Cannabinoid agonist WIN55,212-2 prevents scopolamine-induced impairment of spatial memory DOI
Marta Moreno‐Rodríguez, Iker Bengoetxea de Tena, Jonatan Martínez‐Gardeazabal

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Abstract The endocannabinoid system is involved in diverse processes, like learning and memory, governed by cholinergic neurotransmission. Recent research demonstrates that a model of dementia derived from basal forebrain degeneration, WIN55,212-2 improves cognition through increased cortical choline levels. However, the effect cannabinoids on deficits still under investigation. In this work, we studied treatment pharmacological transient hypofunction acute administration muscarinic antagonist, scopolamine, spatial, recognition aversive memory tests. Scopolamine induced impairment was observed three tests and, importantly, cannabinoid subchronic with low doses prevented deleterious spatial when evaluated Barnes maze test. Autoradiographic studies indicate that, following treatment, receptor density motor somatosensory cortices. layers I-V cortex, activity receptors also increased. These results suggest WIN55,212-2, activation CB 1 receptors, indirectly elevates tone key areas for preventing scopolamine specifically memory. This highlights importance crosstalk between processes agonists might be an alternative cognitive associated dysfunction.

Язык: Английский

Choline alleviates cognitive impairment in sleep-deprived young mice via reducing neuroinflammation and altering phospholipidomic profile DOI Creative Commons
Siyu Huang, Zhijun Yang, Jin Cheng

и другие.

Redox Biology, Год журнала: 2025, Номер 81, С. 103578 - 103578

Опубликована: Март 1, 2025

Cognitive impairment resulting from insufficient sleep poses a significant public health concern, particularly in children. The effects and mechanisms of choline on cognitive caused by deprivation are unknown. Chronic is induced young mice this study, followed feeding diet containing 11.36 g/kg bitartrate. Choline supplementation significantly improves spatial learning ability. Functional MRI results reveal the hippocampus as key region affected deprivation, where notably preserves hippocampal structural integrity enhanced connectivity. Additionally, ameliorates pathological injury, reduces blood-brain barrier permeability serum brain injury biomarkers. also inflammation oxidative stress biomarkers, mitigates microglial activation hippocampus, which synaptic plasticity. A finding changes phospholipidomic profile along with function, total 313 phospholipid molecules identified. increases levels sub-classes (particularly PC), strongly correlated reduced neuroinflammation well improved outcomes. Furthermore, there similar findings some such PC 36:1, O-33:0, p-38:3, PE 36:3, p-42:4 PS 44:12. These highlight that alleviates via reducing altering profile. This study suggests could develop into functional food or medicine ingredient to prevent treat disturbances, children adolescents.

Язык: Английский

Процитировано

1
Cannabinoid agonist WIN55,212-2 prevents scopolamine-induced impairment of spatial memory in rats DOI Creative Commons
Marta Moreno‐Rodríguez, Iker Bengoetxea de Tena, Jonatan Martínez‐Gardeazabal

и другие.

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177612 - 177612

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Synthesis and Pharmacological Characterization of a Novel Cannabinoid Receptor 1 Antagonist DOI Creative Commons
Iker Bengoetxea de Tena, Gorka Pereira‐Castelo, Jonatan Martínez‐Gardeazabal

и другие.

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Июнь 2, 2025

Язык: Английский

Процитировано

0
Cannabinoid agonist WIN55,212-2 prevents scopolamine-induced impairment of spatial memory DOI
Marta Moreno‐Rodríguez, Iker Bengoetxea de Tena, Jonatan Martínez‐Gardeazabal

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Abstract The endocannabinoid system is involved in diverse processes, like learning and memory, governed by cholinergic neurotransmission. Recent research demonstrates that a model of dementia derived from basal forebrain degeneration, WIN55,212-2 improves cognition through increased cortical choline levels. However, the effect cannabinoids on deficits still under investigation. In this work, we studied treatment pharmacological transient hypofunction acute administration muscarinic antagonist, scopolamine, spatial, recognition aversive memory tests. Scopolamine induced impairment was observed three tests and, importantly, cannabinoid subchronic with low doses prevented deleterious spatial when evaluated Barnes maze test. Autoradiographic studies indicate that, following treatment, receptor density motor somatosensory cortices. layers I-V cortex, activity receptors also increased. These results suggest WIN55,212-2, activation CB 1 receptors, indirectly elevates tone key areas for preventing scopolamine specifically memory. This highlights importance crosstalk between processes agonists might be an alternative cognitive associated dysfunction.

Язык: Английский

Процитировано

0