
ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
This study focused on the design, synthesis, chemical characterization, and potential inhibitory of thiazole-methylsulfonyl derivatives against carbonic anhydrase enzymes. The synthesized compounds, with characteristics both thiazole ring methyl sulfonyl group, were through a two-step scheme, their structures confirmed NMR spectroscopy HRMS. Additionally, structure compound 2b was elucidated by an X-ray study. An enzyme inhibition assay performed to assess biological activity anhydrases, compounds showed promising results anhydrases I II, highlighting for specificity targeted therapy. effects these molecules in vitro activities investigated spectrophotometric methods. For this purpose, concentrations (IC50 values) that inhibited isoenzymes (hCA hCA II) 50% calculated. IC50 values found between 39.38-198.04 μM (AAZ = 18.11 μM) 39.16-86.64 20.65 μM). Molecular docking studies have shown 2a 2h exhibit stable interaction networks combinations studies, molecular thus enlighten significance further optimization pharmacological profiling developing therapeutic agents anhydrase. Moreover, provides insight future research synthesis heterocyclic applications.
Язык: Английский