A novel approach for phyto-synthesis of silver nanoparticles using floral extract of Punica Granatum for potent anti-cancerous and antibacterial capabilities DOI Creative Commons
Sumit Shrivastava, Asita Kulshreshtha, Rajesh K. Gangwar

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 5, 2024

Abstract Synthesis of safest and non-toxic nanoparticles for biomedical applications in various fields science & Technology remained a vast challenge researchers. This work aims to create, analyze, examine the antibacterial effects silver that are synthesized utilizing floral extract Punica Granatum as both stabilizing reducing agent. Silver nitrate (AgNO3) solution was reduced using flower which led synthesis stable (PG-AgNPs) solution. The PG-AgNPs were examined characterized UV-Vis, FT-IR, FE-SEM, XRD, EDX methodologies. Besides this anti-bacterial anti-cancerous property also studied. results FE-SEM analysis revealed majority phytosynthesized had spherical shape evenly dispersed with diameter nearly 27.33 nm. relative presence different elements, biomolecules, capping agents. Additionally, synthesised anti-cancer potential, an IC50 ~ 13 µg. E. coli S. aureus tested nanoparticle antimicrobial efficacy. Phytosynthesized against Escherichia Staphylococcus very effective. A new chemotherapeutic medication or innovative supplement treat forms human cancer may be developed after comprehensive clinical trial containing aqueous extract.

Язык: Английский

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives DOI
Jiyuan Liu, Fan Yang, Jinqu Hu

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(5)

Опубликована: Май 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Язык: Английский

Процитировано

11
Recent Treatment Strategies and Molecular Pathways in Resistance Mechanisms of Antiangiogenic Therapies in Glioblastoma DOI Open Access
Md. Ataur Rahman,

Meser M. Ali

Cancers, Год журнала: 2024, Номер 16(17), С. 2975 - 2975

Опубликована: Авг. 27, 2024

Malignant gliomas present great difficulties in treatment, with little change over the past 30 years median survival time of 15 months. Current treatment options include surgery, radiotherapy (RT), and chemotherapy. New therapies aimed at suppressing formation new vasculature (antiangiogenic treatments) or destroying formed tumor (vascular disrupting agents) show promise. This study summarizes existing knowledge regarding processes by which glioblastoma (GBM) tumors acquire resistance to antiangiogenic treatments. The discussion encompasses activation redundant proangiogenic pathways, heightened cell invasion metastasis, induced hypoxia, creation vascular mimicry channels, regulation immune microenvironment. Subsequently, we explore potential strategies overcome this resistance, such as combining other methods, personalizing treatments for each patient, focusing on therapeutic targets, incorporating immunotherapy, utilizing drug delivery systems based nanoparticles. Additionally, would like discuss limitations methods future directions enhance beneficial effects patients GBM. Therefore, review aims research outcome GBM provide a more promising opportunity thoroughly exploring mechanisms investigating novel strategies.

Язык: Английский

Процитировано

9
Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery DOI
Mingzhu Xie, Jing Zhao, Xikang Feng

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140934 - 140934

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

1
Study on the mechanism of KIF18B affecting the malignant progression of glioblastoma cells DOI Creative Commons

Xiangyue Su,

Liji Huang,

Wei Ma

и другие.

Frontiers in Genetics, Год журнала: 2025, Номер 16

Опубликована: Март 5, 2025

Member of the driver protein family 18B (KIF18B) is a potential prognostic marker and highly expressed in variety cancers. However, its function glioblastoma (GBM) remains unclear. The expression data KIF18B were obtained by accessing TCGA, CGGA GEPIA databases, verified Western blot assay immunohistochemistry. Glioma RNA sequencing clinical information downloaded from TCGA Kaplan-plotter survival analysis Multivariable COX regression performed to plot ROC curves at 1, 3 5 years cBioPortal MethSurv used carefully examine value methylation. CBioPortal database UALCAN obtain co-expressed genes for GO KEGG enrichment analysis, gene set (GSEA) software was explore signaling pathway regulation GBM. Finally, correlation between GBM infiltration studied using TIMER dataset. various cancers including GBM, positively correlated with glioma grade negatively prognosis. curve showed that one independent risk factors methylation expression, overall rate patients hypomethylation lower than hypermethylation. A total 124 selected database. mainly involved malignant progression through P53 other pathways. GSEA high group enriched E2F, G2M results immunoassay immune tumor microenvironment. key factor affecting prognosis patients, targeting may provide new therapeutic method patients.

