Frontiers in Oncology,
Год журнала:
2021,
Номер
11
Опубликована: Дек. 1, 2021
Glioblastoma
represents
the
most
devastating
form
of
human
brain
cancer,
associated
with
a
very
poor
survival
rate
patients.
Unfortunately,
treatment
options
are
currently
limited
and
gold
standard
pharmacological
chemotherapeutic
drug
temozolomide
only
slightly
increases
rate.
Experimental
studies
have
shown
that
efficiency
can
be
improved
by
inducing
ferroptosis
–
recently
discovered
cell
death,
which
is
different
from
apoptosis,
necrosis,
or
necroptosis
and,
characterized
lipid
peroxidation
reactive
oxygen
species
accumulation.
Ferroptosis
also
activated
to
improve
malignant
stages
neuroblastoma,
meningioma,
glioma.
Due
their
role
in
cancer
treatment,
ferroptosis-gene
signatures
been
evaluated
for
ability
predict
Despite
positive
effects
during
chemotherapy,
drugs
used
induce
such
as
erastin
sorafenib
well
genetic
manipulation
key
players
cystine-glutamate
exchanger
xCT
glutathione
peroxidase
GPx4
impact
neuronal
function
cognitive
capabilities.
In
this
review,
we
give
an
update
on
tumors
summarize
healthy
tissues.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 11, 2024
Glioma,
an
aggressive
brain
tumor,
poses
a
challenge
in
understanding
the
mechanisms
of
treatment
resistance,
despite
promising
results
from
immunotherapy.
We
identified
genes
associated
with
immunotherapy
resistance
through
analysis
The
Cancer
Genome
Atlas
(TCGA),
Chinese
Glioma
(CGGA),
and
Gene
Expression
Omnibus
(GEO)
databases.
Subsequently,
qRT-PCR
western
blot
analyses
were
conducted
to
measure
mRNA
protein
levels
TBC1
Domain
Family
Member
1
(TBC1D1),
respectively.
Additionally,
Set
Enrichment
Analysis
(GSEA)
was
employed
reveal
relevant
signaling
pathways,
expression
TBC1D1
immune
cells
analyzed
using
single-cell
RNA
sequencing
(scRNA-seq)
data
GEO
database.
Tumor
Immune
Dysfunction
Exclusion
(TIDE)
database
utilized
assess
T-cell
function,
while
Immunotherapy
Resource
(TIGER)
evaluate
relation
TBC1D1.
Furthermore,
predictive
performance
molecules
on
prognosis
assessed
Kaplan-Meier
plots,
nomograms,
ROC
curves.
significantly
elevated
tumor
tissue
glioma
patients.
high
observed
macrophages
compared
other
cells,
which
negatively
impacted
T
cell
impaired
response,
promoted
tolerance,
led
poor
prognosis.
Inhibition
found
potentially
synergistically
enhance
efficacy
prolong
survival
cancer
patients
gliomas.
Heightened
may
facilitate
immunosuppressive
microenvironment
predict
Blocking
could
minimize
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Авг. 9, 2024
Gliomas
are
primary
tumors
that
originate
in
the
central
nervous
system.
The
conventional
treatment
options
for
gliomas
typically
encompass
surgical
resection
and
temozolomide
(TMZ)
chemotherapy.
However,
despite
aggressive
interventions,
median
survival
glioma
patients
is
merely
about
14.6
months.
Consequently,
there
an
urgent
necessity
to
explore
innovative
therapeutic
strategies
treating
glioma.
foundational
study
of
regulated
cell
death
(RCD)
can
be
traced
back
Karl
Vogt's
seminal
observations
cellular
demise
toads,
which
were
documented
1842.
In
past
decade,
Nomenclature
Committee
on
Cell
Death
(NCCD)
has
systematically
classified
delineated
various
forms
mechanisms
death,
synthesizing
morphological,
biochemical,
functional
characteristics.
primarily
manifests
two
forms:
accidental
(ACD),
caused
by
external
factors
such
as
physical,
chemical,
or
mechanical
disruptions;
RCD,
a
gene-directed
intrinsic
process
coordinates
orderly
response
both
physiological
pathological
cues.
