Mitochondrial DNA leakage: underlying mechanisms and therapeutic implications in neurological disorders
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Фев. 7, 2025
Mitochondrial
dysfunction
is
a
pivotal
instigator
of
neuroinflammation,
with
mitochondrial
DNA
(mtDNA)
leakage
as
critical
intermediary.
This
review
delineates
the
intricate
pathways
leading
to
mtDNA
release,
which
include
membrane
permeabilization,
vesicular
trafficking,
disruption
homeostatic
regulation,
and
abnormalities
in
dynamics.
The
escaped
activates
cytosolic
sensors,
especially
cyclic
gmp-amp
synthase
(cGAS)
signalling
inflammasome,
initiating
neuroinflammatory
cascades
via
pathways,
exacerbating
spectrum
neurological
pathologies.
therapeutic
promise
targeting
discussed
detail,
underscoring
necessity
for
multifaceted
strategy
that
encompasses
preservation
homeostasis,
prevention
leakage,
reestablishment
dynamics,
inhibition
activation
sensors.
Advancing
our
understanding
complex
interplay
between
neuroinflammation
imperative
developing
precision
interventions
disorders.
Язык: Английский
cGAS-STING targeting offers novel therapeutic opportunities in neurological diseases
Ageing Research Reviews,
Год журнала:
2025,
Номер
105, С. 102691 - 102691
Опубликована: Фев. 13, 2025
Язык: Английский
Novel Insights into Neuroinflammatory Mechanisms in Traumatic Brain Injury: Focus on Pattern Recognition Receptors as Therapeutic Targets
Cytokine & Growth Factor Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
CD300LF+ microglia impede the neuroinflammation following traumatic brain injury by inhibiting STING pathway
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(7)
Опубликована: Июль 1, 2024
The
diversity
in
microglial
phenotypes
and
functions
following
traumatic
brain
injury
(TBI)
is
poorly
characterized.
aim
of
this
study
was
to
explore
precise
targets
for
improving
the
prognosis
TBI
patients
from
a
perspective.
Язык: Английский
PARP14 inhibits microglial activation via NNT to alleviate depressive-like behaviors in mice
Brain Behavior and Immunity,
Год журнала:
2025,
Номер
126, С. 235 - 246
Опубликована: Фев. 18, 2025
Язык: Английский
The STING Signaling: A Novel Target for Central Nervous System Diseases
Cellular and Molecular Neurobiology,
Год журнала:
2025,
Номер
45(1)
Опубликована: Апрель 7, 2025
The
canonical
cyclic
GMP-AMP
(cGAMP)
synthase
(cGAS)-Stimulator
of
Interferon
Genes
(STING)
pathway
has
been
widely
recognized
as
a
crucial
mediator
inflammation
in
many
diseases,
including
tumors,
infections,
and
tissue
damage.
STING
signaling
can
also
be
activated
cGAS-
or
cGAMP-independent
manner,
although
the
specific
mechanisms
remain
unclear.
In-depth
studies
on
structural
molecular
biology
have
led
to
development
therapeutic
strategies
involving
modulators
their
targeted
delivery.
These
may
effectively
penetrate
blood-brain
barrier
(BBB)
target
multiple
central
nervous
system
(CNS)
diseases
humans.
In
this
review,
we
outline
both
non-canonical
pathways
activation
describe
general
associations
between
activity
CNS
diseases.
Finally,
discuss
prospects
for
delivery
clinical
application
agonists
inhibitors,
highlighting
novel
Язык: Английский