Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Янв. 24, 2025
Exosomes,
as
key
mediators
of
intercellular
communication,
have
been
increasingly
recognized
for
their
role
in
the
oncogenic
processes,
particularly
facilitating
drug
resistance.
This
article
delves
into
emerging
evidence
linking
exosomal
lncRNAs
to
modulation
resistance
mechanisms
cancers
such
ovarian,
cervical,
and
endometrial
cancer.
It
synthesizes
current
research
findings
on
how
these
influence
cancer
cell
survival,
tumor
microenvironment,
chemotherapy
efficacy.
Additionally,
review
highlights
potential
therapeutic
strategies
targeting
lncRNAs,
proposing
a
new
frontier
overcoming
By
mapping
interface
resistance,
this
aims
provide
comprehensive
understanding
that
could
pave
way
innovative
treatments
improved
patient
outcomes
female
reproductive
system
cancers.
ACS Biomaterials Science & Engineering,
Год журнала:
2023,
Номер
9(2), С. 577 - 594
Опубликована: Янв. 9, 2023
Exosomes
are
the
phospholipid-membrane-bound
subpopulation
of
extracellular
vesicles
derived
from
plasma
membrane.
The
main
activity
exosomes
is
cellular
communication.
In
cancer,
play
an
important
rolefrom
two
distinct
perspectives,
one
related
to
carcinogenesis
and
other
as
theragnostic
drug
delivery
tools.
outer
phospholipid
membrane
Exosome
improves
targeting
efficiency.
.
Some
vital
features
such
biocompatibility,
low
toxicity,
immunogenicity
make
it
a
more
exciting
system.
Exosome-based
new
innovative
approach
cancer
treatment.
Exosome-associated
biomarker
analysis
heralded
era
diagnostics
in
specific
way.
This
Review
focuses
on
exosome
biogenesis,
sources,
isolation,
interrelationship
with
exosome-related
biomarkers,
loading
methods,
exosome-based
biomolecule
delivery,
advances
limitations
clinical
settings
studies.
understanding
will
change
diagnostic
therapeutic
future.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(22), С. 12204 - 12204
Опубликована: Ноя. 11, 2021
Exosomes
are
very
small
extracellular
vesicles
secreted
by
multiple
cell
types
and
extensively
distributed
in
various
biological
fluids.
Recent
research
indicated
that
exosomes
can
participate
regulating
the
tumor
microenvironment
impacting
proliferation
progression.
Due
to
extensive
enrollment
cancer
development,
have
become
a
focus
of
search
for
new
therapeutic
method
cancer.
be
utilized
delivery
molecules,
proteins
RNAs
target
cells
with
high
efficiency.
Exosome-carried
proteins,
lipids
nucleic
acids
being
tested
as
promising
biomarkers
diagnosis
prognosis,
even
potential
treatment
targets
Moreover,
different
sources
exhibit
performances
applications.
In
this
review,
we
elaborate
on
specific
mechanism
which
affect
communication
between
tumors
state
diagnostic
applications
cancers.
Cellular & Molecular Biology Letters,
Год журнала:
2022,
Номер
27(1)
Опубликована: Окт. 3, 2022
Abstract
Macrophages
are
influential
members
of
the
innate
immune
system
that
can
be
reversibly
polarized
by
different
microenvironment
signals.
Cell
polarization
leads
to
a
wide
range
features,
involving
migration,
development,
and
organization
cells.
There
is
mounting
evidence
macrophage
plays
key
role
in
initiation
development
diseases.
This
study
aims
give
an
overview
polarization,
their
subtypes,
importance
alternatively
activated
M2
classically
M1
responses
pathological
conditions.
review
provides
insight
on
exosomes
M1/M2-like
potential
as
promising
therapeutic
candidate.
Journal of Translational Medicine,
Год журнала:
2022,
Номер
20(1)
Опубликована: Янв. 3, 2022
Exosomal
miRNAs
have
attracted
much
attention
due
to
their
critical
role
in
regulating
genes
and
the
altered
expression
of
virtually
all
cancers
affecting
humans
(Sun
et
al.
Mol
Cancer
17(1):14,
2018).
modulate
processes
that
interfere
with
cancer
immunity
microenvironment,
are
significantly
involved
tumor
growth,
invasion,
metastasis,
angiogenesis
drug
resistance.
Fully
investigating
detailed
mechanism
occurrence
development
various
could
help
not
only
treatment
but
also
prevention
malignant
diseases.
The
current
review
highlighted
recently
published
advances
regarding
cancer-derived
exosomes,
e.g.,
sorting
delivery
mechanisms
for
RNAs.
cell-to-cell
communication,
impacting
angiogenesis,
metastasis
multiple
biological
features,
were
discussed.
Finally,
potential
exosomal
as
diagnostic
prognostic
molecular
markers
was
summarized,
well
usefulness
detecting
resistance
therapeutic
agents.
Bioactive Materials,
Год журнала:
2021,
Номер
6(11), С. 3705 - 3743
Опубликована: Апрель 7, 2021
Extracellular
vesicles
(EV)
are
lipid-bilayer
enclosed
in
submicron
size
that
released
from
cells.
A
variety
of
molecules,
including
proteins,
DNA
fragments,
RNAs,
lipids,
and
metabolites
can
be
selectively
encapsulated
into
EVs
delivered
to
nearby
distant
recipient
In
tumors,
through
such
intercellular
communication,
regulate
initiation,
growth,
metastasis
invasion
tumors.
