Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 17, 2024
Despite
the
advanced
technologies
and
global
attention
on
cancer
treatment
strategies,
continues
to
claim
lives
adversely
affects
socio-economic
development.
Although
combination
therapies
were
anticipated
eradicate
this
disease,
resilient
restorative
nature
of
cancers
allows
them
proliferate
at
expense
host
immune
cells
energetically.
This
proliferation
is
driven
by
metabolic
profiles
specific
type
patient.
An
emerging
field
exploring
reprogramming
(MR)
predict
effective
treatments.
mini-review
discusses
recent
advancements
in
MR
that
have
contributed
predictive,
preventive,
precision
medicine.
Current
perspectives
mechanisms
various
types
prospects
for
personalized
medicine
are
essential
optimizing
outputs
necessary
International Journal of General Medicine,
Год журнала:
2023,
Номер
Volume 16, С. 1713 - 1733
Опубликована: Май 1, 2023
Non-small
cell
lung
cancer
(NSCLC)
is
currently
a
problem
in
the
clinic
and
society.
Tumor-related
macrophages
(TAMs)
tumor
microenvironment
(TME)
play
vital
role
development
of
NSCLC.Bioinformatics
was
used
to
analyze
Indoleamine
2,3-dioxygenase
1
(IDO1)
NSCLC
correlation
its
expression
with
CD163
expression.
The
IDO1
measured
by
immunohistochemistry,
their
colocalization
assessed
immunofluorescence.
M2
macrophage
polarization
induced,
coculture
model
cells
established.Bioinformatics
analysis
showed
that
promoted
metastasis
differentiation
inhibited
DNA
repair.
Moreover,
positively
correlated
We
discovered
related
differentiation.
In
vitro,
we
increased
invasion,
proliferation,
cells.In
conclusion,
determined
can
regulate
TAMs
promote
progression
NSCLC,
which
provides
partial
theoretical
evidence
for
use
inhibitors
treatment
NSCLC.
Technology in Cancer Research & Treatment,
Год журнала:
2024,
Номер
23
Опубликована: Янв. 1, 2024
Background:
Solute
carrier
family
3
member
2
(SLC3A2)
is
highly
expressed
in
various
types
of
cancers,
including
bladder
cancer
(BLCA).
However,
the
role
and
mechanism
SLC3A2
onset
progression
BLCA
are
still
unclear.
Methods:
The
interfering
plasmid
for
was
constructed
transfected
into
cells.
Cell
proliferation,
invasion,
migration
abilities
were
assessed
to
evaluate
impact
silencing
on
cell
growth.
M1
M2
macrophage
polarization
markers
detected
polarization.
levels
reactive
oxygen
species
(ROS),
lipid
peroxidation,
Fe
2+
,
as
well
expression
ferroptosis-related
proteins,
measured
assess
occurrence
ferroptosis.
Ferroptosis
inhibitors
used
verify
mechanism.
Results:
experimental
results
showed
that
lines.
cells
reduced
after
with
SLC3A2.
Interference
led
increase
decreased
M0
macrophages
co-cultured
tumor
Additionally,
interference
increased
ROS,
downregulated
solute
7
member11
(SLC7A11)
glutathione
peroxidase
4
(GPX4),
while
upregulated
acyl-coA
synthetase
long
chain
(ACSL4)
transferrin
receptor
1
(TFR1)
proliferation
impeded
by
ferroptosis
inhibitors.
Conclusion:
inhibited
growth
tumor-associated
promoting
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 11, 2024
Gut
microbiota
(GM)
and
metabolic
alterations
play
pivotal
roles
in
lung
cancer
(LC)
development
host
genetic
variations
are
known
to
contribute
LC
susceptibility
by
modulating
the
GM.
However,
causal
links
among
GM,
metabolite,
genes,
remain
be
fully
delineated.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 17, 2024
Despite
the
advanced
technologies
and
global
attention
on
cancer
treatment
strategies,
continues
to
claim
lives
adversely
affects
socio-economic
development.
Although
combination
therapies
were
anticipated
eradicate
this
disease,
resilient
restorative
nature
of
cancers
allows
them
proliferate
at
expense
host
immune
cells
energetically.
This
proliferation
is
driven
by
metabolic
profiles
specific
type
patient.
An
emerging
field
exploring
reprogramming
(MR)
predict
effective
treatments.
mini-review
discusses
recent
advancements
in
MR
that
have
contributed
predictive,
preventive,
precision
medicine.
Current
perspectives
mechanisms
various
types
prospects
for
personalized
medicine
are
essential
optimizing
outputs
necessary
