Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis?
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(3)
Опубликована: Март 1, 2024
Abstract
Background
Accumulation
of
amyloid
beta,
tau
hyperphosphorylation,
and
microglia
activation
are
the
three
highly
acknowledged
pathological
factors
Alzheimer's
disease
(AD).
However,
oligodendrocytes
(OLs)
were
also
widely
investigated
in
pathogenesis
treatment
for
AD.
Aims
We
aimed
to
update
regulatory
targets
differentiation
maturation
OLs,
emphasized
key
role
OLs
occurrence
Methods
This
review
first
concluded
OL
with
AD
pathogenesis,
then
advanced
based
on
both
clinic
basic
experiments.
Later,
we
extensively
discussed
possible
application
current
progress
diagnosis
this
complex
disease.
Results
Molecules
involving
OLs’
or
maturation,
including
various
transcriptional
factors,
cholesterol
homeostasis
regulators,
microRNAs
could
participate
Clinical
data
point
towards
impairment
patients.
Basic
research
further
supports
central
regulation
pathologies.
Additionally,
classic
drugs,
donepezil,
edaravone,
fluoxetine,
clemastine
demonstrate
their
potential
remedying
models,
new
therapeutics
from
perspective
is
constantly
being
developed.
Conclusions
believe
that
dysfunction
one
important
Factors
regulating
might
be
biomarkers
early
agents
stimulating
warrant
development
anti‐AD
drugs.
Язык: Английский
Electroacupuncture promotes oligodendrocyte differentiation and myelin repair in a rat model of vascular dementia: Investigation of the mechanism from NF-κB-mediated inflammation
Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Comparative mapping of single‐cell transcriptomic landscapes in neurodegenerative diseases
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
21(5)
Опубликована: Май 1, 2025
Abstract
INTRODUCTION
Alzheimer's
disease
(AD),
dementia
with
Lewy
bodies
(DLB),
and
Parkinson's
(PD)
represent
a
spectrum
of
neurodegenerative
diseases
(NDDs).
Here,
we
performed
the
first
direct
comparison
their
transcriptomic
landscapes.
METHODS
We
profiled
whole
transcriptomes
NDD
cortical
tissue
by
single‐nucleus
RNA
sequencing,
using
computational
analyses
to
identify
common
distinct
differentially
expressed
genes
(DEGs),
pathways,
vulnerable
disease‐driver
cell
subtypes,
altered
cell‐to‐cell
interactions.
RESULTS
The
same
inhibitory
neuron
subtype
was
depleted
in
both
AD
DLB.
Potentially
disease‐driving
neuronal
subtypes
were
identified
PD
Cell–cell
communication
predicted
be
increased
but
decreased
DLB
PD.
DEGs
most
commonly
shared
across
NDDs
within
subtypes.
Overall,
showed
greatest
divergence,
while
exhibited
an
intermediate
signature.
DISCUSSION
These
results
may
help
explain
clinicopathological
these
provide
unique
insights
into
molecular
mechanisms
underlying
pathogenesis.
Highlights
population
(AD)
(DLB).
discovered
Differentially
types.
had
showing
Язык: Английский
The Role of Oligodendrocytes in Neurodegenerative Diseases: Unwrapping the Layers
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(10), С. 4623 - 4623
Опубликована: Май 12, 2025
Neurodegenerative
diseases
(NDs),
including
Alzheimer's
disease,
Parkinson's
amyotrophic
lateral
sclerosis/motor
neuron
and
multiple
sclerosis,
are
characterized
by
progressive
loss
of
neuronal
structure
function,
leading
to
severe
cognitive,
motor,
behavioral
impairments.
They
pose
a
significant
growing
challenge
due
their
rising
prevalence
impact
on
global
health
systems.
The
societal
emotional
toll
patients,
caregivers,
healthcare
infrastructures
is
considerable.
While
progress
has
been
made
in
elucidating
the
pathological
hallmarks
these
disorders,
underlying
cellular
molecular
mechanisms
remain
incompletely
understood.
Increasing
evidence
implicates
oligodendrocytes
progenitors-oligodendrocyte
progenitor
cells
(OPCs)-in
pathogenesis
several
NDs,
beyond
traditionally
recognized
role
demyelinating
conditions
such
as
MS.
Oligodendrocytes
essential
for
axonal
myelination,
metabolic
support,
neural
circuit
modulation
central
nervous
system.
Disruptions
oligodendrocyte
function
myelin
integrity-manifesting
demyelination,
hypomyelination,
or
dysmyelination-have
associated
with
disease
progression
various
neurodegenerative
contexts.
This
review
consolidates
recent
findings
OPCs
explores
concept
plasticity,
discusses
therapeutic
strategies
targeting
dysfunction.
By
highlighting
emerging
research
biology,
this
aims
provide
short
overview
its
relevance
potential
advances.
Язык: Английский
Molecular profiling of a rat model of vascular dementia: Evidences from proteomics, metabolomics and experimental validations
Brain Research,
Год журнала:
2024,
Номер
1846, С. 149254 - 149254
Опубликована: Сен. 26, 2024
Язык: Английский
Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases
Опубликована: Дек. 18, 2024
ABSTRACT
INTRODUCTION
Alzheimer’s
disease
(AD),
Dementia
with
Lewy
bodies
(DLB),
and
Parkinson’s
(PD)
represent
a
spectrum
of
neurodegenerative
disorders
(NDDs).
