The tandem–random transition of cellular patterning: Roles of N-cadherin-based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Янв. 25, 2024

Abstract Intervertebral disc (IVD) degeneration can cause low back and neck pain. In IVD degeneration, the most affected component of IVDs is nucleus pulposus (NP). Derived from notochord, where cells organize into a tandem configuration, NP contains clustered in 3-dimensional (3D) networks embedded gelatinous matrix. Here, we summarize current understanding development, homeostasis, physiology, as well roles cell adhesion molecule N-cadherin these processes. We hypothesize that contributes to architectural transition notochord by switching mediating orientational adhesions (OCAs) random OCAs. The 3D clustering may facilitate act mechanosensor modulate gene expression under mechanical stresses. also highlight some open questions on functions NP. Answering helps with developing measures prevent treat degeneration.

Язык: Английский

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Molecular and morphogenetic features of neurulation

Zaporozhye Medical Journal, Год журнала: 2024, Номер 26(1), С. 72 - 77

Опубликована: Фев. 5, 2024

Neurulation occurs by two different mechanisms, called primary and secondary neurulation. In humans, neurulation along most of the rostrocaudal axis embryo, while caudally, only in lower sacral coccygeal regions. Primary is responsible for a change neural plate shape, lateral edges which rise then converge at dorsal midline to merge into tube. Initially, tube, formed as result neurulation, open both ends through so-called rostral caudal neuropores. These neuropores connect inner part tube with environment (amniotic cavity) later (by end neurulation) are closed. During brain spinal cord up upper region (up level junction between S1 S2 vertebral bodies), however, this anatomical (sacral-coccygeal division cord, conus medullaris filum terminale) due elongation cavitation cell mass medulla, transforms Thus, main differences that folds invaginates body embryo separates from surface ectoderm, forming an underlying hollow Mesenchymal сlusters form dense undergoes mesenchymal-epithelial transition forms cavities empty during terminal cord. Conclusions. Understanding detailed molecular genetic mechanisms each stage relevant widespread congenital defects, perfect knowledge on aspect all possible factors potential influence it will help develop modern options influencing some them, probably, cause decrease defects.

Язык: Английский

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The Lego hypothesis of tissue morphogenesis: stereotypic organization of parallel orientational cell adhesions for epithelial self‐assembly

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

How tissues develop distinct structures remains poorly understood. We propose herein the Lego hypothesis of tissue morphogenesis, which states that during topographical properties cell surface adhesion molecules can be dynamically altered and polarised by regulating spatiotemporal expression localization orientational (OCA) cell-autonomously non-cell-autonomously, thus modulating cells into unique pieces for self-assembling cytoarchitectures. This concept exemplified epithelial in are coalesced a sheet many types adhesions. Among them, parallel OCAs (pOCAs) at lateral membranes essential configuring parallel. Major pOCAs include Na

Язык: Английский

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Issue Information

Biological reviews/Biological reviews of the Cambridge Philosophical Society, Год журнала: 2023, Номер 98(6)

Опубликована: Ноя. 5, 2023

The journal aims to cover the whole field of biology, in particular growth areas modern biology.Articles range from comprehensive reviews a broad research shorter articles on more specialised topics, and very great flexibility content presentation is allowed.Articles are pitched at level for experts research, but

Язык: Английский

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