Astragalin improves cognitive disorder in Alzheimer's disease: Based on network pharmacology and molecular docking simulation
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(8)
Опубликована: Авг. 1, 2024
We
investigate
the
mechanism
of
action
astragalin
(AST)
in
treatment
Alzheimer's
disease
(AD).
Network
pharmacology
was
conducted
to
analyze
relationships
among
AST,
AD,
and
neuroinflammation,
The
APP/PS1
transgenic
mice
with
AD
were
used
experiments;
be
specific,
influence
AST
on
behavior
analyzed
by
Morris
water
maze
eight-arm
radial
tests,
tissue
inflammatory
factor
levels
detected
ELISA,
pathological
changes
H&E
immunohistochemical
staining.
Analysis
results
network
suggested
that
exerted
multi-target
effect
neuroinflammation
AD.
Through
molecular
docking
dynamics
analyses,
COX2
might
target
AST.
Moreover,
animal
experimental
demonstrated
improved
mice,
enhanced
motor
memory
abilities,
meanwhile,
it
suppressed
expression
factors
tissues
activation
microglial
cells.
this
study
discovers
can
suppress
cell
via
improve
Язык: Английский
Shrimp peptide QMDDQ improves scopolamine-induced memory impairments by activating the Notch1 signaling pathway
Peng-Fei Yan,
Junchao Wang,
Xiyu Zhao
и другие.
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106041 - 106041
Опубликована: Фев. 1, 2025
Язык: Английский
Astragalin inhibits the proliferation of high-risk HPV-positive cervical epithelial cells and attenuates malignant cervical lesions
Cytotechnology,
Год журнала:
2025,
Номер
77(3)
Опубликована: Март 19, 2025
Язык: Английский
Investigating the Effect and Mechanism of 3-Methyladenine Against Diabetic Encephalopathy by Network Pharmacology, Molecular Docking, and Experimental Validation
Pharmaceuticals,
Год журнала:
2025,
Номер
18(5), С. 605 - 605
Опубликована: Апрель 22, 2025
Background/Objectives:
Diabetic
encephalopathy
(DE),
a
severe
neurological
complication
of
diabetes
mellitus
(DM),
is
characterized
by
cognitive
dysfunction.
3-Methyladenine
(3-MA),
methylated
adenine
derivative,
acts
as
biomarker
for
DNA
methylation
and
exhibits
hypoglycemic
neuroprotective
properties.
However,
the
pharmacological
mechanisms
underlying
3-MA’s
therapeutic
effects
on
diabetic
microvascular
complications
remain
incompletely
understood,
owing
to
intricate
multifactorial
pathogenesis
DE.
Methods:
This
study
employed
network
pharmacology
molecular
docking
techniques
predict
potential
targets
signaling
pathways
3-MA
against
DE,
with
subsequent
validation
through
animal
experiments
elucidate
in
DE
treatment.
Results:
Network
analysis
identified
two
key
modulation:
AKT
GSK3β.
Molecular
confirmed
strong
binding
affinity
between
AKT/GSK3β.
In
experiments,
significantly
reduced
blood
glucose
levels
mice,
ameliorated
learning
memory
deficits,
preserved
hippocampal
neuronal
integrity.
Furthermore,
we
found
that
inhibited
apoptosis
regulating
expression
Bax
BCL-2.
Notably,
also
downregulated
amyloid
precursor
protein
(APP)
Tau
while
enhancing
phosphorylated
GSK-3β.
Conclusions:
Our
findings
may
contribute
elucidating
microangiopathy
provide
activation
AKT/GSK-3β
pathway.
Язык: Английский
Phytochemicals from Passiflora coriacea Juss. Have Anti-Inflammatory and Neuroprotective Effects in Mouse Models
Pharmaceuticals,
Год журнала:
2024,
Номер
17(11), С. 1534 - 1534
Опубликована: Ноя. 15, 2024
Neuroinflammatory
diseases
trigger
an
inflammatory
response
and
a
state
of
oxidative
stress.
Язык: Английский