0
Immunopharmacology and Immunotoxicology, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Фев. 27, 2025
Amikacin (AMC), an aminoglycoside antibiotic known for its rapid and potent bactericidal activity, is also associated with nephrotoxicity. Diosmin perindopril have been reported to improve renal function hold promise as therapeutic agents preventing drug-induced This study aimed investigate the protective effect of perindopril, either alone or in combination, against damage induced by AMC toxicity elucidate underlying mechanisms. The researchers evaluated impact (50 mg/kg, orally) (2 intraperitoneally) on AMC-induced kidney injury (1.2 g/kg, rats. Invasive blood pressure, serum parameters, oxidative stress biomarkers, inflammatory cytokine levels tissue were assessed. Histopathological changes examined using hematoxylin eosin (H&E) staining, electron microscopy, immunohistochemical analysis. molecular mechanisms combination pretreatment investigated enzyme-linked immunosorbent assay (ELISA) Western blotting techniques. findings demonstrated that therapy improved attenuating pathological observed H&E staining including tubular necrosis glomerular damage, addition reducing creatinine compared group, urea nitrogen (BUN) uric acid, albumin. Mean arterial markers Kidney Injury Molecule-1 (KIM-1), Cystatin-c decreased samples group group. Furthermore, downregulated NF-κB-p65, P53, Keap-1, C-FOS, while upregulating Mammalian sirtuin 1 (SIRT1), inhibitor nuclear factor kappa B (Iκβ), erythroid 2-related 2 (Nrf2), Heme oxygenase-1 (HO-1) levels. reveal potential clinical application combining reduce nephrotoxicity, which requires further research settings.
Язык: Английский
Процитировано
0
Human & Experimental Toxicology, Год журнала: 2024, Номер 43
Опубликована: Апрель 1, 2024
Purpose Drug-induced liver injury is becoming an increasingly important topic in drug research and clinical practice. Due to a lack of experimental animal models, predicting drug-induced humans challenging. Azathioprine (AZA) classical immunosuppressant with hepatotoxic adverse effects. The present study aimed address the hepatoprotective effect carvedilol (CAR) against AZA-induced hepatocellular via assessing redox-sensitive signals. Method To achieve this purpose, rats were allocated into four groups: control, CAR only, AZA plus groups. induction hepatic was induced by single intraperitoneal injection at dose 50 mg/kg on 6th day experiment. Each protocol approved supervised Ethics Committee for Animal Experiments. Results results revealed that administration significantly diminished dysfunction, as evidenced relief function biomarkers histopathological aberration injection. Besides, restored oxidant/antioxidant balance well NRF2 expression. In addition, suppressed inflammatory response challenge downregulation TLR4, TNF-α, MPO, eNOS/iNOS levels tissue. Moreover, recovered apoptotic/anti-apoptotic status modulation caspase-3/Bcl2 Conclusion Taken together, protects antioxidant, anti-inflammatory, anti-apoptotic activities. These findings could be good candidate protection can added therapeutic regimen reduce their effect.
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(22), С. e40473 - e40473
Опубликована: Ноя. 1, 2024
Arsenic can cause extensive toxic damage after entering the body of humans and animals by altering a variety events. As most common form methylation modification RNA in eukaryotic cells, N
Язык: Английский
Процитировано
0
Immunopharmacology and Immunotoxicology, Год журнала: 2024, Номер unknown, С. 1 - 22
Опубликована: Ноя. 27, 2024
Background Arsenic-trioxide (ATO) is an effective therapy for acute promyelocytic leukemia. Unfortunately, its utility hindered by the risk of myocardial injury. Both bisoprolol (BIS) and trimetazidine (TMZ) have various pharmacological features, including anti-oxidant, anti-inflammatory, anti-apoptotic properties.
Язык: Английский
Процитировано
0