Язык: Английский

Процитировано

0
Intellectual Property Rights in Neuroprotective Biomaterials DOI
Chandrabhan Prajapati, Prabhash Nath Tripathi,

Saloni Sood

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities DOI Open Access
Md. Ataur Rahman, Maroua Jalouli,

Mahesh Kumar Yadab

и другие.

Cancers, Год журнала: 2025, Номер 17(4), С. 701 - 701

Опубликована: Фев. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Язык: Английский

Процитировано

0
Engineered nanoparticles as a promising drug delivery system for glioblastoma multiforme treatment DOI

Seyede Nazanin Zarneshan,

Faranak Aghaz

Therapeutic Delivery, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Март 25, 2025

Brain cancer has become an emerging medical disorder that poses a threat to human life due the uncontrolled growth of cells and their gradual spread other organs. The most aggressive life-threatening several types is GBM. Treating GBM difficult considering drugs are not exposed at brain's site action because BBTB BBB. Only few cytotoxic presently used treat GBM, including temozolomide, paclitaxel, doxorubicin, only temozolomide enough BBB penetration. In this context, engineered nanoparticles transport chemotherapeutic medications reduce notable peripheral toxicity on normal cells; for necessary drug dosages. They investigated as carriers address problem resistance linked traditional chemotherapy treatments. Many nanostructures, such polymeric, lipid-based, inorganic nanoparticles, have been developed drug-delivery methods in recent decades. To be therapeutically successful therapy, ENP formulations must diffuse through efficiently deliver target cells. Various coatings surface modifications nanostructures can tailored with different targeting moieties facilitate uptake by malignant while safeguarding healthy tissues from damage.

Язык: Английский

Процитировано

0
Combined Theoretical and Experimental Investigations: Design, Synthesis, Characterization, and In Vitro Cytotoxic Activity Assessment of a Complex of a Novel Ureacellobiose Drug Carrier with the Anticancer Drug Carmustine DOI Creative Commons
Marta Hoelm, Stanisław Porwański, Paweł Jóźwiak

и другие.

Molecules, Год журнала: 2024, Номер 29(14), С. 3359 - 3359

Опубликована: Июль 17, 2024

Drug delivery systems (DDSs) are used to transport drugs which characterized by some pharmaceutical problems the specific target site, enhancing therapeutic efficacy and reducing off-target accumulation in body. In this work, one of recently synthesized molecules, 1,10-

Язык: Английский

Процитировано

2
A comparative study of PEO-PBO content on the targeting and anti-glioma activity of annonaceous acetogenins-loaded nanomicelles DOI
Hui Ao, Yao Fu, Xiangtao Wang

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 244, С. 114176 - 114176

Опубликована: Авг. 30, 2024

Язык: Английский

Процитировано

1
Advancements in Microfluidic Platforms for Glioblastoma Research DOI Creative Commons

Rachana Raman,

V.K. Prabhu, Praveen Kumar

и другие.

Chemistry, Год журнала: 2024, Номер 6(5), С. 1039 - 1062

Опубликована: Сен. 15, 2024

Glioblastoma (GBM) is a malignant cancer affecting the brain. As per WHO classifications, it grade IV glioma and characterized by heterogenous histopathology, high recurrence rates, median age of diagnosis. Most individuals diagnosed with GBM are aged between 50 64 years, prognosis often poor. Untreated patients have survival 3 months, while treatments Temozolomide (TMZ) radiotherapy can improve to 10–14 months. Tumor common, owing inefficiency surgical resection in removing microscopic tumor formations A crucial component GBM-related research understanding microenvironment (TME) its characteristics. The various cellular interactions TME contribute higher occurrence malignancy, resistance treatments, difficulty preventative care. Incomplete pictures been obtained 2D cultures, which fail incorporate ECM other components. Identifying hallmarks developing ex vivo vitro models help study patient-specific symptoms, assess challenges, develop courses treatment timely manner more efficient than current methods. Microfluidic models, 3D cultures co-culture channel patterns, capable stimulating conditions accurately provide better responses therapeutics as would be seen patient. This facilitates refined potential delivery systems, mechanisms, metastatic pathways. review collates information on application such microfluidics-based systems analyze highlights use improving patient care options.

Язык: Английский

Процитировано

0