Quercetin alleviates chronic unpredictable mild stress‐induced depression‐like behavior by inhibiting NMDAR1 with α2δ‐1 in rats
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(4)
Опубликована: Апрель 1, 2024
Abstract
Background
Depression
is
a
serious
mental
disorder
and
the
most
prevalent
cause
of
disability
suicide
worldwide.
Chronic
unpredictable
mild
stress
(CUMS)
can
lead
to
significant
acceleration
depression
development.
Quercetin
(Que)
flavonoid
compound
with
wide
range
pharmacological
effects.
Recent
studies
have
shown
that
quercetin
improve
CUMS‐induced
depression‐like
behavior,
but
mechanism
its
improvement
still
unclear.
α2δ‐1
regulatory
subunit
voltage‐gated
calcium
channel,
which
interact
N‐methyl‐D‐aspartate
receptor
(NMDAR)
form
complex.
Objective
In
this
study,
we
found
Que
could
inhibit
increase
NMDAR
expression
in
rat
hypothalamus
induced
by
CUMS.
pain,
chronic
hypertension
other
interacts
complex,
subsequently
affects
level
NMDAR.
Consequently,
present
study
aimed
investigate
antidepressant
effect
vivo
vitro
explore
action
terms
interaction
between
Methods
Rats
were
randomly
exposed
two
stressors
every
day
for
4
weeks
establish
CUMS
model,
then
sucrose
preference
test
(SPT),
forced
swimming
(FST),
tail
suspension
(TST),
open
field
(OFT)
performed
detect
behavior
rats,
so
as
evaluate
whether
model
was
successfully
established
on
rats.
Experimental
techniques
such
serum
enzyme‐linked
immunosorbent
assay
(ELISA),
immunofluorescence,
Western
blot,
co‐immunoprecipitation,
well
experiments,
used
mechanisms
exerts
Results
Behavioral
ELISA
results
showed
produce
reduction
excitability
hypothalamic–pituitary–adrenal
(HPA)
axis
rats
improvements
their
depressive
behavior.
co‐immunoprecipitation
experiments
produced
decrease
NMDAR1
levels
interfered
binding.
addition,
neural
regulation
PC12
cells
knocked
out
gene
further
verified.
Cellular
demonstrated
led
reversal
up‐regulation
corticosterone‐injured
cells,
while
had
no
effects
knockout.
Conclusions
has
good
significantly
caused
It
inhibiting
α2δ‐1,
interfering
NMDAR,
reducing
HPA
axis.
Язык: Английский
Ferroptosis, pathogenesis and therapy in AS co-depression disease
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 24, 2025
Atherosclerosis
(AS)-related
cardiovascular
disease
and
depression
are
often
comorbid,
with
patients
facing
an
increased
risk
of
depression,
which
worsens
AS.
Both
diseases
characterized
by
oxidative
stress
lipid
metabolism
disorders.
Ferroptosis,
a
form
cell
death
iron
overload
harmful
peroxide
accumulation,
is
found
in
various
diseases,
including
AS
depression.
Consistent
the
deposition
peroxidation
(LPO)
that
characterize
ferroptosis
mechanism,
disturbances
also
crucial
pathogenic
mechanisms
The
comorbid
complex,
posing
challenges
for
clinical
treatment.
Chinese
herbs
hold
significant
potential
owing
to
their
multi-target
pharmacological
effects.
Therefore,
this
review
aims
investigate
overload,
LPO,
across
types,
shared
pathogenesis
ferroptosis,
research
on
herbal
medicine
targeting
treatment
anti-AS
co-depression.
This
provides
comprehensive
understanding
co-depression
from
perspective
ferroptosis.
Язык: Английский
Therapeutic Targets and Molecular Mechanisms of Calycosin in the Treatment of Depression: Insights From Chronic Mild Stress Animal Models
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Background
Depression
is
a
complex
psychiatric
disorder
with
limited
therapeutic
options
and
various
side
effects.
Calycosin,
bioactive
compound
derived
from
Astragalus
membranaceus
,
possesses
multiple
pharmacological
properties.
This
study
aimed
to
investigate
the
antidepressant
effects
of
calycosin
in
chronic
mild
stress
(CMS)
animal
models
depression
elucidate
its
underlying
mechanisms.
Methods
The
were
assessed
vivo
using
CMS
depression,
including
grooming
frequency
test,
sucrose
intake
tail
suspension
open
field
test.
Neurogenic
evaluated
by
measuring
levels
BDNF,
GDNF,
NGF
isolated
hippocampus
tissues.
hepatoprotective
liver
enzyme
levels.
molecular
mechanisms
calycosin's
explored
vitro
PC12
cells.
Results
Calycosin
exhibited
potent
antidepressant‐like
activities
depression.
Treatment
significantly
alleviated
depressive
symptoms
improved
neurogenic
Additionally,
displayed
modulating
enzymes
vitro.
are
mediated
stimulation
TrkB–MEK–Erk1/2–CREB
signaling
pathway.
Conclusion
In
conclusion,
shows
promise
as
novel
agent
for
due
diverse
Further
studies
warranted
exact
targets
assess
efficacy
safety
clinical
settings.
Язык: Английский
Association between triglyceride glucose-body mass index and depression among US adults: A cross-sectional study
Public Health,
Год журнала:
2024,
Номер
237, С. 410 - 417
Опубликована: Ноя. 11, 2024
Язык: Английский
Ghrelin Inhibits Inflammasomes Activation in Astrocytes, Alleviates Pyroptosis, and Prevents Lipopolysaccharide-induced Depression-like Behavior in Mice
Inflammation,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 19, 2024
Depression
is
the
leading
cause
of
disability
worldwide
and
places
a
significant
burden
on
society.
Neuroinflammation
closely
associated
with
pathophysiology
depression.
Increasing
evidence
suggests
that
astrocytes,
as
most
abundant
glial
cells
in
brain,
are
involved
occurrence
development
depression
due
to
morphological
abnormalities
dysfunction.
Astrocytes
express
NOD-like
receptor
protein
2
(NLRP2)
NLRP3
inflammasomes,
activation
inflammasomes
induces
pyroptosis.
Ghrelin,
gastrointestinal
peptide,
plays
vital
role
regulating
inflammation
alleviating
stress.
Therefore,
we
proposed
hypothesis
ghrelin
inhibits
reduces
pyroptosis,
consequently
prevents
We
used
lipopolysaccharide
(LPS)-induced
mouse
model
cultured
primary
astrocytes
vitro
explore
mechanism
antidepressant
effect
ghrelin.
Our
results
showed
effectively
inhibited
acute
inflammatory
responses
damage
hippocampus
prefrontal
cortex.
The
NLRP2
induced
by
LPS
was
significantly
Pretreatment
suppressed
LPS-induced
upregulation
pyroptosis-related
proteins
mRNA.
Ghrelin
alleviated
cell
membrane
pore
formation
swelling,
ultimately
improved
depression-like
behavior.
In
vitro,
prevented
mRNA
expression
initiation
assembly
NLRP3.
exhibits
effects,
suggesting
novel
strategy
for
treating
This
groundbreaking
study
reveals
new
avenues
targeting
potential
therapeutic
interventions
alleviate
Язык: Английский