Recent
studies
have
found
exhibit
specific
expression
patterns
which
mimic
the
parental
cell,
providing
a
fingerprint
for
early
cancer
diagnosis
prognosis
as
well
monitoring
responses
treatment.
Accordingly,
various
EV
isolation
detection
technologies
been
developed
research
diagnostic
purposes.
Moreover,
natural
engineered
also
used
drug
delivery
nanocarriers,
vaccines,
cell
surface
modulators,
therapeutic
agents
targets.
Overall,
under
intense
investigation
they
hold
promise
pathophysiological
translational
discoveries.
This
comprehensive
review
examines
latest
trends
over
last
five
years,
encompassing
their
roles
pathophysiology,
diagnostics
therapeutics.
aims
examine
full
spectrum
tumor-EV
provide
foundation
enhance
field.
The
topics
discussed
scrutinized
this
encompass
techniques
how
these
issues
need
overcome
EV-based
diagnostics,
biology,
biomarkers
monitoring,
targets,
systems.
We
will
challenges
involved
promote
framework
catalyzing
scientific
discovery
innovation
tumor-EV-focused
research.
Abstract
Tumor-derived
exosomes
(TDEs)
play
pivotal
roles
in
several
aspects
of
cancer
biology.
It
is
now
evident
that
TDEs
also
favor
tumor
growth
by
negatively
affecting
anti-tumor
immunity.
As
important
sentinels
immune
surveillance
system,
natural
killer
(NK)
cells
can
recognize
malignant
very
early
and
counteract
the
development
metastasis
without
a
need
for
additional
activation.
Based
on
this
rationale,
adoptive
transfer
ex
vivo
expanded
NK
cells/NK
cell
lines,
such
as
NK-92
cells,
has
attracted
great
attention
widely
studied
promising
immunotherapy
treatment.
However,
exploiting
various
strategies,
including
secretion
exosomes,
are
able
to
subvert
responses.
This
paper
reviews
cancer-induced
impairments
with
mechanistic
insights.
The
clinical
significance
potential
approaches
nullify
effects
discussed.
Molecular Therapy — Nucleic Acids,
Год журнала:
2022,
Номер
28, С. 758 - 791
Опубликована: Апрель 27, 2022
Exosomes
are
small
extracellular
vesicles
with
sizes
ranging
from
30–150
nanometers
that
contain
proteins,
lipids,
mRNAs,
microRNAs,
and
double-stranded
DNA
derived
the
cells
of
origin.
can
be
taken
up
by
target
cells,
acting
as
a
means
cell-to-cell
communication.
The
discovery
these
in
body
fluids
their
participation
cell
communication
has
led
to
major
breakthroughs
diagnosis,
prognosis,
treatment
several
conditions
(e.g.,
cancer).
However,
conventional
isolation
evaluation
exosomes
microRNA
content
suffers
high
cost,
lengthy
processes,
difficult
standardization,
low
purity,
poor
yield.
emergence
microfluidics
devices
increased
efficiency
sieving,
trapping,
immunological
separation
volumes
could
provide
improved
detection
monitoring
involved
cancer.
Microfluidics
techniques
hold
promise
for
advances
development
diagnostic
prognostic
devices.
This
review
covers
ongoing
research
on
microRNAs
biomarkers
translation
point-of-care
clinical
applications.
Acta Biomaterialia,
Год журнала:
2022,
Номер
149, С. 198 - 212
Опубликована: Июль 6, 2022
Therapeutic
benefits
of
curcumin
for
inflammatory
diseases
have
been
demonstrated.
However,
curcumin's
potential
as
a
clinical
therapeutic
has
hindered
due
to
its
low
solubility
and
stability
in
vivo.
We
hypothesized
that
hybrid
carrier
incorporates
albumin-binding
extracellular
vesicle
(EV)
encapsulation
could
effectively
address
the
current
challenges
delivery.
further
postulated
using
dissolvable
microneedle
arrays
(dMNAs)
local
delivery
curcumin-albumin-EVs
(CA-EVs)
control
skin
inflammation
Mild
sonication
was
used
encapsulate
albumin
into
EVs,
resulting
CA-EVs
were
integrated
tip-loaded
dMNAs.
In
vitro
vivo
studies
performed
assess
stability,
cellular
uptake,
anti-inflammatory
bioactivity
dMNA-delivered
CA-EVs.
Curcumin
exhibited
at
least
five-fold
higher
than
naïve
or
curcumin-EVs
without
albumin.
Incorporating
dMNAs
did
not
alter
their
uptake
bioactivity.
The
dMNA
embedded
retained
when
stored
room
temperature
12
months.
rat
mice
models,
delivered
suppressed
significantly
reduced
lipopolysaccharide
Imiquimod-triggered
inflammation.
conclude
become
an
effective
local-delivery
strategy
diseases.
STATEMENT
OF
SIGNIFICANCE:
introduce
evaluate
skin-targeted
system
synergistically
combines
association,
extracellular-vesicle
encapsulation,
.
vitro,
curcumin-albumin
encapsulated
vesicles
inhibit
reverse
LPS-triggered
expression
transcription
factor
NF-κB.
integration
does
affect
them
physically
functionally.
Importantly,
extend
EV
storage
months
with
minimal
loss
demonstrate
block
mouse
models.
