Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(1), С. 8 - 8
Опубликована: Янв. 1, 2025
Each
year,
the
number
of
cases
strokes
and
deaths
due
to
this
is
increasing
around
world.
This
could
be
work
stress,
lifestyles,
unhealthy
food
habits,
several
other
reasons.
Currently,
there
are
traditional
methods
like
thrombolysis
mechanical
thrombectomy
for
managing
strokes.
The
current
approach
has
limitations,
delayed
diagnosis,
limited
therapeutic
delivery,
risks
secondary
injuries.
So,
a
need
some
effective
reliable
management
strokes,
which
help
in
early
diagnosis
followed
by
treatment
Nanotechnology
played
an
immense
role
recently,
it
emerged
as
transformative
solution
offering
innovative
diagnostic
tools
strategies.
Nanoparticles
(NPs)
belonging
classes,
including
metallic
(metallic
metal
oxide),
organic
(lipids,
liposome),
carbon,
can
cross
blood–brain
barrier
may
exhibit
potential
various
Moreover,
these
NPs
have
exhibited
promise
improving
imaging
specificity
delivery
precise
drug
real-time
monitoring
efficacy.
Nanomaterials
cerium
oxide
(CeO2)
liposome-encapsulated
agents
neuroprotective
properties
that
reduce
oxidative
stress
promote
neuroregeneration.
In
present
article,
authors
emphasized
significant
advancements
nanomedicine
stroke,
NPs-based
systems,
neuroregenerative
therapies,
multimodal
advancements.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1130 - 1130
Опубликована: Янв. 28, 2025
Oxidative
stress
plays
a
role
in
various
pathophysiological
diseases,
including
neurogenerative
such
as
Alzheimer′s
disease
(AD),
which
is
the
most
prevalent
neuro-pathology
aging
population.
has
been
reported
to
be
one
of
earliest
pathological
alterations
AD.
Additionally,
it
was
demonstrated
that
older
adults,
there
loss
free
radical
scavenging
ability.
The
Nrf2
transcription
factor
key
regulator
antioxidant
defense
systems,
but,
with
aging,
both
amount
and
transcriptional
activity
decrease.
With
available
treatments
for
AD
being
poorly
effective,
reinforcing
systems
via
pathway
may
way
prevent
treat
To
highlight
predominant
signaling
defending
against
oxidative
and,
therefore,
neurotoxicity,
we
present
an
overview
natural
compounds
exert
their
own
neuroprotective
roles
through
activation
pathway.
This
review
opportunity
promote
holistic
approach
treatment
need
further
refine
development
new
potential
Nrf2-targeting
drugs.
Biomedical Technology,
Год журнала:
2024,
Номер
7, С. 32 - 45
Опубликована: Июль 16, 2024
Ischemic
stroke
(IS),
a
major
cause
of
death
and
disability
globally,
requires
innovative
therapeutic
approaches
due
to
its
complex
pathology.
Nature
medicine
(NM)
offers
promising
treatments
through
bioactive
compounds,
which
target
the
multifaceted
nature
stroke-induced
damage.
However,
clinical
application
NM
is
limited
by
challenges
in
bioavailability
specificity.
This
review
article
presents
an
advanced
perspective
on
integrating
nanotechnology
with
create
potent
nanodelivery
systems
for
ischemic
treatment.
We
highlight
pathological
underpinnings
stroke,
including
oxidative
stress,
inflammation,
apoptosis,
discuss
how
compounds
offer
targeted
mitigation
strategies.
By
incorporating
platforms,
such
as
liposomes
nanoparticles,
these
-based
can
achieve
enhanced
targeting,
solubility,
controlled
release,
significantly
improving
outcomes
while
reducing
side
effects.
Despite
developments,
translation
nano-enhanced
into
practice
faces
obstacles,
manufacturing
scalability,
regulatory
approval,
safety
evaluations.
emphasizes
potential
combining
advance
therapy,
calling
integrated
research
efforts
overcome
existing
barriers
fully
realize
benefits
this
approach.
Psychiatry and Clinical Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Aims
Effective
intervention
for
mild
cognitive
impairment
(MCI)
is
key
preventing
dementia.
As
a
neuroprotective
agent,
butylphthalide
has
the
potential
to
treat
MCI
due
Alzheimer
disease
(AD).
However,
pharmacological
mechanism
of
from
brain
network
perspective
not
clear.
Therefore,
we
aimed
investigate
multimodal
changes
associated
with
treatment
in
AD.
Methods
A
total
270
patients
AD
received
either
or
placebo
at
ratio
1:1
1
year.
was
defined
as
decrease
Alzheimer's
Disease
Assessment
Scale‐Cognitive
Subscale
(ADAS‐cog)
>
2.5.
Brain
networks
were
constructed
using
T1‐magnetic
resonance
imaging
and
fluorodeoxyglucose
positron
emission
tomography.
support
vector
machine
applied
develop
predictive
models.
Results
Both
(drug
vs.
placebo)‐time
interactions
efficacy
(effective
ineffective)‐time
detected
on
some
overlapping
structural
metrics.
Simple
effects
analyses
revealed
significantly
increased
global
efficiency
under
both
effective
butylphthalide.
Among
metrics,
an
degree
centrality
left
paracentral
lobule
related
poorer
improvement.
