Neurobiology of Disease, Год журнала: 2025, Номер 207, С. 106852 - 106852

Опубликована: Фев. 20, 2025

Sphingolipids are a class of lipids highly expressed in brain, especially the myelin sheath white matter. In recent years, with development lipidomics, role brain sphingolipids neurological disorders have raised lots interests due to their function neuronal signal transduction and survival. Although not thoroughly investigated, some previous studies indicated that homeostasis closely linked etiology disorders. For example, disrupted level been found clinic patients disorders, such as neurodegeneration psychiatric Conversely, intervention metabolism by modulating activity related enzymes also could result pathological deficits identified Moreover, alteration catabolic pathway be partly represented cerebrospinal fluid blood tissues, which show diagnostic potential for Therefore, our review aims summarize discuss known contents bioactive sphingolipid neurodegenerative help understand mechanism underlying regulation neural provide possible directions further study. The new perspectives this promising field will open up therapeutic options

Язык: Английский