Here,
we
performed
the
first
direct
comparison
their
transcriptomic
landscapes.
METHODS
We
profiled
whole
transcriptomes
NDD
cortical
tissue
by
snRNA-seq.
used
computational
analyses
to
identify
common
distinct
differentially
expressed
genes
(DEGs),
biological
pathways,
vulnerable
disease-driver
cell
subtypes,
alteration
in
cell-to-cell
interactions.
RESULTS
The
same
inhibitory
neuron
subtype
was
depleted
both
AD
DLB.
Potentially
disease-driving
neuronal
subtypes
were
present
PD
Cell-cell
communication
predicted
be
increased
but
decreased
DLB
PD.
DEGs
most
commonly
shared
across
NDDs
within
subtypes.
Overall,
observed
greatest
divergence
between
PD,
while
exhibited
an
intermediate
signature.
DISCUSSION
These
results
help
explain
clinicopathological
this
group
provide
unique
insights
into
molecular
mechanisms
underlying
pathogenesis
NDDs.
Язык: Английский
Role of non-neuronal cells in neurorepair: a focus on proteinopathy and neurodegeneration
Regenerative medicine reports .,
Год журнала:
2024,
Номер
1(1), С. 31 - 51
Опубликована: Сен. 1, 2024
Despite
advances
in
biomedicine,
therapies
that
prevent
neuronal
loss
have
not
been
effective.
Several
strategies
targeting
the
defining
markers
of
main
neurodegenerative
diseases,
such
as
amyloid
beta
or
tau,
which
are
pivotal
Alzheimer’s
disease
frontotemporal
dementia,
α-synuclein,
leading
actor
Parkinson’s
disease,
shown
limited
success.
Nevertheless,
these
proteins
do
act
only
neurons
but
also
part
a
network
involving
non-neuronal
brain
cells,
astrocytes,
microglia
and
oligodendrocytes,
well
peripheral
immune
system.
In
this
review,
we
aim
to
cover
role
central
cells
proteinopathies
associated
with
amyloid-β
objective
identifying
new
options
for
regenerative
medicine
aimed
at
neuroprotection
neurorepair.
Язык: Английский
Efficient discovery of antibody binding pairs using a photobleaching strategy for bead encoding
Lab on a Chip,
Год журнала:
2024,
Номер
24(17), С. 4060 - 4072
Опубликована: Янв. 1, 2024
Dye-encoded
bead-based
assays
are
widely
used
for
diagnostics.
Multiple
bead
populations
required
multiplexing
and
can
be
produced
using
different
dye
colors,
labeling
levels,
or
combinations
of
ratios.
Ready-to-use
multiplex
restrict
users
to
specific
targets,
costly,
require
specialized
instrumentation.
In-house
methods
produce
few
plexes
many
fine-tuning
steps.
To
expand
encoding
strategies,
we
present
a
simple,
safe,
cost-effective
bench-top
system
generating
photobleaching.
By
photobleaching
commercially
available
dye-encoded
magnetic
beads
durations,
three
times
as
differentiable
on
flow
cytometry
from
single
color.
Our
uses
high-power
LED
module
connected
light
concentrator
heat
sink.
The
photobleached
in
solution
homogeneously
by
constant
mixing.
We
demonstrate
this
method
utilized
cross-testing
antibodies,
which
is
the
first
step
developing
immunoassays.
assay
multiple
encoded
conjugated
with
capture
antibodies
test
binding
pairs
simultaneously.
further
number
that
tested
at
once,
several
were
same
bead,
forming
pooled
assay.
predicts
performance
antibody
ultrasensitive
Simoa
assays,
narrowing
cross-tested
need
least
two-thirds
and,
therefore,
providing
rapid
alternative
an
initial
pair
screening.
other
applications,
such
multiplexing,
particles
solution.
Язык: Английский
Oligodendrocytes, the Forgotten Target of Gene Therapy
Cells,
Год журнала:
2024,
Номер
13(23), С. 1973 - 1973
Опубликована: Ноя. 28, 2024
If
the
billions
of
oligodendrocytes
(OLs)
populating
central
nervous
system
(CNS)
patients
could
express
their
feelings,
they
would
undoubtedly
tell
gene
therapists
about
frustration
with
other
neural
cell
populations,
neurons,
microglia,
or
astrocytes,
which
have
been
favorite
targets
transfer
experiments.
This
review
questions
why
OLs
left
out
most
therapy
attempts.
The
first
explanation
is
that
pathogenic
role
still
discussed
in
CNS
diseases.
Another
reason
so-called
ubiquitous
CAG,
CBA,
CBh,
CMV
promoters—widely
used
studies—are
unable
poorly
able
to
activate
transcription
episomal
transgene
copies
brought
by
adeno-associated
virus
(AAV)
vectors
OLs.
Accordingly,
expression
has
either
not
found
evaluated
studies
rodents
non-human
primates.
aims
current
are
give
rightful
place
among
cells
future
target
and
encourage
researchers
test
effect
OL
transduction
various
Язык: Английский