The
model
based
baseline
metrics
exhibited
high
accuracy
(88.93%)
predicting
butylphthalide's
efficacy.
Conclusion
Butylphthalide
may
restore
abnormal
organization
AD,
could
be
markers
therapeutic
Clinical
Trial
Registration
This
study
registered
Chinese
Registry
(Registration
Number:
ChiCTR1800018362,
Date:
2018‐09‐13).
Medicinal Research Reviews,
Год журнала:
2023,
Номер
44(3), С. 975 - 1012
Опубликована: Дек. 21, 2023
Ischemic
stroke
(IS)
poses
a
significant
threat
to
global
human
health
and
life.
In
recent
decades,
we
have
witnessed
unprecedented
progresses
against
IS,
including
thrombolysis,
thrombectomy,
few
medicines
that
can
assist
in
reopening
the
blocked
brain
vessels
or
serve
as
standalone
treatments
for
patients
who
are
not
eligible
thrombolysis/thrombectomy
therapies.
However,
narrow
time
windows
of
thrombolysis/thrombectomy,
coupled
with
risk
hemorrhagic
transformation,
well
lack
highly
effective
safe
medications,
continue
present
big
challenges
acute
treatment
long-term
recovery
IS.
past
3
years,
several
excellent
articles
reviewed
pathophysiology
IS
therapeutic
based
on
pathophysiology.
Regretfully,
there
is
no
comprehensive
overview
summarize
all
categories
anti-IS
drugs/agents
designed
synthesized
molecular
mechanisms
From
medicinal
chemistry
view
point,
this
article
reviews
multitude
drugs/agents,
small
molecule
compounds,
natural
products,
peptides,
others,
which
been
developed
mechanism
pathophysiology,
such
excitotoxicity,
oxidative/nitrosative
stresses,
cell
death
pathways,
neuroinflammation,
so
forth.
addition,
emerging
strategies,
nanomedicines,
stem
therapy
noncoding
RNAs,
recently
appeared
shortly
introduced.
Finally,
perspectives
associated
future
directions
briefly
provided
move
field
forward.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
174, С. 116428 - 116428
Опубликована: Апрель 9, 2024
Vascular
cognitive
impairment
(VCI)
encompasses
a
range
of
deficits
arising
from
vascular
pathology.
The
pathophysiological
mechanisms
underlying
VCI
remain
incompletely
understood;
however,
chronic
cerebral
hypoperfusion
(CCH)
is
widely
acknowledged
as
principal
pathological
contributor.
Mitochondria,
crucial
for
cellular
energy
production
and
intracellular
signaling,
can
lead
to
numerous
neurological
impairments
when
dysfunctional.
Recent
evidence
indicates
that
mitochondrial
dysfunction—marked
by
oxidative
stress,
disturbed
calcium
homeostasis,
compromised
mitophagy,
anomalies
in
dynamics—plays
pivotal
role
pathogenesis.
This
review
offers
detailed
examination
the
latest
insights
into
dysfunction
within
context,
focusing
on
both
origins
consequences
health.
It
aims
lay
robust
scientific
groundwork
guiding
development
refinement
mitochondrial-targeted
interventions
VCI.
CNS Neuroscience & Therapeutics,
Год журнала:
2022,
Номер
28(11), С. 1706 - 1717
Опубликована: Сен. 1, 2022
Current
evidence
for
the
efficacy
of
pharmacological
treatment
in
improving
cognitive
function
is
absent.
Recent
studies
have
reported
that
3-n-butylphthalide
(NBP)
has
a
positive
effect
on
impairment;
however,
its
clinical
and
safety
unclear.
Therefore,
we
conducted
meta-analysis
to
assess
impairment.
Heliyon,
Год журнала:
2024,
Номер
10(5), С. e27644 - e27644
Опубликована: Март 1, 2024
Doxorubicin
(DOX)
is
a
widely
used
chemotherapeutic
drug
known
to
cause
dose-dependent
myocardial
toxicity,
which
limits
its
clinical
potential.
DL-3-n-butylphthalide
(NBP),
substance
extracted
from
celery
seed
species,
has
number
of
pharmacological
properties,
such
as
antioxidant,
anti-inflammatory,
and
anti-apoptotic
actions.
However,
whether
NBP
can
protect
against
DOX-induced
acute
toxicity
still
unclear.
Therefore,
this
study
was
designed
investigate
the
potential
protective
effects
injury
underlying
mechanism.
By
injecting
15
mg/kg
DOX
intraperitoneally,
eight-week-old
male
C57BL6
mice
suffered
an
injury.
The
treatment
group
received
80
by
gavage
once
daily
for
14
days.
To
mimic
cardiotoxicity
DOX,
1uM
administered
H9C2
cells
in
vitro.
In
comparison
group,
results
showed
that
improved
cardiac
function
decreased
serum
levels
cTnI,
LDH,
CK-MB.
Additionally,
HE
staining
demonstrated
attenuated
fibrillar
lysis
breakage
DOX-treated
mouse
hearts.
Western
blotting
assay
immunofluorescence
suggested
oxidative
stress,
apoptosis,
inflammation
both
vivo
Mechanistically,
significantly
upregulated
Nrf2/HO-1
signaling
pathway,
while
Nrf2
inhibitor
ML385
prevented
protecting
myocardium
conclusion,
Our
indicate
alleviates
activating
pathway.
