Defective mitophagy in Alzheimer’s disease

Ageing Research Reviews, Год журнала: 2020, Номер 64, С. 101191 - 101191

Опубликована: Окт. 3, 2020

Язык: Английский

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The Role of Autophagy and Mitophagy in Bone Metabolic Disorders

International Journal of Biological Sciences, Год журнала: 2020, Номер 16(14), С. 2675 - 2691

Опубликована: Янв. 1, 2020

Bone metabolic disorders include osteolysis, osteoporosis, osteoarthritis and rheumatoid arthritis.Osteoblasts osteoclasts are two major types of cells in bone constituting homeostasis.The imbalance between formation by osteoblasts resorption has been shown to have a direct contribution the onset these diseases.Recent evidence indicates that autophagy mitophagy, selective mitochondria, may play vital role regulating proliferation, differentiation function osteoclasts.Several signaling pathways, including PINK1/Parkin, SIRT1, MAPK8/FOXO3, Beclin-1/BECN1, p62/SQSTM1, mTOR implied regulation mitophagy cells.Here we review current progress about disorders, as well molecular activated or deactivated during this process.Together, hope draw attention their potential new target for treatment diseases requirements further mechanism studies.

Язык: Английский

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Mitophagy pathways in health and disease

The Journal of Cell Biology, Год журнала: 2020, Номер 219(11)

Опубликована: Авг. 14, 2020

Mitophagy is an evolutionarily conserved process involving the autophagic targeting and clearance of mitochondria destined for removal. Recent insights into complex nature overlapping pathways regulating mitophagy illustrate mitophagy's essential role in maintaining health mitochondrial network. In this review, we highlight recent studies that have changed way understood, from initiation through lysosomal degradation. We outline numerous mitophagic receptors triggers, with a focus on basal physiologically relevant cues, offering insight why they lead to also explore how maintains homeostasis at organ system levels loss may play diverse group diseases, including cardiovascular, metabolic, neurodegenerative diseases. With disrupted affecting such wide array physiological processes, deeper understanding modulate could provide avenues therapies.

Язык: Английский

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Mitophagy in Human Diseases

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(8), С. 3903 - 3903

Опубликована: Апрель 9, 2021

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays an important role during development and fundamental in highly differentiated post-mitotic cells are dependent on aerobic metabolism, such as neurons, muscle cells, hepatocytes. Both defective excessive mitophagy have been proposed to contribute age-related neurodegenerative diseases, Parkinson’s Alzheimer’s metabolic vascular complications of diabetes, myocardial injury, dystrophy, liver disease, among others. Pharmacological or dietary interventions restore homeostasis facilitate the elimination irreversibly damaged mitochondria, thus, could serve potential therapies several chronic diseases. However, despite extraordinary advances this field, mainly derived from vitro preclinical animal models, human applications based regulation mitochondrial quality patients not yet approved. In review, we summarize key autophagy pathways their prevalent diseases highlight use specific interventions.

Язык: Английский

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Beyond autophagy: LC3-associated phagocytosis and endocytosis

Science Advances, Год журнала: 2022, Номер 8(43)

Опубликована: Окт. 26, 2022

Noncanonical functions of the autophagy machinery in pathways including LC3-associated phagocytosis and endocytosis have garnered increasing interest both normal physiology pathobiology. New discoveries over past decade noncanonical uses these distinct molecular mechanisms led to robust investigation into roles single-membrane LC3 lipidation. now been implicated regulation multiple processes ranging from debris clearance, cellular signaling, immune inflammation. Accumulating evidence is demonstrating a variety disease states host-pathogen responses, autoimmunity, cancer, neurological neurodegenerative pathologies. Here, we broadly summarize differences mechanistic between LAP LANDO highlight some key innate function, inflammation, pathology.

Язык: Английский

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Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(7), С. 3330 - 3330

Опубликована: Март 24, 2021

Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there no cure for it. Several pathologic alterations have been described in the brain of AD patients, but ultimate causative mechanisms are still elusive. The classic hallmarks AD, including amyloid plaques (Aβ) tau tangles (tau), most studied features AD. Unfortunately, all efforts targeting these pathologies failed to show desired efficacy patients so far. Neuroinflammation impaired autophagy two other main known It has reported that exist long before emergence any clinical manifestation Microglia inflammatory cells considered by many researchers as next hope finding viable therapeutic target Interestingly, it appears mitophagy also changed Inside cells, inflammation interact bidirectional manner. In current review, we briefly discussed an overview on then provided comprehensive discussion role pathways microglia their involvement pathogenesis.

Язык: Английский

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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Biogerontology, Год журнала: 2023, Номер 24(5), С. 609 - 662

Опубликована: Июль 30, 2023

Язык: Английский

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Mitochondrial dysfunction in neurodegenerative disorders: Potential therapeutic application of mitochondrial transfer to central nervous system-residing cells

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Сен. 9, 2023

Mitochondrial dysfunction is reiteratively involved in the pathogenesis of diverse neurodegenerative diseases. Current vitro and vivo approaches support that mitochondrial branded by several molecular cellular defects, whose impact at different levels including calcium iron homeostasis, energetic balance and/or oxidative stress, makes it difficult to resolve them collectively given their multifactorial nature. transfer offers an overall solution since contains replacement damage mitochondria healthy units. Therefore, this review provides introducing view on structure energy-related functions as well dynamics. In turn, we summarize current knowledge how these features are deregulated diseases, frontotemporal dementia, multiple sclerosis, amyotrophic lateral Friedreich ataxia, Alzheimer´s disease, Parkinson´s Huntington's disease. Finally, analyzed advances between cell types actively participate processes, they might be projected toward developing novel therapeutic strategies.

Язык: Английский

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Antioxidant Therapeutic Strategies in Neurodegenerative Diseases

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(16), С. 9328 - 9328

Опубликована: Авг. 19, 2022

The distinguishing pathogenic features of neurodegenerative diseases include mitochondrial dysfunction and derived reactive oxygen species generation. neural tissue is highly sensitive to oxidative stress this a prominent factor in both chronic acute neurodegeneration. Based on this, therapeutic strategies using antioxidant molecules towards redox equilibrium have been widely used for the treatment several brain pathologies. Globally, polyphenols, carotenes vitamins are among most typical exogenous agents that tested neurodegeneration as adjunctive therapies. However, other types antioxidants, including hormones, such melatonin, also considered neuroprotective different contexts. This review highlights relevant targets main disorders Alzheimer's disease, Parkinson's Huntington's disease less represented amyotrophic lateral sclerosis, well traumatic injury, while summarizing latest randomized placebo-controlled trials.

Язык: Английский

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Mitochondrial Dynamics in Neurodegenerative Diseases: Unraveling the Role of Fusion and Fission Processes

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13033 - 13033

Опубликована: Авг. 22, 2023

Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the progressive degeneration and death neurons, leading to range neurological symptoms. Despite heterogeneity these conditions, common denominator is implication mitochondrial dysfunction in their pathogenesis. Mitochondria play crucial role creating biomolecules, providing energy through adenosine triphosphate (ATP) generated oxidative phosphorylation (OXPHOS), producing reactive oxygen species (ROS). When they’re not functioning correctly, becoming fragmented losing membrane potential, they contribute diseases. In this review, we explore how mitochondria fuse undergo fission, especially context NDs. We discuss genetic protein mutations linked impact dynamics. also look at key regulatory proteins fusion (MFN1, MFN2, OPA1) fission (DRP1 FIS1), including post-translational modifications. Furthermore, highlight potential drugs that can influence By unpacking complex processes, aim direct research towards treatments improve life quality for people with challenging conditions.

Язык: Английский

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