Journal of Multidisciplinary Sciences,
Год журнала:
2023,
Номер
5(1), С. 37 - 49
Опубликована: Июнь 30, 2023
In
women
of
childbearing
age,
polycystic
ovarian
syndrome
(PCOS)
is
the
most
common
endocrine
and
metabolic
condition.
Ovulatory
dysfunction,
clinical
symptoms
hyperandrogenism,
multiple
cystic
ovaries
are
hallmarks
PCOS.
Women
who
have
PCOS
may
irregular
insulin
activity
in
addition
to
other
difficulties
such
as
pattern
hair
loss,
acne,
obesity,
infertility,
hirsutism.
An
unhealthy
lifestyle,
hereditary
causes,
androgen
exposures,
neuroendocrine
factors
frequently
causes
This
results
an
unbalanced
hormonal
state,
high
insulin,
inflammation.
Due
overlapping
issues,
patients'
cancer
risk
has
been
subject
debate
for
decades.This
review
article
examines
relationship
between
various
types
reproductive
cancers,
focusing
on
possible
reasons
patients.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Май 16, 2024
Introduction
Polycystic
ovary
syndrome
(PCOS)
is
often
associated
with
metabolic-associated
fatty
liver
disease
(MAFLD).
MAFLD
has
been
altered
hepatic
function,
systemic
dysmetabolism,
and
abnormal
circulating
levels
of
signaling
molecules
called
organokines.
Here,
we
assessed
the
effects
two
randomized
treatments
on
a
set
organokines
in
adolescent
girls
PCOS
without
obesity,
report
associations
biomarkers
damage,
which
were
longitudinally
aforementioned
studies
as
safety
markers.
Materials
methods
Liver
enzymes
[aspartate
aminotransferase
(AST),
alanine
(ALT),
gamma-glutamyl
transferase
(GGT)]
markers
previous
pilot
comparing
an
oral
contraceptive
(OC)
those
low-dose
combination
spironolactone-pioglitazone-metformin
(spiomet)
for
1
year.
As
post
hoc
endpoint,
fibroblast
growth
factor-21
(FGF21),
diazepam-binding
protein-1
(DBI),
meteorin-like
protein
(METRNL)
by
ELISA
after
6
months
OC
(N
=
26)
or
spiomet
28).
Auxological,
endocrine-metabolic,
body
composition
(using
DXA),
abdominal
fat
partitioning
MRI)
also
evaluated.
Healthy,
age-matched
17)
served
controls.
Results
Circulating
ALT
GGT
increased
during
treatment
returned
to
baseline
concentrations
post-treatment
phase;
contrast,
elicited
no
detectable
changes
concentrations.
In
relation
treatment,
(1)
FGF21
significantly
higher
adolescents
than
control
girls;
(2)
DBI
lower
OC-treated
controls
spiomet-treated
(3)
differences
observed
METRNL
between
Serum
directly
correlated
only
(R
0.449,
P
0.036
R
0.552,
0.004,
respectively).
Conclusion
The
on-treatment
increase
occurring
levels,
suggesting
enhanced
synthesis
reaction
treatment.
Clinical
Trial
Registration
https://doi.org
,
identifiers
10.1186/ISRCTN29234515,
10.1186/ISRCTN11062950.
Australian Prescriber,
Год журнала:
2024,
Номер
47(4), С. 109 - 112
Опубликована: Авг. 19, 2024
Polycystic
ovary
syndrome
is
a
common
and
frequently
undiagnosed
female
endocrine
disorder
that
associated
with
diverse
symptoms
features,
an
increased
risk
of
long-term
chronic
diseases
such
as
type
2
diabetes
cardiovascular
disease.
Pharmacotherapy
for
polycystic
should
be
directed
at
the
key
concerns
individual
patient.
The
combined
oral
contraceptive
pill
or
metformin
may
prescribed
irregular
periods.
preferred
over
antiandrogens
treatment
hirsutism
acne.
Metformin
benefit
reducing
excess
body
weight
improving
hormonal
metabolic
outcomes
in
those
high
(e.g.
mass
index
greater
than
25
kg/m
Polycystic
ovary
syndrome
(PCOS)
is
a
common
endocrinopathy
among
women
in
the
reproductive
age
group.
