Cutibacterium acnes‐derived extracellular vesicles promote tumor growth in renal cell carcinoma
Cancer Science,
Год журнала:
2024,
Номер
115(8), С. 2578 - 2587
Опубликована: Апрель 29, 2024
Bacterial
flora
are
present
in
various
parts
of
the
human
body,
including
intestine,
and
thought
to
be
involved
etiology
diseases
such
as
multiple
sclerosis,
intestinal
diseases,
cancer,
uterine
diseases.
In
recent
years,
presence
bacterial
16S
rRNA
genes
has
been
revealed
blood,
which
was
previously
a
sterile
environment,
characteristic
blood
microbiomes
have
detected
However,
mechanism
origin
information
unknown.
this
study,
we
performed
metagenomic
analysis
DNA
serum
extracellular
vesicles
from
five
healthy
donors
seven
patients
with
renal
cell
carcinoma
Cutibacterium
acnes
carcinoma.
addition,
C.
significantly
reduced
postoperative
compared
that
preoperative
these
also
tumor
tissue
tissue-associated
microbiota,
suggesting
an
association
between
were
taken
up
by
cells
enhance
their
proliferative
potential.
exhibited
tumor-promoting
activity
mouse
model
cancer
allografts
enhanced
angiogenesis.
These
results
suggest
released
localized
tissues
act
manner.
Язык: Английский
Interactions Between Radiotherapy Resistance Mechanisms and the Tumor Microenvironment
Critical Reviews in Oncology/Hematology,
Год журнала:
2025,
Номер
unknown, С. 104705 - 104705
Опубликована: Март 1, 2025
Язык: Английский
Dysbiosis in Human Urinary Microbiota May Differentiate Patients with a Bladder Cancer
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 10159 - 10159
Опубликована: Сен. 21, 2024
Recent
interest
in
noninvasive
diagnostic
approaches
has
highlighted
the
potential
of
urinary
microbiota
as
a
novel
biomarker
for
bladder
cancer.
This
study
investigated
30
cancer
patients
and
32
healthy
controls
using
specific
NGS
protocol
that
sequences
eight
hypervariable
regions
16S
rRNA
gene,
providing
detailed
insights
into
composition.
The
relative
abundance
microbial
compositions
urine
samples
from
was
analyzed
across
various
taxonomic
levels.
No
notable
differences
were
at
phylum,
class,
order,
family
At
genus
level,
53%
detected
genera
represented
either
or
controls.
Microbial
diversity
significantly
lower
patients.
differential
analysis
identified
five
genera,
Rhodanobacter,
Cutibacterium,
Alloscardovia,
Moryella,
Anaeroglobus,
more
abundant
Notably,
Rhodanobacter
present
20
but
absent
Conversely,
40
including
Lactobacillus,
Propionibacterium,
Bifidobacterium,
exhibited
reduced
These
findings
suggest
some
may
serve
biomarkers
cancer,
highlighting
need
further
research
to
explore
their
roles
disease
pathogenesis
applications
diagnostics
therapeutics.
Язык: Английский
Different Prostatic Tissue Microbiomes between High- and Low-Grade Prostate Cancer Pathogenesis
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8943 - 8943
Опубликована: Авг. 16, 2024
Numerous
human
pathologies,
such
as
neoplasia,
are
related
to
particular
bacteria
and
changes
in
microbiome
constituents.
To
investigate
the
association
between
an
imbalance
of
prostate
carcinoma,
gene
functionality
from
tissues
patients
with
high-grade
tumor
(HGT)
low-grade
(LGT)
were
compared
utilizing
next-generation
sequencing
(NGS)
technology.
The
results
showed
abnormalities
bacterial
profiles
HGT
LGT
specimens,
indicating
alterations
make-up
populations
functionalities.
specimens
higher
frequencies
Cutibacterium,
Pelomonas,
Corynebacterium
genera
than
specimens.
Cell
proliferation
cytokine
assays
also
a
significant
cancer
cells
elevated
levels
treated
respectively,
supporting
earlier
findings.
In
summary,
differences
populations,
suggesting
that
different
might
characterize
malignancies.
Язык: Английский
Microbiota and urinary tumor immunity: Mechanisms, therapeutic implications, and future perspectives
Chinese Journal of Cancer Research,
Год журнала:
2024,
Номер
36(6), С. 596 - 615
Опубликована: Янв. 1, 2024
Язык: Английский
Liquid biopsy for renal cell carcinoma
Clinica Chimica Acta,
Год журнала:
2024,
Номер
565, С. 119964 - 119964
Опубликована: Сен. 10, 2024
Язык: Английский
Bacterial information in serum extracellular vesicles reflects the inflammation of adherent perinephric fat
Cancer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 20, 2024
Abstract
Adipose
tissue
and
bacterial
flora
are
involved
in
metabolism
the
human
body.
However,
relationship
between
two
remains
unclear.
Recently,
presence
of
circulating
DNAs
has
been
reported.
We
previously
reported
utility
DNA
serum
extracellular
vesicles
(EVs)
for
diagnosing
patients
with
renal
cell
carcinoma
(RCC).
In
this
study,
we
aimed
to
assess
whether
there
is
a
correlation
EVs
inflammation
adipose
tissue.
undertook
16S
rRNA
metagenomic
analysis
from
77
RCC
(the
derivation
cohort).
discovered
that
Enterobacteriaceae,
Polaromonas,
Coxiellaceae
were
highly
expressed
low
Mayo
adhesive
probability
(MAP)
scores.
A
lower
MAP
score
reflects
reduced
risk
dense
adhesions.
Additionally,
combined
these
create
EPC
(Enterobacteriaceae,
Coxiellaceae)
index
predicts
0.
Subsequently,
32
validation
The
could
distinguish
scores
those
high
(area
under
curve
[AUC],
0.76;
sensitivity,
56%;
specificity,
85%)
(AUC,
0.81;
100%;
62%)
cohorts.
These
results
suggest
reflect
adherent
perinephric
fat
around
kidney.
Язык: Английский