Myelin modulates the process of isoflurane anesthesia through the regulation of neural activity DOI Creative Commons
Xu Wang,

Rulan Yi,

Liang Xiaoling

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(8)

Опубликована: Авг. 1, 2024

Abstract Aims The mechanism underlying the reversible unconsciousness induced by general anesthetics (GA) remains unclear. Recent studies revealed critical roles of myelin and oligodendrocytes (OLs) in higher functions brain. However, it is unknown whether actively participates regulation GA. aim this study to investigate possible mechanisms consciousness alterations isoflurane anesthesia. Methods First, demyelination models for entire brain specific neural nuclei were established potential role myelination GA, as well its regional specificity. c‐Fos staining was then performed on demyelinated verify impact loss neuronal activity. Finally, activity neurons during anesthesia mice recorded optical fiber photometric calcium signal. related behavioral indicators EEG analyzed. Results A prolonged emergence time observed from mice, which suggested involvement regulating distinct LPC further clarified region‐specific myelin. effect certain nucleus consistent with that towards we found modulation possibly through Conclusions In brief, plays an essential process modification integrity Our findings enhanced comprehension function, offered a fresh perspective investigating

Язык: Английский

Myelin modulates the process of isoflurane anesthesia through the regulation of neural activity DOI Creative Commons
Xu Wang,

Rulan Yi,

Liang Xiaoling

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(8)

Опубликована: Авг. 1, 2024

Abstract Aims The mechanism underlying the reversible unconsciousness induced by general anesthetics (GA) remains unclear. Recent studies revealed critical roles of myelin and oligodendrocytes (OLs) in higher functions brain. However, it is unknown whether actively participates regulation GA. aim this study to investigate possible mechanisms consciousness alterations isoflurane anesthesia. Methods First, demyelination models for entire brain specific neural nuclei were established potential role myelination GA, as well its regional specificity. c‐Fos staining was then performed on demyelinated verify impact loss neuronal activity. Finally, activity neurons during anesthesia mice recorded optical fiber photometric calcium signal. related behavioral indicators EEG analyzed. Results A prolonged emergence time observed from mice, which suggested involvement regulating distinct LPC further clarified region‐specific myelin. effect certain nucleus consistent with that towards we found modulation possibly through Conclusions In brief, plays an essential process modification integrity Our findings enhanced comprehension function, offered a fresh perspective investigating

Язык: Английский

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