LUCAT1-Mediated Competing Endogenous RNA (ceRNA) Network in Triple-Negative Breast Cancer DOI Creative Commons
Deepak Verma, Sumit Siddharth, Ashutosh S. Yende

и другие.

Cells, Год журнала: 2024, Номер 13(22), С. 1918 - 1918

Опубликована: Ноя. 19, 2024

Breast cancer is a heterogeneous disease comprising multiple molecularly distinct subtypes with varied prevalence, prognostics, and treatment strategies. Among them, triple-negative breast cancer, though the least prevalent, most aggressive subtype, limited therapeutic options. Recent emergence of competing endogenous RNA (ceRNA) networks has highlighted how long noncoding RNAs (lncRNAs), microRNAs (miRs), mRNA orchestrate complex interplay meticulously modulating functionality. Focusing on TNBC, this study aimed to construct ceRNA network using differentially expressed lncRNAs, miRs, mRNAs. We queried lncRNAs (DElncRNAs) between TNBC luminal samples found 389 upregulated 386 downregulated including novel transcripts in TNBC. DElncRNAs were further evaluated for their clinical, functional, mechanistic relevance TNBCs lnc2cancer 3.0 database, which presented LUCAT1 (lung cancer-associated transcript 1) as putative node. Next, (lncRNA-miRNA-mRNA) was established. Several miRNA-mRNA connections implicated regulating stemness (LUCAT1-miR-375-Yap1, LUCAT1-miR181-5p-Wnt, LUCAT1-miR-199a-5p-ZEB1), apoptosis (LUCAT1-miR-181c-5p-Bcl2), drug efflux (LUCAT1-miR-200c-ABCB1, LRP1, MRP5, MDR1), sheddase activities (LUCAT1-miR-493-5p-ADAM10) identified, indicating an intricate regulatory mechanism Indeed, silencing led mitigated cell growth, migration, stem-like features This work sheds light implies its involvement growth progression.

Язык: Английский

Recent Exploration of Solid Cancer Biomarkers Hidden Within Urine or Blood Exosomes That Provide Fundamental Information for Future Cancer Diagnostics DOI Creative Commons

Tomoaki Hara,

Sikun Meng, Aya Hasan Alshammari

и другие.

Diagnostics, Год журнала: 2025, Номер 15(5), С. 628 - 628

Опубликована: Март 5, 2025

Cancer cells exhibit abnormal behavior compared to normal cells. They ignore growth arrest signals such as contact inhibition, a mechanism that stops their proliferation when they collide with surrounding cells, and proliferate in an uncontrolled manner, destroying tissue. Early detection treatment of cancer are therefore important for healthy longevity. differ from characteristic gene expression due abnormalities. markers reflect these characteristics have been searched applied diagnosis. Although analysis blood antigens has the main method, further development diagnostic system is needed early cancer. Next-generation sequencers improved technology, making it possible analyze detailed nucleic acid molecules or urine. In addition, release extracellular vesicles, exosomes, which known contain may serve markers. This review summarizes latest findings on exosomal

Язык: Английский

Процитировано

0
LUCAT1-Mediated Competing Endogenous RNA (ceRNA) Network in Triple-Negative Breast Cancer DOI Creative Commons
Deepak Verma, Sumit Siddharth, Ashutosh S. Yende

и другие.

Cells, Год журнала: 2024, Номер 13(22), С. 1918 - 1918

Опубликована: Ноя. 19, 2024

Breast cancer is a heterogeneous disease comprising multiple molecularly distinct subtypes with varied prevalence, prognostics, and treatment strategies. Among them, triple-negative breast cancer, though the least prevalent, most aggressive subtype, limited therapeutic options. Recent emergence of competing endogenous RNA (ceRNA) networks has highlighted how long noncoding RNAs (lncRNAs), microRNAs (miRs), mRNA orchestrate complex interplay meticulously modulating functionality. Focusing on TNBC, this study aimed to construct ceRNA network using differentially expressed lncRNAs, miRs, mRNAs. We queried lncRNAs (DElncRNAs) between TNBC luminal samples found 389 upregulated 386 downregulated including novel transcripts in TNBC. DElncRNAs were further evaluated for their clinical, functional, mechanistic relevance TNBCs lnc2cancer 3.0 database, which presented LUCAT1 (lung cancer-associated transcript 1) as putative node. Next, (lncRNA-miRNA-mRNA) was established. Several miRNA-mRNA connections implicated regulating stemness (LUCAT1-miR-375-Yap1, LUCAT1-miR181-5p-Wnt, LUCAT1-miR-199a-5p-ZEB1), apoptosis (LUCAT1-miR-181c-5p-Bcl2), drug efflux (LUCAT1-miR-200c-ABCB1, LRP1, MRP5, MDR1), sheddase activities (LUCAT1-miR-493-5p-ADAM10) identified, indicating an intricate regulatory mechanism Indeed, silencing led mitigated cell growth, migration, stem-like features This work sheds light implies its involvement growth progression.

Язык: Английский

Процитировано

1