Sleep Medicine, Год журнала: 2024, Номер 126, С. 114 - 121
Опубликована: Дек. 4, 2024
Язык: Английский
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(2)
Опубликована: Фев. 1, 2024
The aim of this study is to investigate differences in gray matter volume and cortical complexity between Parkinson's disease with depression (PDD) patients without (PDND) patients.
Язык: Английский
Процитировано
10
Computers in Human Behavior, Год журнала: 2025, Номер unknown, С. 108582 - 108582
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Neuroreport, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Previous neuroimaging studies have identified functional and structural changes in the gray matter of rhegmatogenous retinal detachment (RRD) patients, yet genetic mechanisms behind these alterations remain unclear. We employed multimodal imaging to investigate RRD patients. A transcriptome-neuroimaging spatial correlation analysis, integrating gene expression data from Allen Human Brain Atlas, genes linked stability changes. followed this with enrichment, protein–protein interaction (PPI) network mapping, profiling. patients showed distinct, sustained dynamic balance within default mode functionally, a significant reduction volume visual region structurally, compared healthy controls. Transcriptome-neuroimaging analysis revealed link between profiles 165 involved membrane organization, neurodegeneration, phagocytosis, calcium signaling. These form highly interconnected PPI network, centered around key hub genes. Tissue- cell-specific highlighted distinct pattern, especially D1 receptor–positive cells caudate-putamen. Our findings indicate function structure particularly regions cognitive processing. Transcriptomic reveals that are multiple genes, shedding light on potential underlying RRD-associated modifications offering new insights for treatment prognosis.
Язык: Английский
Процитировано
0
Опубликована: Март 30, 2025
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder traditionally defined by its motor symptoms yet increasingly recognized for wide spectrum of neuropsychiatric (NPS) including anxiety, depression, apathy, impulse-control behaviors, and hallucinations. Recent neuroimaging advances have provided crucial insights into the neural substrates underlying these comorbidities. Structural imaging studies, using voxel-based morphometry T1-weighted magnetic resonance imaging, revealed regional atrophy in frontal cortex, striatum, limbic areas, occipital regions. In comparison, functional positron emission tomography, single-photon computed resting-state MRI identified abnormal network connectivity circuits implicated fear processing, reward regulation, cognitive control. Overall, studies suggest shared distinct pathophysiology PD-related NPS, emphasizing need longitudinal, multimodal investigations to inform targeted therapeutic strategies improve clinical outcomes.
Язык: Английский
Процитировано
0
Behavioural Brain Research, Год журнала: 2025, Номер unknown, С. 115622 - 115622
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Ноя. 28, 2024
The topological attributes of structural covariance networks (SCNs) based on fractal dimension (FD) and changes in brain network connectivity were investigated using graph theory network-based statistics (NBS) patients with noise-induced hearing loss (NIHL). High-resolution 3D T1 images 40 NIHL 38 healthy controls (HCs) analyzed. FD-based Pearson correlation coefficients calculated converted to Fisher's Z construct the SCNs. Topological hubs theory. measures between groups compared nonparametric permutation tests. Abnormal connection identified NBS analysis. group showed a significantly increased normalized clustering coefficient, characteristic path length, decreased nodal efficiency right medial orbitofrontal gyrus. Additionally, betweenness centrality degree both transverse temporal gyrus left parahippocampal group. analysis revealed two subnetworks abnormal connections. subnetwork enhanced connections was mainly distributed default mode, frontoparietal, dorsal attention, somatomotor networks, whereas reduced limbic, visual, auditory networks. These findings demonstrate structure SCNs NIHL, which may contribute understand complex mechanisms damage at level, providing new theoretical basis for neuropathological mechanisms.
Язык: Английский
Процитировано
1
European Journal of Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Дек. 3, 2024
Based on motor symptoms, Parkinson's disease (PD) can be classified into tremor dominant (TD) and postural instability gait difficulty (PIGD) subtypes. Few studies have examined cortical complexity differences in PD This study aimed to investigate grey matter volume (GMV) between TD PIGD. We enrolled 36 patients, 27 PIGD patients 66 healthy controls (HC) from the PPMI (Parkinson's Progression Markers Initiative) database. Voxel-based morphometry (VBM) surface-based (SBM) were utilized assess GMV, thickness complexity. The structural MRI data of participants was analysed using CAT12/SPM12 (p < 0.05, FDR corrected). Additionally, correlations clinical changes Holm-Bonferroni In comparison both HC groups, exhibited a significant fractal dimension (FD) decrease many regions. A negative correlation age FD observed left insula for bilateral patients. However, no found or other indices. Altered indicates that disturbances may result failure integrate information various structures, whereas parkinsonian rest is not associated with this integration. Also, widespread decreases demonstrate more sensitive than measures serve as novel biomarker identifying subtle morphology subtype.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 6, 2024
Background: Based on motor symptoms, Parkinson's disease (PD) can be classified into tremor dominant (TD) and postural instability gait difficulty (PIGD) subtypes. This study aimed to investigate differences in cortical complexity gray matter volume (GMV) between TD PIGD. Methods: We enrolled 36 patients, 27 PIGD 66 healthy controls (HC) from the PPMI (Parkinson's Progression Markers Initiative) database. Voxel-based morphometry (VBM) surface-based (SBM) were utilized assess GMV, thickness, complexity. Additionally, correlations clinical data structural changes examined. Results: In comparison with HCs, patients exhibited a significant fractal dimension (FD) decrease many regions, such as bilateral insula, right superior temporal, left rostral middle frontal. Moreover, showed FD reduction various including supramarginal gyrus, lateral orbitofrontal temporal occipital compared group. A negative correlation age was observed insula for patients. However, no found or other indices. Conclusion: Altered FD, particularly indicates that disturbances PD may result failure integrate information structures, whereas parkinsonian is not associated this integration.
Язык: Английский
Процитировано
0
Cerebral Cortex, Год журнала: 2024, Номер 34(10)
Опубликована: Окт. 1, 2024
Parkinson's disease is characterized by multiple neurotransmitter systems beyond the traditional dopaminergic pathway, yet their influence on volumetric alterations not well comprehended. We included 72 de novo, drug-naïve patients and 61 healthy controls. Voxel-wise gray matter volume was evaluated between controls, as among subgroups categorized clinical manifestations. The Juspace toolbox utilized to explore spatial relationship atrophy distribution. exhibited widespread GM in cerebral cerebellar regions, with correlations various receptors (FDR-P < 0.05). Cognitively impaired showed left middle temporal atrophy, which associated serotoninergic, dopaminergic, cholinergic, glutamatergic Postural gait disorder right precuneus, correlated gamma-aminobutyric acid, opioid Patients anxiety superior orbital frontal region; those depression lingual inferior occipital regions. Both conditions were linked serotoninergic regional a significant distribution of specific neurotransmitters, might provide insights into underlying pathophysiology manifestations develop targeted intervention strategies.
Язык: Английский
Процитировано
0
Sleep Medicine, Год журнала: 2024, Номер 126, С. 114 - 121
Опубликована: Дек. 4, 2024
Язык: Английский
Процитировано
0