Advancements
our
understanding
RCD
have
shed
light
manipulation
modulation
-
either
through
induction
suppression
potentially
groundbreaking
approach
oncology,
holding
significant
promise.
obstacles
persist
at
interface
research
clinical
application,
with
impediments
encountered
translating
modalities.
It
increasingly
apparent
integrative
examination
molecular
underpinnings
imperative
advancing
field,
particularly
within
framework
inter-pathway
synergy.
this
review,
we
provide
overview
including
autophagy-dependent
anoikis,
ferroptosis,
cuproptosis,
pyroptosis
immunogenic
death.
We
summarize
latest
advancements
regulate
interconnections
between
different
processes.
By
comprehending
these
connections
developing
targeted
strategies,
potential
enhance
therapy
RCD.
As
a
primary
brain
cancer,
glioma
presents
significant
challenges
in
treatment
and
prognosis.
Identifying
reliable
biomarkers
is
crucial
for
improving
patient
outcomes.
This
study
focuses
on
the
ABCC3
gene,
exploring
its
function
as
standalone
predictive
indictor
correlation
with
immune
infiltration
resistance
to
chemotherapy
glioma.
A
multi-faceted
approach
was
adopted
this
analysis.
We
scrutinized
RNA
expression
patterns
of
gene
across
spectrum
cancer
types,
concentrated
focus
Our
methodological
arsenal
included
bioinformatics
analysis,
immunohistochemistry
(ICH),
western
blot
(WB),
cell
counting
Kit-8
(CCK8)
assays.
These
techniques
were
instrumental
gauging
prognostic
impact
elucidating
associations
resistance.
The
investigation
revealed
elevated
levels
high
grade
(HGG)
tissues
compared
lower
(LGG)
tissues.
Notably,
upregulation
associated
shorter
overall
survival
patients
Furthermore,
emerged
an
independent
factor
prognostication,
capability
1-,
3-,
5-year
rates.
far
response
concerned,
ABCC3's
correlates
positively
several
cells
checkpoint
genes.
also
uncovered
role
drug
resistance,
particularly
regarding
temozolomide
(TMZ),
therapeutic
agent
treatment.
reveals
biomarker
glioma,
survival,
enhanced
infiltration,
increased
chemotherapy.
findings
emphasize
promise
novel
target
therapies.
Background
Multiple
myeloma
(MM)
is
a
hematological
malignancy
with
the
proliferation
of
malignant
plasma
cells.
Numerous
studies
have
highlighted
critical
role
ferroptosis
in
MM.
However,
how
to
use
ferroptosis-related
genes
(FRGs)
for
prognostic
prediction
and
treatment
guidance
MM
remains
unknown.
Frontiers in Oncology,
Год журнала:
2021,
Номер
11
Опубликована: Дек. 1, 2021
Glioblastoma
represents
the
most
devastating
form
of
human
brain
cancer,
associated
with
a
very
poor
survival
rate
patients.
Unfortunately,
treatment
options
are
currently
limited
and
gold
standard
pharmacological
chemotherapeutic
drug
temozolomide
only
slightly
increases
rate.
Experimental
studies
have
shown
that
efficiency
can
be
improved
by
inducing
ferroptosis
–
recently
discovered
cell
death,
which
is
different
from
apoptosis,
necrosis,
or
necroptosis
and,
characterized
lipid
peroxidation
reactive
oxygen
species
accumulation.
Ferroptosis
also
activated
to
improve
malignant
stages
neuroblastoma,
meningioma,
glioma.
Due
their
role
in
cancer
treatment,
ferroptosis-gene
signatures
been
evaluated
for
ability
predict
Despite
positive
effects
during
chemotherapy,
drugs
used
induce
such
as
erastin
sorafenib
well
genetic
manipulation
key
players
cystine-glutamate
exchanger
xCT
glutathione
peroxidase
GPx4
impact
neuronal
function
cognitive
capabilities.
In
this
review,
we
give
an
update
on
tumors
summarize
healthy
tissues.
