Advances in Cancer Biology - Metastasis, Год журнала: 2025, Номер unknown, С. 100136 - 100136
Опубликована: Фев. 1, 2025
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(17), С. 9463 - 9463
Опубликована: Авг. 30, 2024
Colorectal cancer (CRC) represents a significant global health burden, with high incidence and mortality rates worldwide. Recent progress in research highlights the distinct clinical molecular characteristics of colon versus rectal cancers, underscoring tumor location's importance treatment approaches. This article provides comprehensive review our current understanding CRC epidemiology, risk factors, pathogenesis, management strategies. We also present intricate cellular architecture colonic crypts their roles intestinal homeostasis. carcinogenesis multistep processes are described, covering conventional adenoma-carcinoma sequence, alternative serrated pathways, influential Vogelstein model, which proposes sequential
Язык: Английский
Процитировано
9
Cancer Drug Resistance, Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
Gastrointestinal (GI) cancers are becoming a growing cause of morbidity and mortality globally, posing significant risk to human life health. The main treatment for this kind cancer is chemotherapy based on 5-fluorouracil (5-FU). However, the issue 5-FU resistance increasingly prominent, which greatly limits its effectiveness in clinical treatment. Recently, numerous studies have disclosed that some non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), exert remarkable physiological functions within cells. In addition, these ncRNAs can also serve as important information communication molecules tumor microenvironment regulate resistance. particular, they been shown play multiple roles regulating GI cancers. Herein, we summarize targets, pathways, mechanisms involved by briefly discuss application potential biomarkers or therapeutic targets cancers, aiming offer reference tackle issues related
Язык: Английский
Процитировано
1
European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177294 - 177294
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
APOPTOSIS, Год журнала: 2025, Номер unknown
Опубликована: Фев. 4, 2025
Colorectal cancer (CRC) represents a significant global health burden, with chemotherapy resistance representing challenge to effective treatment. SEC23A, core component of the COPII vesicle trafficking system, is critical importance regard protein transport and cellular homeostasis. Nevertheless, its function in CRC progression chemoresistance remains uncertain. The present study investigates correlation between SEC23A expression sensitivity 5-fluorouracil (5-FU), widely used chemotherapeutic agent, particular emphasis on ER stress-induced apoptosis. A bioinformatic analysis was conducted evaluate association patient prognosis. Chemotherapy predicted using GDSC data validated experimentally cell lines manipulated expression. In order explore role acquired drug resistance, patient-derived xenograft (PDX) models 5-FU-resistant were employed. Apoptosis assays, cycle analysis, stress modulation experiments performed elucidate underlying mechanisms. significantly reduced samples compared normal tissues. This reduction linked poorer prognosis, including both overall disease-specific survival. observed low increased 5-FU, as evidenced by predictions vitro experiments. PDX models, metastatic lesions exhibited decreased following 5-FU treatment comparison primary tumors. Overexpression restored Bioinformatic experimental analyses revealed robust stress-related apoptotic pathways. Elevated facilitate accumulation misfolded proteins response treatment, which turn resulted plays crucial modulating cells regulating Its downregulation contributes chemoresistance, indicating that may serve prognostic marker therapeutic target CRC. Strategies aimed at upregulating or enhancing provide new avenues for overcoming improving outcomes patients.
Язык: Английский
Процитировано
1
Advances in Cancer Biology - Metastasis, Год журнала: 2025, Номер unknown, С. 100136 - 100136
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1