Design, synthesis, biological evaluation, and in silico studies of novel N-substituted-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carboxamides as promising anticancer agents DOI Creative Commons

Navid Dastyafteh,

Manica Negahdaripour, Mohammad Hosein Sayahi

и другие.

RSC Advances, Год журнала: 2024, Номер 14(48), С. 35323 - 35335

Опубликована: Янв. 1, 2024

Synthesis and cytotoxicity evaluation of novel benzimidazoles were explained. The most potent derivative was subjected to cell cycle, apoptosis, in silico investigations. Compound 5o proved be a promising anticancer agent.

Язык: Английский

Synthesis, crystal structures and anticancer studies of Ni (Ⅱ) and Co (III) complexes based on 2-(2-aminophenyl)-1H-benzimidazole Schiff base derivatives DOI

Hou Cong Li,

Y. Zheng, Ming Wang

и другие.

Inorganica Chimica Acta, Год журнала: 2024, Номер unknown, С. 122506 - 122506

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1
Syntheses and Cytotoxicities of Quinazolinone-Based Conjugates DOI Open Access

Hieu Trong Le,

Kiep Minh,

Quy Phu Nguyen

и другие.

Chemical and Pharmaceutical Bulletin, Год журнала: 2024, Номер 72(1), С. 61 - 67

Опубликована: Янв. 11, 2024

Two novel series of quinazolinone-based hybrids, including quinazolinone-1,3,4-oxadiazoles (10a–l) and quinazolinone-1,3,4-oxadiazole-benzimidazoles (8a–e), were designed synthesized their cytotoxic activities against three human cancer cell lines, lung (A549), cervical (HeLa), breast (MCF-7), evaluated. The assays revealed that 10i with a lipophilic 4-fluoro-phenyl moiety at the C-2 position quinazolinone ring displayed good cytotoxicities A549 MCF-7 while 8b–d thioether-linked benzimidazole incorporated on right side oxadiazole induced comparable stronger toward line, relative to simple two-heterocycle-containing hybrid 10i. These hybrids could be considered as lead compounds merit further optimization development anti-cancer agents.

Язык: Английский

Процитировано

0
Deciphering the Cytotoxic and Antioxidant Potential of 3,5-Disubstituted Isoxazole-linked Benzimidazolone Derivatives DOI
Mohamed Adardour, Soufiane Drioua,

Marouane Ait Lahcen

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер 1320, С. 139683 - 139683

Опубликована: Авг. 17, 2024

Язык: Английский

Процитировано

0
Sustainable and Advanced LED-Implanted Microfluidic Photoreactor with Coupled Optical Fiber Enabling Efficient Photocatalytic Synthesis Beside Online Reaction Progress Monitoring DOI Creative Commons

Gyanendra Chaudhary,

Amar Dhwaj,

Aman Verma

и другие.

ACS Omega, Год журнала: 2024, Номер 9(41), С. 42267 - 42277

Опубликована: Окт. 4, 2024

The conventional methods for the photoinduced synthesis of benzimidazoles may need further improvement regarding a safer and energy-efficient platform with in-process monitoring maximum yield within much reduced reaction time. This work describes use novel optofluidic Lab-on-a-Chip technology safer, energy-efficient, expedited benzimidazole derivatives in excellent yields along real-time quantitative measurement during product formation. innovative method involves LED-embedded microfluidic reactors, allowing rapid via condensation cyclization reactions aryl aldehydes

Язык: Английский

Процитировано

0
Design, synthesis, biological evaluation, and in silico studies of novel N-substituted-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazole-6-carboxamides as promising anticancer agents DOI Creative Commons

Navid Dastyafteh,

Manica Negahdaripour, Mohammad Hosein Sayahi

и другие.

RSC Advances, Год журнала: 2024, Номер 14(48), С. 35323 - 35335

Опубликована: Янв. 1, 2024

Synthesis and cytotoxicity evaluation of novel benzimidazoles were explained. The most potent derivative was subjected to cell cycle, apoptosis, in silico investigations. Compound 5o proved be a promising anticancer agent.

Язык: Английский

Процитировано

0