SNHG15‐mediated feedback loop interplays with HNRNPA1/SLC7A11/GPX4 pathway to promote gastric cancer progression

Cancer Science, Год журнала: 2024, Номер 115(7), С. 2269 - 2285

Опубликована: Май 8, 2024

Dysregulation of long noncoding RNA (lncRNA) expression plays a pivotal role in the initiation and progression gastric cancer (GC). However, regulation lncRNA SNHG15 GC has not been well studied. Mechanisms for ferroptosis by have revealed. Here, we aimed to explore SNHG15-mediated biological functions underlying molecular mechanisms GC. The novel was identified analyzing RNA-sequencing (RNA-seq) data tissues from our cohort TCGA dataset, further validated qRT-PCR cells tissues. Gain- loss-of-function assays were performed examine on both vitro vivo. highly expressed enhanced positively correlated with malignant stage poor prognosis patients. studies showed that required affect cell growth, migration invasion Mechanistically, oncogenic transcription factors E2F1 MYC could bind promoter enhance its expression. Meanwhile, increased mRNA sponging miR-24-3p. Notably, also stability SLC7A11 cytoplasm competitively binding HNRNPA1. In addition, inhibited through an HNRNPA1-dependent SLC7A11/GPX4 axis. Our results support model which E2F1- MYC-activated regulates via modulation axis, serves as critical effectors progression, provides new therapeutic direction treatment

Язык: Английский

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A novel defined risk signature of ferroptosis-related lncRNAs for predicting prognosis, immune infiltration, and chemotherapy response in multiple myeloma

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 11, 2025

Язык: Английский

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Research Progress of LncRNA and Lipid Metabolism in Colorectal Cancer

Bioprocess, Год журнала: 2025, Номер 15(01), С. 86 - 91

Опубликована: Янв. 1, 2025

Язык: Английский

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Key genes and processes affected by atorvastatin treatment in mouse diaphragm muscle

Archives of Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

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Current concepts of the crosstalk between lncRNA and E2F1: shedding light on the cancer therapy

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Июль 25, 2024

Long noncoding RNAs (lncRNAs) constitute a distinctive subset of RNA molecules with limited protein-coding potential, which exert crucial impacts on various biological activities. In the context cancer, dysregulated lncRNAs function as essential regulators that affect tumor initiation and malignant progression. These serve competitive endogenous (ceRNAs) through sponging microRNAs regulating expression targeted genes. Moreover, they also directly bind to RNA-binding proteins, can be integrated into complex mechanistic network. E2F1, an extensively studied transcription factor, mediates multiple behaviors by cell cycle progression, metastasis, therapeutic response. Emerging evidence suggests play pivotal role in E2F1 pathway. This review aims elucidate intricate gene regulatory programs between cancer We elaborate distinct networks involved emphasizing potential lncRNAs/E2F1 axes promising targets for therapy. Additionally, we provide novel perspectives current evidence, limitations, future directions targeting human cancers. Fully deciphering network lncRNA/E2F1-mediated mechanisms could facilitate translation findings clinical course, such efforts ultimately significantly improve prognosis patients.

Язык: Английский

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TRIB3 knockdown increases the sensitivity of clear cell renal cell carcinoma to sunitinib by inducing ferroptosis

Cellular Signalling, Год журнала: 2024, Номер 124, С. 111421 - 111421

Опубликована: Сен. 17, 2024

Язык: Английский

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Advances in understanding the role of lncRNA in ferroptosis

PeerJ, Год журнала: 2024, Номер 12, С. e17933 - e17933

Опубликована: Авг. 26, 2024

LncRNA is a type of transcript with length exceeding 200 nucleotides, which was once considered junk no biological function during the transcription process. In recent years, lncRNA has been shown to act as an important regulatory factor at multiple levels gene expression, affecting various programmed cell death modes including ferroptosis. Ferroptosis, new form death, characterized by deficiency cysteine or inactivation glutathione peroxidase, leading depletion glutathione, aggregation iron ions, and lipid peroxidation. These processes are influenced many physiological processes, such Nrf2 pathway, autophagy, p53 pathway so on. An increasing number studies have that can block expression specific molecules through decoy effect, guide proteins function, promote interactions between scaffolds. action regulate key factors in metabolism, antioxidant metabolism epigenetic genetic regulation, thereby regulating process this review, we snapshotted mechanism ferroptosis example, emphasizing regulation on these pathways, helping fully understand evolution fate.

Язык: Английский

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Alleviates Effects of γ-cyclodextrin/Genistein Inclusion Complex on Oxidative Stress Injury Induced by Organic Hydrogen Peroxide in PC12 Cells via Nrf2/GPx4 Signaling Pathway

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105631 - 105631

Опубликована: Дек. 1, 2024

Язык: Английский

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LncRNA SSTR5-AS1 promotes esophageal carcinoma through regulating ITGB6/JAK1/STAT3 signaling

Epigenomics, Год журнала: 2024, Номер 16(17), С. 1133 - 1148

Опубликована: Сен. 1, 2024

To investigate function of somatostatin receptor 5 antisense RNA 1 (SSTR5-AS1) in esophageal carcinoma (ESCA).

Язык: Английский

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SOD2 promotes gastric tumorigenesis mediated by Helicobacter pylori and enhances resistance to 5-fluorouracil in gastric cancer

iScience, Год журнала: 2024, Номер 28(2), С. 111553 - 111553

Опубликована: Дек. 7, 2024

Язык: Английский

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