Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Дек. 23, 2024
Burgeoning
study
of
host-associated
microbiomes
has
accelerated
the
development
microbial
therapies,
including
fecal
microbiota
transplants
(FMTs).
FMTs
provide
host-specific
supplementation,
with
applicability
across
host
species.
Studying
can
simultaneously
comparative
frameworks
for
understanding
therapies
in
diverse
systems
and
improve
health
managed
wildlife.
Ex-situ
carnivores,
cheetahs
(Acinonyx
jubatus),
often
suffer
from
intractable
gut
infections
similar
to
those
treated
antibiotics
humans,
providing
a
valuable
system
testing
FMT
efficacy.
Using
an
experimental
approach
21
cheetahs,
we
tested
whether
autologous
facilitated
post-antibiotic
recovery
microbiota.
We
used
16S
rRNA
sequencing
source
tracking
characterize
antibiotic-induced
extirpations
signatures
engraftment
single
versus
multiple
FMTs.
found
that
extirpated
abundant
bacteria
quickened
via
may
facilitate
protein
digestion
butyrate
production
(Fusobacterium).
Although
better
sustained
compared
FMT,
one
improved
alone.
This
elucidated
dynamics
microbiome
modulation
non-model
improves
foundations
reproducible,
low-cost,
low-dose,
minimally
invasive
protocols,
emphasizing
scientific
applied
value
Autologous
recouping
composition
engrafting
specific
taxa.
elucidate
host-microbe
animal
care.
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Фев. 23, 2024
Abstract
Reproductive
microbiomes
contribute
to
reproductive
health
and
success
in
humans.
Yet
data
on
microbiomes,
links
fertility,
are
absent
for
most
animal
species.
Characterizing
these
is
pertinent
endangered
species,
such
as
black-footed
ferrets
(
Mustela
nigripes
),
whose
populations
show
dysfunction
rely
ex-situ
conservation
husbandry.
To
understand
microbial
contributions
success,
we
used
16S
rRNA
amplicon
sequencing
characterize
male
(prepuce)
female
(vaginal)
of
59
at
two
facilities
the
wild.
We
analyzed
variation
microbiome
structure
according
markers
fertility
numbers
viable
non-viable
offspring
(females)
sperm
concentration
(males).
Ferret
vaginal
showed
lower
inter-individual
compared
prepuce
microbiomes.
In
both
sexes,
wild
harbored
potential
soil
bacteria,
perhaps
reflecting
their
fossorial
behavior
exposure
natural
Vaginal
females
that
produced
litters
had
greater
phylogenetic
diversity
distinct
composition
other
females.
males,
correlated
with
varying
abundances
bacterial
taxa
(e.g.,
Lactobacillus
mirroring
results
humans
highlighting
intriguing
dynamics.
across
host
species
foundational
understanding
biomarkers
augmenting
Abstract
The
convergence
of
microbiome
science
with
the
One
Health
principle
heralds
a
transformative
era
in
biology,
prioritizing
collective
well‐being
humans,
animals,
and
environment.
This
review
delves
into
intricate
dance
between
microbiomes
their
hosts,
revealing
profound
impact
on
health,
nutrient
cycles,
climate
change.
Championing
unified
approach
to
health
issues
across
diverse
kingdoms
life,
emerges
as
holistic
strategy,
underscored
by
proposed
universal
balance
theory,
“Balance
Dynamic
Factors.”
theory
spotlights
equilibrium
within
microbial
human‐animal‐environment
interactions,
offering
revolutionary
pathway
global
social
well‐being.
It
paves
way
for
disease
prevention,
equity,
sustainability,
all
which
are
purviews
balanced
ecological
system.
We
navigate
challenges
opportunities
this
integrative
approach,
culminating
call
action
incorporation
policies,
precision
medicine,
legislation,
eco‐health
projects,
education,
thereby
setting
stage
harmonious
coexistence
our
planet.
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 2, 2024
The
welfare
of
wild
animal
populations
is
critically
important
to
conservation,
with
profound
implications
for
ecosystem
health,
biodiversity,
and
zoonotic
disease
transmission.
Animal
typically
defined
as
the
accumulated
affective
mental
state
an
over
a
particular
time
period.
However,
assessment
in
poses
unique
challenges,
primarily
due
lack
universally
applicable
biomarkers.
This
perspective
explores
potential
role
gut
microbiome,
dynamic
non-invasive
biomarker,
novel
avenue
evaluating
animals.
through
interactions
host's
physiology,
behavior,
cognition,
offers
promising
opportunity
gain
insights
into
well-being
In
this
synthesis,
we
discuss
distinction
between
fitness
welfare,
complexities
assessing
populations,
linkages
microbiome
aspects
such
behavior
cognition.
We
lastly
elucidate
how
could
serve
valuable
tool
wildlife
managers,
yet
informative
window
As
nascent
field
evolves,
it
presents
opportunities
enhance
our
understanding
animals
contribute
preservation
ecosystems,
human
health.
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Дек. 23, 2024
Burgeoning
study
of
host-associated
microbiomes
has
accelerated
the
development
microbial
therapies,
including
fecal
microbiota
transplants
(FMTs).
FMTs
provide
host-specific
supplementation,
with
applicability
across
host
species.
Studying
can
simultaneously
comparative
frameworks
for
understanding
therapies
in
diverse
systems
and
improve
health
managed
wildlife.
Ex-situ
carnivores,
cheetahs
(Acinonyx
jubatus),
often
suffer
from
intractable
gut
infections
similar
to
those
treated
antibiotics
humans,
providing
a
valuable
system
testing
FMT
efficacy.
Using
an
experimental
approach
21
cheetahs,
we
tested
whether
autologous
facilitated
post-antibiotic
recovery
microbiota.
We
used
16S
rRNA
sequencing
source
tracking
characterize
antibiotic-induced
extirpations
signatures
engraftment
single
versus
multiple
FMTs.
found
that
extirpated
abundant
bacteria
quickened
via
may
facilitate
protein
digestion
butyrate
production
(Fusobacterium).
Although
better
sustained
compared
FMT,
one
improved
alone.
This
elucidated
dynamics
microbiome
modulation
non-model
improves
foundations
reproducible,
low-cost,
low-dose,
minimally
invasive
protocols,
emphasizing
scientific
applied
value
Autologous
recouping
composition
engrafting
specific
taxa.
elucidate
host-microbe
animal
care.
