M2 microglia-derived exosomes reduce neuronal ferroptosis via FUNDC1-mediated mitophagy by activating AMPK/ULK1 signaling DOI Creative Commons
Jian Li, Qing Chen,

Hao Gu

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 23, 2025

Язык: Английский

Advances in the Study of Mitophagy in Renal Ischemia–Reperfusion Injury DOI Creative Commons

Rumeng Li,

Xiaofeng Zhu,

Becky Lou

и другие.

Engineering Reports, Год журнала: 2025, Номер 7(4)

Опубликована: Апрель 1, 2025

ABSTRACT Renal ischemia–reperfusion injury (IRI) is a leading etiology of acute kidney (AKI), predominantly observed in complex cardiovascular surgeries, severe traumatic shock, and renal transplantation. Oxidative stress, calcium overload, mitochondrial dysfunction, autophagy, apoptosis are closely associated with IRI. Mitochondria not only serve as critical organelles for cellular oxidative respiration energy production but also play vital roles various biochemical processes including homeostasis, signal transduction, metabolism, cell differentiation, apoptosis, ischemia, reinjury. One particular form mitophagy, can accurately eliminate damaged or defective mitochondria, thereby maintaining homeostasis playing key role To give new approach to mechanistic research clinical prevention therapy injury, this paper examines the signaling pathways novel therapeutic targets mitophagy injury.

Язык: Английский

Процитировано

0
A prospective cohort study on serum PINK1 as a biochemical marker in relation to poor neurological prognosis, stroke-associated pneumonia and early neurological deterioration after acute intracerebral hemorrhage DOI
Wen‐Fei Ni,

Chen Si-hua,

Le Cao Dai

и другие.

Clinica Chimica Acta, Год журнала: 2025, Номер unknown, С. 120282 - 120282

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Genetically engineered BMSCs promote dopamine secretion and ameliorate motor dysfunction in a Parkinson’s disease rat model DOI Creative Commons
Chunjing Wang, Yang Liu,

Junyan Chang

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 11, 2025

Regenerative therapy based on mesenchymal stem cells (MSCs) is regarded as a promising strategy for treating Parkinson's disease (PD). Previous studies have shown that cell transplantation has the potential to treat disease, but its specific mechanism of action still unclear. In present study, we generate genetically engineered bone marrow (BMSCs) encoding three critical genes (TH, DDC, and GCH1) dopamine synthesis (DA-BMSCs). The DA-BMSCs maintain their MSCs characteristics stable ability secrete after passage. Moreover, survived functioned in rat model PD treated with 6-OHDA 8 weeks transplantation. Histological showed could differentiate into various functional neurons astrocytes, derived mature dopaminergic extended dense neurites host striatum. Importantly, promoted reconstruction midbrain pathways by upregulating striatal 5-HT levels downregulating inflammatory factors including IL-6, TNF-α, IL-10. These findings suggest may be an attractive donor material disease.

Язык: Английский

Процитировано

0
Mitophagy in Brain Injuries: Mechanisms, Roles, and Therapeutic Potential DOI Creative Commons

Jiayu Tian,

Yanna Mao, Di Liu

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Язык: Английский

Процитировано

0
M2 microglia-derived exosomes reduce neuronal ferroptosis via FUNDC1-mediated mitophagy by activating AMPK/ULK1 signaling DOI Creative Commons
Jian Li, Qing Chen,

Hao Gu

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 23, 2025

Язык: Английский

Процитировано

0