Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review
The Journal of Prevention of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown, С. 100130 - 100130
Опубликована: Март 1, 2025
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
characterised
by
amyloid-β
(Aβ),
tau
hyperphosphorylation
and
neurodegeneration.
Blood-based
biomarkers
are
emerging
as
minimally
invasive
tool
for
detection
monitoring.
This
review
depicts
the
relationships
between
modifiable
lifestyle
factors
(nutrition,
physical
activity
(PA),
sleep,
alcohol
consumption,
smoking,
social
isolation)
plasma
of
AD:
Aβ42,
Aβ40,
Aβ42/40,
phosphorylated
tau,
total
neurofilament
light
chain
(NfL)
glial
fibrillary
acidic
protein.
Limited
evidence
suggests
that
better
nutrition
associated
with
favourable
AD
biomarker
profiles
PA
less
NfL
Aβ,
whilst
poor
sleep
elevated
Aβ.
However,
lack
data
inconsistent
findings
highlight
need
further
investigation
to
substantiate
or
refute
these
trends.
Moreover,
future
research
should
include
analysis
on
according
gender,
metabolic
health
APOE
status.
Considering
growing
emphasis
preventing
delaying
dementia
onset
justified.
Язык: Английский
Physical activity in Alzheimer’s disease prevention: Sex differences and the roles of BDNF and irisin
Frontiers in Neuroendocrinology,
Год журнала:
2025,
Номер
unknown, С. 101189 - 101189
Опубликована: Апрель 1, 2025
Alzheimer's
disease
(AD)
disproportionately
affects
women,
with
postmenopausal
hormonal
changes
contributing
to
elevated
risk.
Physical
exercise
is
a
promising,
non-pharmacological
strategy
mitigate
cognitive
decline
and
AD
progression.
Brain-derived
neurotrophic
factor
(BDNF)
irisin
are
key
molecular
mediators
of
exercise-induced
brain
health
protection
against
pathology
by
promoting
synaptic
plasticity,
neurogenesis,
reducing
amyloidosis,
tau
pathology,
neuroinflammation
in
sex-specific
mechanisms.
This
review
explores
sex
gender
influences
on
outcomes
their
interaction
FNDC5/irisin
BDNF
signaling
pathways
the
context
prevention.
We
highlight
emerging
evidence
interplay
between
exercise,
sex,
neuroprotective
pathways,
emphasizing
need
for
sex-sensitive
research
designs
advance
precision
approaches
Язык: Английский
Physical function is associated with cognitive status, brain amyloid‐beta deposition, and blood biomarkers in Chinese Han population
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(8)
Опубликована: Авг. 1, 2024
Abstract
Background
The
physical
function
of
elderly
individuals
reflects
whether
they
have
had
a
history
regular
activity
over
the
long
term.
Such
indicators
been
found
to
certain
connection
with
cognitive
these
years.
However,
there
is
limited
research
that
associates
it
mechanisms
such
as
cerebral
Aβ
deposition.
We
aim
investigate
this
relationship
and
unveil
underlying
mechanisms.
Method
Physical
cognition
data
4189
participants
were
obtained
from
Chinese
preclinical
Alzheimer's
disease
study.
Participants
divided
into
six
groups
according
severity.
Among
them,
1048
underwent
positron
emission
tomography‐computed
tomography
(PET‐CT)
plasma
biomarker
test.
Grip
strength
gait
combined
score
indicating
function.
Multiple
linear
regression
models
logistic
mainly
used
conduct
analysis.
Results
There
was
significant
positive
correlation
between
(
R
=
0.48,
p
<
0.001),
independent
sex,
age,
apolipoprotein
E‐ε4
genotype,
stages
0.001).
effective
in
distinguishing
impairment
those
without
(AUC
0.835).
negatively
associated
brain
deposition
0.008)
an
intermediary
effect
0.01)
on
association
women.
This
evident
lateral
parietal,
temporal,
posterior
cingulate,
frontal,
occipital,
precuneus
regions.
neurofilament
light‐chain
(Nfl)
level
Conclusions
strongly
elderly,
partly
mediates
linkage
Plasma
Nfl
can
be
potential
target
for
exercise
intervention
Improving
will
contribute
alleviation
decline.
Язык: Английский