Investigating the role of exosomal long non-coding RNAs in drug resistance within female reproductive system cancers DOI Creative Commons
Nooshafarin Shirani,

N. Abdi,

Matin Chehelgerdi

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Янв. 24, 2025

Exosomes, as key mediators of intercellular communication, have been increasingly recognized for their role in the oncogenic processes, particularly facilitating drug resistance. This article delves into emerging evidence linking exosomal lncRNAs to modulation resistance mechanisms cancers such ovarian, cervical, and endometrial cancer. It synthesizes current research findings on how these influence cancer cell survival, tumor microenvironment, chemotherapy efficacy. Additionally, review highlights potential therapeutic strategies targeting lncRNAs, proposing a new frontier overcoming By mapping interface resistance, this aims provide comprehensive understanding that could pave way innovative treatments improved patient outcomes female reproductive system cancers.

Язык: Английский

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics DOI Creative Commons
Rishav Kar, Rajib Dhar, Sayantanee Mukherjee

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2023, Номер 9(2), С. 577 - 594

Опубликована: Янв. 9, 2023

Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles derived from plasma membrane. The main activity exosomes is cellular communication. In cancer, play an important rolefrom two distinct perspectives, one related to carcinogenesis and other as theragnostic drug delivery tools. outer phospholipid membrane Exosome improves targeting efficiency. . Some vital features such biocompatibility, low toxicity, immunogenicity make it a more exciting system. Exosome-based new innovative approach cancer treatment. Exosome-associated biomarker analysis heralded era diagnostics in specific way. This Review focuses on exosome biogenesis, sources, isolation, interrelationship with exosome-related biomarkers, loading methods, exosome-based biomolecule delivery, advances limitations clinical settings studies. understanding will change diagnostic therapeutic future.

Язык: Английский

Процитировано

140

The Role of Exosomes and Their Applications in Cancer DOI Open Access

Yuju Zhou,

Ying Zhang, Huan Gong

и другие.

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(22), С. 12204 - 12204

Опубликована: Ноя. 11, 2021

Exosomes are very small extracellular vesicles secreted by multiple cell types and extensively distributed in various biological fluids. Recent research indicated that exosomes can participate regulating the tumor microenvironment impacting proliferation progression. Due to extensive enrollment cancer development, have become a focus of search for new therapeutic method cancer. be utilized delivery molecules, proteins RNAs target cells with high efficiency. Exosome-carried proteins, lipids nucleic acids being tested as promising biomarkers diagnosis prognosis, even potential treatment targets Moreover, different sources exhibit performances applications. In this review, we elaborate on specific mechanism which affect communication between tumors state diagnostic applications cancers.

Язык: Английский

Процитировано

125

The role of macrophage subtypes and exosomes in immunomodulation DOI Creative Commons
Abdulwahab Teflischi Gharavi,

Niloofar Asadi Hanjani,

Elaheh Movahed

и другие.

Cellular & Molecular Biology Letters, Год журнала: 2022, Номер 27(1)

Опубликована: Окт. 3, 2022

Abstract Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range features, involving migration, development, and organization cells. There is mounting evidence macrophage plays key role in initiation development diseases. This study aims give an overview polarization, their subtypes, importance alternatively activated M2 classically M1 responses pathological conditions. review provides insight on exosomes M1/M2-like potential as promising therapeutic candidate.

Язык: Английский

Процитировано

121

The role of Exosomal miRNAs in cancer DOI Creative Commons
Chuanyun Li, Tong Zhou, Jing Chen

и другие.

Journal of Translational Medicine, Год журнала: 2022, Номер 20(1)

Опубликована: Янв. 3, 2022

Exosomal miRNAs have attracted much attention due to their critical role in regulating genes and the altered expression of virtually all cancers affecting humans (Sun et al. Mol Cancer 17(1):14, 2018). modulate processes that interfere with cancer immunity microenvironment, are significantly involved tumor growth, invasion, metastasis, angiogenesis drug resistance. Fully investigating detailed mechanism occurrence development various could help not only treatment but also prevention malignant diseases. The current review highlighted recently published advances regarding cancer-derived exosomes, e.g., sorting delivery mechanisms for RNAs. cell-to-cell communication, impacting angiogenesis, metastasis multiple biological features, were discussed. Finally, potential exosomal as diagnostic prognostic molecular markers was summarized, well usefulness detecting resistance therapeutic agents.

Язык: Английский

Процитировано

108

Small extracellular vesicles in cancer DOI Creative Commons
Komal Abhange, Amy Makler, Yi Wen

и другие.

