Unraveling the peripheral nervous System's role in tumor: A Double-edged Sword
Cancer Letters,
Год журнала:
2025,
Номер
611, С. 217451 - 217451
Опубликована: Янв. 8, 2025
Язык: Английский
Adrenergic microenvironment driven by cancer‐associated Schwann cells contributes to chemoresistance in patients with lung cancer
Yusuke Otani,
Haruyoshi Katayama,
Yidan Zhu
и другие.
Cancer Science,
Год журнала:
2024,
Номер
115(7), С. 2333 - 2345
Опубликована: Апрель 27, 2024
Doublecortin
(DCX)-positive
neural
progenitor-like
cells
are
purported
components
of
the
cancer
microenvironment.
The
number
DCX-positive
in
tissues
reportedly
correlates
with
progression;
however,
little
is
known
about
mechanism
by
which
these
affect
progression.
Here
we
demonstrated
that
cells,
found
all
major
histological
subtypes
lung
cancer,
cancer-associated
Schwann
(CAS)
and
contribute
to
chemoresistance
establishing
an
adrenergic
Mechanistically,
activation
Hippo
transducer
YAP/TAZ
was
involved
acquisition
new
traits
CAS
DCX
positivity.
We
further
revealed
express
catecholamine-synthesizing
enzymes
synthesize
adrenaline,
potentiates
through
YAP/TAZ.
Our
findings
shed
light
on
CAS,
drive
formation
microenvironment
reciprocal
regulation
tissues.
Язык: Английский
Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity”
Cancer and Metastasis Reviews,
Год журнала:
2025,
Номер
44(1)
Опубликована: Янв. 20, 2025
Nerve
signaling
within
the
tumor
microenvironment
(TME)
plays
a
critical
role
in
initiation,
progression,
and
metastasis
of
solid
tumors.
Due
to
their
highly
responsive
behavior
activation
upon
injury
cancer
onset,
this
review
specifically
focuses
on
how
sympathetic
nerves
rewire
TME.
Within
tumors,
closely
interact
with
various
TME
components,
combined
often
shifts
tumor-intrinsic
physiology
toward
tumor-supportive
phenotypes.
In
turn,
such
as
myeloid
cells,
lymphoid
extracellular
matrix
(ECM),
endothelial
associated
fibroblasts
(CAFs),
Schwann
secrete
neurotrophic
axon
guidance
factors
that
influence
both
outgrowth
cell
behavior,
further
exacerbating
progression
metastasis.
Here,
we
current
evidence
multidirectional
impacts
immune
non-immune
nature
these
communication
processes,
exploring
interactions
may
inform
future
therapeutics
impair
Язык: Английский
Changes in Adrenoceptor Expression Level Contribute to the Cellular Plasticity of Glioblastoma Cells
The Journal of Physiological Sciences,
Год журнала:
2025,
Номер
unknown, С. 100016 - 100016
Опубликована: Март 1, 2025
Glioblastoma
cells
are
known
to
regulate
their
cellular
plasticity
in
response
surrounding
microenvironment,
but
it
is
not
fully
understood
what
factors
contribute
the
cells'
changing
plasticity.
Here,
we
found
that
glioblastoma
alter
expression
level
of
adrenoreceptors
depending
on
differentiation
stage.
Catecholamines
abundant
central
nervous
system,
and
noradrenaline,
particular,
enhances
stemness
promotes
dedifferentiation
potential
already
differentiated
cells.
Antagonist
RNAi
experiments
revealed
signaling
through
α1D-adrenoreceptor
important
for
noradrenaline
action
We
also
high
was
associated
with
poor
prognosis
patients
gliomas.
These
data
suggest
increase
own
tumor
microenvironment
favorably
survival.
believe
our
findings
will
development
new
therapeutic
strategies
glioblastoma.
Язык: Английский
Intersection between lung cancer and neuroscience: opportunities and challenges
Cancer Letters,
Год журнала:
2025,
Номер
unknown, С. 217701 - 217701
Опубликована: Апрель 1, 2025
Язык: Английский
Tumor-associated Schwann cells as new therapeutic target in non-neurological cancers
Cancer Letters,
Год журнала:
2025,
Номер
unknown, С. 217748 - 217748
Опубликована: Апрель 1, 2025
Язык: Английский
Interplay Between Schwann Cells and Peripheral Cancers: Mechanisms and Therapeutic Targets in Cancer Progression
Glia,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 10, 2025
ABSTRACT
Cancer,
a
leading
global
health
concern,
is
characterized
by
uncontrolled
proliferation
of
cells,
high
invasion
into
surrounding
tissues,
and
eventual
metastasis
to
distant
organs.