PCOS
defined
by
Rotterdam
criteria,
which
include
hyperandrogenism,
oligo-anovulation,
and
polycystic
ovaries
on
ultrasound.
The
symptoms
are
irregular
or
absent
periods,
acne,
hirsutism,
alopecia
androgenica.
Increased
prevalence
of
metabolic
seen
with
PCOS,
increases
cardiovascular
risk
(CVR).
Insulin
resistance
(IR),
being
most
often
patients
obesity.
IR
obesity
induce
chronic
low-grade
inflammation
increasing
various
inflammatory
markers.
Increase
parameters
tumor
necrosis
factor-alpha
(TNF-alpha),
interleukin-1
(IL-1),
interleukin-6
(IL-6),
C-
reactive
protein
(CRP),
plasminogen,
endothelin-1,
fibrinogen,
cystatin-C,
fetuin
B,
vascular
endothelial
growth
factor,
endostatin
levels
have
been
documented
PCOS-affected
women.
Microbiota
alteration
also
this
demographic,
metabolites
like
trimethylamine-N-oxide
(TMAO).
TMAO,
because
its
pro-atherosclerotic
activity,
linked
to
an
increase
CVR.
In
systematic
review,
we
intended
discover
causes
factors
that
lead
increased
CVR
diagnosed
PCOS.
This
review
used
PubMed,
regular
keywords,
Google
Scholar.
inclusion
criteria
included
human
female
population
all
ages
literature
available
English
language
free
full
text
published
between
years
2019
2024.
exclusion
research
involving
animals,
works
before
2019,
articles
written
other
than
English,
not
publicly
available.
A
total
89
were
identified,
8
final
selected
after
quality
assessment.
Journal of Obstetrics and Gynaecology Research,
Год журнала:
2024,
Номер
51(1)
Опубликована: Дек. 11, 2024
This
study
evaluates
the
clinical
effects
of
a
ketogenic
diet
(KD)
versus
traditional
comprehensive
intervention,
including
lifestyle
changes
and
oral
contraceptives,
in
overweight
or
obese
polycystic
ovary
syndrome
(PCOS)
patients.
Journal of Multidisciplinary Sciences,
Год журнала:
2023,
Номер
5(1), С. 37 - 49
Опубликована: Июнь 30, 2023
In
women
of
childbearing
age,
polycystic
ovarian
syndrome
(PCOS)
is
the
most
common
endocrine
and
metabolic
condition.Ovulatory
dysfunction,
clinical
symptoms
hyperandrogenism,
multiple
cystic
ovaries
are
hallmarks
PCOS.Women
who
have
PCOS
may
irregular
insulin
activity
in
addition
to
other
difficulties
such
as
pattern
hair
loss,
acne,
obesity,
infertility,
hirsutism.An
unhealthy
lifestyle,
hereditary
causes,
androgen
exposures,
neuroendocrine
factors
frequently
causes
PCOS.This
results
an
unbalanced
hormonal
state,
high
insulin,
inflammation.Due
overlapping
issues,
patients'
cancer
risk
has
been
subject
debate
for
decades.This
review
article
examines
relationship
between
various
types
reproductive
cancers,
focusing
on
possible
reasons
patients.
Journal of Multidisciplinary Sciences,
Год журнала:
2023,
Номер
5(1), С. 37 - 49
Опубликована: Июнь 30, 2023
In
women
of
childbearing
age,
polycystic
ovarian
syndrome
(PCOS)
is
the
most
common
endocrine
and
metabolic
condition.
Ovulatory
dysfunction,
clinical
symptoms
hyperandrogenism,
multiple
cystic
ovaries
are
hallmarks
PCOS.
Women
who
have
PCOS
may
irregular
insulin
activity
in
addition
to
other
difficulties
such
as
pattern
hair
loss,
acne,
obesity,
infertility,
hirsutism.
An
unhealthy
lifestyle,
hereditary
causes,
androgen
exposures,
neuroendocrine
factors
frequently
causes
This
results
an
unbalanced
hormonal
state,
high
insulin,
inflammation.
Due
overlapping
issues,
patients'
cancer
risk
has
been
subject
debate
for
decades.This
review
article
examines
relationship
between
various
types
reproductive
cancers,
focusing
on
possible
reasons
patients.