Bioactive Materials, Год журнала: 2021, Номер 6(11), С. 3705 - 3743

Опубликована: Апрель 7, 2021

Extracellular vesicles (EV) are lipid-bilayer enclosed in submicron size that released from cells. A variety of molecules, including proteins, DNA fragments, RNAs, lipids, and metabolites can be selectively encapsulated into EVs delivered to nearby distant recipient In tumors, through such intercellular communication, regulate initiation, growth, metastasis invasion tumors. Recent studies have found exhibit specific expression patterns which mimic the parental cell, providing a fingerprint for early cancer diagnosis prognosis as well monitoring responses treatment. Accordingly, various EV isolation detection technologies been developed research diagnostic purposes. Moreover, natural engineered also used drug delivery nanocarriers, vaccines, cell surface modulators, therapeutic agents targets. Overall, under intense investigation they hold promise pathophysiological translational discoveries. This comprehensive review examines latest trends over last five years, encompassing their roles pathophysiology, diagnostics therapeutics. aims examine full spectrum tumor-EV provide foundation enhance field. The topics discussed scrutinized this encompass techniques how these issues need overcome EV-based diagnostics, biology, biomarkers monitoring, targets, systems. We will challenges involved promote framework catalyzing scientific discovery innovation tumor-EV-focused research.

Язык: Английский

Процитировано

107

Long non-coding RNA mediated drug resistance in breast cancer DOI
Deepshikha Singh, Yehuda G. Assaraf, Rajesh N. Gacche

и другие.

Drug Resistance Updates, Год журнала: 2022, Номер 63, С. 100851 - 100851

Опубликована: Июль 1, 2022

Язык: Английский

Процитировано

99

Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy DOI Creative Commons
Reza Hosseini, Hamzeh Sarvnaz, Maedeh Arabpour

и другие.

Molecular Cancer, Год журнала: 2022, Номер 21(1)

Опубликована: Янв. 14, 2022

Abstract Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity. As important sentinels immune surveillance system, natural killer (NK) cells can recognize malignant very early and counteract the development metastasis without a need for additional activation. Based on this rationale, adoptive transfer ex vivo expanded NK cells/NK cell lines, such as NK-92 cells, has attracted great attention widely studied promising immunotherapy treatment. However, exploiting various strategies, including secretion exosomes, are able to subvert responses. This paper reviews cancer-induced impairments with mechanistic insights. The clinical significance potential approaches nullify effects discussed.

Язык: Английский

Процитировано

82

Microfluidics for detection of exosomes and microRNAs in cancer: State of the art DOI Creative Commons
Seyed Mojtaba Mousavi,

Seyed Mohammad Amin Mahdian,

Mohammad Saeid Ebrahimi

и другие.

Molecular Therapy — Nucleic Acids, Год журнала: 2022, Номер 28, С. 758 - 791

Опубликована: Апрель 27, 2022

Exosomes are small extracellular vesicles with sizes ranging from 30–150 nanometers that contain proteins, lipids, mRNAs, microRNAs, and double-stranded DNA derived the cells of origin. can be taken up by target cells, acting as a means cell-to-cell communication. The discovery these in body fluids their participation cell communication has led to major breakthroughs diagnosis, prognosis, treatment several conditions (e.g., cancer). However, conventional isolation evaluation exosomes microRNA content suffers high cost, lengthy processes, difficult standardization, low purity, poor yield. emergence microfluidics devices increased efficiency sieving, trapping, immunological separation volumes could provide improved detection monitoring involved cancer. Microfluidics techniques hold promise for advances development diagnostic prognostic devices. This review covers ongoing research on microRNAs biomarkers translation point-of-care clinical applications.

Язык: Английский

Процитировано

74

Skin-targeted delivery of extracellular vesicle-encapsulated curcumin using dissolvable microneedle arrays DOI Creative Commons
Saigopalakrishna S. Yerneni,

Ezgi Pinar Yalcintas,

Jason D. Smith

и другие.

Acta Biomaterialia, Год журнала: 2022, Номер 149, С. 198 - 212

Опубликована: Июль 6, 2022

Therapeutic benefits of curcumin for inflammatory diseases have been demonstrated. However, curcumin's potential as a clinical therapeutic has hindered due to its low solubility and stability in vivo. We hypothesized that hybrid carrier incorporates albumin-binding extracellular vesicle (EV) encapsulation could effectively address the current challenges delivery. further postulated using dissolvable microneedle arrays (dMNAs) local delivery curcumin-albumin-EVs (CA-EVs) control skin inflammation Mild sonication was used encapsulate albumin into EVs, resulting CA-EVs were integrated tip-loaded dMNAs. In vitro vivo studies performed assess stability, cellular uptake, anti-inflammatory bioactivity dMNA-delivered CA-EVs. Curcumin exhibited at least five-fold higher than naïve or curcumin-EVs without albumin. Incorporating dMNAs did not alter their uptake bioactivity. The dMNA embedded retained when stored room temperature 12 months. rat mice models, delivered suppressed significantly reduced lipopolysaccharide Imiquimod-triggered inflammation. conclude become an effective local-delivery strategy diseases. STATEMENT OF SIGNIFICANCE: introduce evaluate skin-targeted system synergistically combines association, extracellular-vesicle encapsulation, . vitro, curcumin-albumin encapsulated vesicles inhibit reverse LPS-triggered expression transcription factor NF-κB. integration does affect them physically functionally. Importantly, extend EV storage months with minimal loss demonstrate block mouse models.

Язык: Английский

Процитировано

74

Immunotherapy for hepatocellular carcinoma: Recent advances and future targets DOI
Su Jong Yu

Pharmacology & Therapeutics, Год журнала: 2023, Номер 244, С. 108387 - 108387

Опубликована: Март 21, 2023

Язык: Английский

Процитировано

47