The
complexity
cancer
further
amplified
diverse
cellular
components
within
the
tumor
microenvironment
(TME),
encompassing
both
cancerous
non‐cancerous
cells
that
fuel
tumorigenesis
progression.
Schwann
(SCs),
main
glial
peripheral
nervous
system,
have
emerged
as
crucial
TME
in
development.
Here,
we
summarize
multifaceted
roles
SCs
growth,
epithelial‐mesenchymal
transition,
perineural
invasion,
chemotherapy
resistance.
This
review
focuses
on
effects
eight
distinct
types,
particularly
pancreatic,
lung,
colorectal
cancers,
along
with
cancer‐related
pain,
one
most
common
symptoms
affect
quality
life
prognosis
patients.
Furthermore,
emphasize
therapeutic
potential
delving
advanced
technologies
clinical
strategies
related
SCs,
which
make
us
advocate
for
research
elucidate
events
molecular
mechanisms
underlying
SC‐cancer
relationship.
Translating
these
insights
applications
may
offer
new
hope
improved
management
patient
outcomes.
Язык: Английский
The Role of C1orf50 in Breast Cancer Progression and Prognosis
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 9, 2024
Abstract
Although
the
prognosis
of
breast
cancer
has
significantly
improved
compared
to
other
types
cancer,
there
are
still
some
patients
who
expire
due
recurrence
or
metastasis.
Therefore,
it
is
necessary
develop
a
method
identify
with
poor
at
early
stages
cancer.
In
process
discovering
new
prognostic
markers
from
genes
unknown
function,
we
found
that
expression
C1orf50
determines
patients,
especially
for
those
Luminal
A
This
study
aims
elucidate
molecular
role
in
progression.
Bioinformatic
analyses
dataset
TCGA,
and
vitro
analyses,
reveal
pathways
influenced
by
expression.
knockdown
suppressed
cell
cycle
cells
weakened
their
ability
maintain
undifferentiated
state
self-renewal
capacity.
Interestingly,
upregulation
increased
sensitivity
CDK4/6
inhibition.
addition,
was
be
more
abundant
than
normal
epithelium,
suggesting
involvement
pathogenesis.
Furthermore,
mRNA
level
positively
correlated
PD-L1
its
related
factors.
These
results
suggest
promotes
progression
through
upregulation,
maintenance
stemness
immune
evasion
mechanisms.
Our
uncovers
biological
functions
progression,
finding
not
previously
reported
any
type
Язык: Английский
What a wonderful world!
Genes & Development,
Год журнала:
2024,
Номер
38(17-20), С. 802 - 804
Опубликована: Сен. 1, 2024
The
world
of
cancer
science
is
moving
toward
a
paradigm
shift
in
making
connections
with
neuroscience.
After
decades
research
on
genetic
instability
and
mutations
or
the
tumor
microenvironment,
emerging
evidence
suggests
that
malignant
able
to
hijack
use
brain
its
network
peripheral
central
neurons
as
disrupters
homeostasis
body.
Whole-body
requires
brain-body
circuits
maintain
survival
health
via
processes
interoception,
immunoception,
nociception.
It
now
likely
disturbs
physiological
communication
bidirectional
connections.
Язык: Английский
The role of C1orf50 in breast cancer progression and prognosis
Breast Cancer,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
Abstract
Although
the
prognosis
of
breast
cancer
has
significantly
improved
compared
to
other
types
cancer,
there
are
still
some
patients
who
expire
due
recurrence
or
metastasis.
Therefore,
it
is
necessary
develop
a
method
identify
with
poor
at
early
stages
cancer.
In
process
discovering
new
prognostic
markers
from
genes
unknown
function,
we
found
that
expression
C1orf50
determines
patients,
especially
for
those
Luminal
A
This
study
aims
elucidate
molecular
role
in
progression.
Bioinformatic
analyses
dataset
TCGA,
and
vitro
analyses,
reveal
pathways
influenced
by
expression.
knockdown
suppressed
cell
cycle
cells
weakened
their
ability
maintain
undifferentiated
state
self-renewal
capacity.
Interestingly,
upregulation
increased
sensitivity
CDK4/6
inhibition.
addition,
was
be
more
abundant
than
normal
epithelium,
suggesting
C1orf50’s
involvement
pathogenesis.
Furthermore,
mRNA
level
positively
correlated
PD-L1
its
related
factors.
These
results
suggest
promotes
progression
through
upregulation,
maintenance
stemness,
immune
evasion
mechanisms.
Our
uncovers
biological
functions
progression,
finding
not
previously
reported
any
type
Язык: Английский