Cancer Immunology Immunotherapy, Год журнала: 2023, Номер 72(12), С. 3953 - 3969
Опубликована: Ноя. 2, 2023
Язык: Английский
International Journal of Oncology, Год журнала: 2022, Номер 61(4)
Опубликована: Авг. 4, 2022
Pancreatic cancer (PC) is a lethal type of for which effective therapies are limited. Long non‑coding RNAs (lncRNAs) represent critical regulator category, mediating the tumorigenesis and development various tumor types, including PC. However, expression patterns functions numerous lncRNAs in PC remain poorly understood. In present study, linc01614 was identified as PC‑related lncRNA. notably upregulated tissues cell lines associated with poor disease‑free survival patients according to analysis The Cancer Genome Atlas‑derived datasets. Functionally, knockdown suppressed proliferation, migration invasion in vitro, inhibited proliferation vitro vivo. Mechanistically, overexpression stabilized level β‑catenin protein hyperactivate WNT/β‑catenin signaling pathway cells. Further analyses revealed that bound GSK‑3β perturbed interaction between AXIN1, thereby preventing formation degradation complex reducing β‑catenin. summary, findings reveal may function an oncogene promote progression thus be considered potential therapeutic target future.
Язык: Английский
Процитировано
15
Discover Oncology, Год журнала: 2025, Номер 16(1)
Опубликована: Март 28, 2025
Never-in-mitosis gene A-related-kinase-2 (NEK2) plays a pivotal role in malignant progression and chemotherapy sensitivity. This study aimed to elucidate the of NEK2 colorectal cancer (CRC) its potential contribution 5-fluorouracil (5‑FU) resistance mechanisms. Quantitative real-time PCR (qRT‑PCR), western blotting, immunohistochemical (IHC) staining were used assess expression CRC tissues cells. The effects 5‑FU on proliferation, apoptosis, migration, invasion cells investigated via Cell Counting Kit-8 (CCK-8), colony formation, flow cytometry, wound healing, transwell assays, respectively. Methyl 3-(4-methylphenylsulfonamido) benzoate (MSAB) was as Wnt/beta (β)-catenin pathway inhibitor this study. significantly upregulated compared normal controls. High correlated with advanced tumor-node-metastasis (TNM) stage, lymph node metastasis, distant poor tumor prognosis. overexpression promoted inhibited cytotoxic effect 5-FU nuclear accumulation β-catenin activated Wnt/β-catenin signaling pathway. MSAB reversed stimulatory upregulation proliferation In summary, promotes cell survival decreases sensitivity by activating Consequently, holds promise therapeutic target for management.
Язык: Английский
Процитировано
0
Neuropharmacology, Год журнала: 2025, Номер unknown, С. 110514 - 110514
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Biological Procedures Online, Год журнала: 2025, Номер 27(1)
Опубликована: Май 28, 2025
Язык: Английский
Процитировано
0
Neoplasma, Год журнала: 2022, Номер 69(06), С. 1253 - 1269
Опубликована: Янв. 1, 2022
Osteopontin (OPN) is a multifunctional phosphorylated glycoprotein that expressed at significantly elevated levels in various cancers.OPN overexpression closely associated with the development of cancer progression such as proliferation, metastasis, angiogenesis, apoptosis resistance, drug and immunosuppression, may also be an independent prognostic biomarker for variety cancers.This review broadly summarizes mechanisms regulate expression downstream oncogenic molecules after OPN binds to integrin receptors or CD44 receptors, which involve complex intracellular "signaling traffic network" (including key kinases, signaling pathways, transcription factors).In addition, we value OPN, synergistic female breast, non-small cell lung, prostate, colorectal, gastric, hepatocellular carcinomas.The tissues blood vary due differences study subjects detection methods, this aspect requires further systematization view applying clinical applications.Importantly, based on fact effect correlates above-mentioned molecules, work provide some help combination therapy targeting molecules.
Язык: Английский
Процитировано
14
Genes & Diseases, Год журнала: 2023, Номер 11(2), С. 701 - 710
Опубликована: Апрель 11, 2023
B-cell CLL/lymphoma 9 (BCL9) is considered a key developmental regulator and well-established oncogenic driver in multiple cancer types, mainly through potentiating the Wnt/β-catenin signaling. However, increasing evidences indicate that BCL9 also plays Wnt-independent roles. Herein, we summarized updates of canonical non-canonical functions cellular, physiological, or pathological processes. Moreover, concluded targeted inhibitors disrupt interaction β-catenin with reported recently.
Язык: Английский
Процитировано
8
Nutrition and Cancer, Год журнала: 2023, Номер 75(8), С. 1658 - 1672
Опубликована: Июнь 15, 2023
Baroni is an edible plant with anti-inflammatory, antidepressant, and anticancer activities. However, studies on
Язык: Английский
Процитировано
8
Chemosphere, Год журнала: 2024, Номер 352, С. 141375 - 141375
Опубликована: Фев. 5, 2024
Язык: Английский
Процитировано
3
Disease Markers, Год журнала: 2021, Номер 2021, С. 1 - 12
Опубликована: Авг. 6, 2021
Objective. To explore the expression, functions, and possible mechanisms of cysteine-rich intestinal protein 1 (CRIP1) in epithelial ovarian cancer. Methods. Using open microarray datasets from The Cancer Genome Atlas (TCGA), we identified tumorigenic genes Then, detected CRIP1 expression 26 pairs cancer tissue samples by immunohistochemistry (IHC) performed a correlation analysis between clinicopathological features. In addition, cell lines A2780 OVCAR3 were used to examine western blot qRT-PCR. Various function experiments related tumorigenesis including CCK8 assay, EdU, Annexin V-FITC/PI apoptosis wound healing, Transwell assay. epithelial-mesenchymal transition (EMT) markers was illustrate relationship EMT. Furthermore, KEGG pathway enrichment conducted reveal signaling pathways which is involved pathogenesis. Results. as an oncogene TCGA database. IHC score demonstrated that expressed at higher level tumours than tumour-adjacent tissues associated with pathological stage, grade, positive lymphatic metastasis. models, overexpressed serous Cell showed knockdown did not significantly affect proliferation or but could exert inhibitory effect on migration invasion, also induce changes EMT markers. metastasis through activation Wnt/β-catenin pathway. Conclusion. This study first demonstrate acts may promote tumour regulating EMT-related pathway, suggesting be important biomarker for progression.
Язык: Английский
Процитировано
16
Cancers, Год журнала: 2023, Номер 15(2), С. 551 - 551
Опубликована: Янв. 16, 2023
The p21 Activated Kinases (PAKs) are serine threonine kinases and play important roles in many biological processes, including cell growth, survival, cytoskeletal organization, migration, morphology. Recently, PAKs have emerged the process of liver disorders, cancer, hepatic ischemia-reperfusion injury, hepatitis, fibrosis, owing to their effects multiple signaling pathways various types. Activation promotes cancer growth metastasis contributes resistance radiotherapy chemotherapy, leading poor survival patients. also development progression hepatitis other pathological processes such as fibrosis injury. In this review, we summarized currently available studies about role disorders mechanisms involved, further explored potential therapeutic application PAK inhibitors with aim provide a comprehensive overview on current progress perspectives disorders.
Язык: Английский
Процитировано
6