Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction DOI Creative Commons
Marc Dahlmanns, Eduard Yakubov, Jana Katharina Dahlmanns

и другие.

Frontiers in Oncology, Год журнала: 2021, Номер 11

Опубликована: Дек. 1, 2021

Glioblastoma represents the most devastating form of human brain cancer, associated with a very poor survival rate patients. Unfortunately, treatment options are currently limited and gold standard pharmacological chemotherapeutic drug temozolomide only slightly increases rate. Experimental studies have shown that efficiency can be improved by inducing ferroptosis – recently discovered cell death, which is different from apoptosis, necrosis, or necroptosis and, characterized lipid peroxidation reactive oxygen species accumulation. Ferroptosis also activated to improve malignant stages neuroblastoma, meningioma, glioma. Due their role in cancer treatment, ferroptosis-gene signatures been evaluated for ability predict Despite positive effects during chemotherapy, drugs used induce such as erastin sorafenib well genetic manipulation key players cystine-glutamate exchanger xCT glutathione peroxidase GPx4 impact neuronal function cognitive capabilities. In this review, we give an update on tumors summarize healthy tissues.

Язык: Английский

Novel prognostic biomarker TBC1D1 is associated with immunotherapy resistance in gliomas DOI Creative Commons

Daqiang Song,

Qian Yang, Liuying Li

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Март 11, 2024

Glioma, an aggressive brain tumor, poses a challenge in understanding the mechanisms of treatment resistance, despite promising results from immunotherapy. We identified genes associated with immunotherapy resistance through analysis The Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA), and Gene Expression Omnibus (GEO) databases. Subsequently, qRT-PCR western blot analyses were conducted to measure mRNA protein levels TBC1 Domain Family Member 1 (TBC1D1), respectively. Additionally, Set Enrichment Analysis (GSEA) was employed reveal relevant signaling pathways, expression TBC1D1 immune cells analyzed using single-cell RNA sequencing (scRNA-seq) data GEO database. Tumor Immune Dysfunction Exclusion (TIDE) database utilized assess T-cell function, while Immunotherapy Resource (TIGER) evaluate relation TBC1D1. Furthermore, predictive performance molecules on prognosis assessed Kaplan-Meier plots, nomograms, ROC curves. significantly elevated tumor tissue glioma patients. high observed macrophages compared other cells, which negatively impacted T cell impaired response, promoted tolerance, led poor prognosis. Inhibition found potentially synergistically enhance efficacy prolong survival cancer patients gliomas. Heightened may facilitate immunosuppressive microenvironment predict Blocking could minimize

Язык: Английский

Процитировано

3

Revisiting the potential of regulated cell death in glioma treatment: a focus on autophagy-dependent cell death, anoikis, ferroptosis, cuproptosis, pyroptosis, immunogenic cell death, and the crosstalk between them DOI Creative Commons

Maowen Luo,

Xingzhao Luan,

Chaoge Yang

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Авг. 9, 2024

Gliomas are primary tumors that originate in the central nervous system. The conventional treatment options for gliomas typically encompass surgical resection and temozolomide (TMZ) chemotherapy. However, despite aggressive interventions, median survival glioma patients is merely about 14.6 months. Consequently, there an urgent necessity to explore innovative therapeutic strategies treating glioma. foundational study of regulated cell death (RCD) can be traced back Karl Vogt's seminal observations cellular demise toads, which were documented 1842. In past decade, Nomenclature Committee on Cell Death (NCCD) has systematically classified delineated various forms mechanisms death, synthesizing morphological, biochemical, functional characteristics. primarily manifests two forms: accidental (ACD), caused by external factors such as physical, chemical, or mechanical disruptions; RCD, a gene-directed intrinsic process coordinates orderly response both physiological pathological cues. Advancements our understanding RCD have shed light manipulation modulation - either through induction suppression potentially groundbreaking approach oncology, holding significant promise. obstacles persist at interface research clinical application, with impediments encountered translating modalities. It increasingly apparent integrative examination molecular underpinnings imperative advancing field, particularly within framework inter-pathway synergy. this review, we provide overview including autophagy-dependent anoikis, ferroptosis, cuproptosis, pyroptosis immunogenic death. We summarize latest advancements regulate interconnections between different processes. By comprehending these connections developing targeted strategies, potential enhance therapy RCD.

Язык: Английский

Процитировано

3

Analysis of ABCC3 in glioma progression: implications for prognosis, immunotherapy, and drug resistance DOI Creative Commons
Liang Shen, Haitao Shen, Tong Wang

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 13, 2025

As a primary brain cancer, glioma presents significant challenges in treatment and prognosis. Identifying reliable biomarkers is crucial for improving patient outcomes. This study focuses on the ABCC3 gene, exploring its function as standalone predictive indictor correlation with immune infiltration resistance to chemotherapy glioma. A multi-faceted approach was adopted this analysis. We scrutinized RNA expression patterns of gene across spectrum cancer types, concentrated focus Our methodological arsenal included bioinformatics analysis, immunohistochemistry (ICH), western blot (WB), cell counting Kit-8 (CCK8) assays. These techniques were instrumental gauging prognostic impact elucidating associations resistance. The investigation revealed elevated levels high grade (HGG) tissues compared lower (LGG) tissues. Notably, upregulation associated shorter overall survival patients Furthermore, emerged an independent factor prognostication, capability 1-, 3-, 5-year rates. far response concerned, ABCC3's correlates positively several cells checkpoint genes. also uncovered role drug resistance, particularly regarding temozolomide (TMZ), therapeutic agent treatment. reveals biomarker glioma, survival, enhanced infiltration, increased chemotherapy. findings emphasize promise novel target therapies.

Язык: Английский

Процитировано

0

Identification of RUVBL2 as a novel biomarker to predict the prognosis and drug sensitivity in multiple myeloma based on ferroptosis genes DOI Creative Commons

Sishi Tang,

Xinyi Long,

Fangfang Li

и другие.

Hematology, Год журнала: 2025, Номер 30(1)

Опубликована: Фев. 21, 2025

Background Multiple myeloma (MM) is a hematological malignancy with the proliferation of malignant plasma cells. Numerous studies have highlighted critical role ferroptosis in MM. However, how to use ferroptosis-related genes (FRGs) for prognostic prediction and treatment guidance MM remains unknown.

Язык: Английский

Процитировано

0

Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction DOI Creative Commons
Marc Dahlmanns, Eduard Yakubov, Jana Katharina Dahlmanns

и другие.

Frontiers in Oncology, Год журнала: 2021, Номер 11

Опубликована: Дек. 1, 2021

Glioblastoma represents the most devastating form of human brain cancer, associated with a very poor survival rate patients. Unfortunately, treatment options are currently limited and gold standard pharmacological chemotherapeutic drug temozolomide only slightly increases rate. Experimental studies have shown that efficiency can be improved by inducing ferroptosis – recently discovered cell death, which is different from apoptosis, necrosis, or necroptosis and, characterized lipid peroxidation reactive oxygen species accumulation. Ferroptosis also activated to improve malignant stages neuroblastoma, meningioma, glioma. Due their role in cancer treatment, ferroptosis-gene signatures been evaluated for ability predict Despite positive effects during chemotherapy, drugs used induce such as erastin sorafenib well genetic manipulation key players cystine-glutamate exchanger xCT glutathione peroxidase GPx4 impact neuronal function cognitive capabilities. In this review, we give an update on tumors summarize healthy tissues.

Язык: Английский

Процитировано

20