NLRP3 inflammasome in neuroinflammation and central nervous system diseases
Cellular and Molecular Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Abstract
Neuroinflammation
plays
an
important
role
in
the
pathogenesis
of
various
central
nervous
system
(CNS)
diseases.
The
NLRP3
inflammasome
is
intracellular
multiprotein
complex
composed
innate
immune
receptor
NLRP3,
adaptor
protein
ASC,
and
protease
caspase-1.
activation
can
induce
pyroptosis
release
proinflammatory
cytokines
IL-1β
IL-18,
thus
playing
a
inflammatory
responses.
Recent
studies
have
revealed
that
activated
brain
to
neuroinflammation,
leading
further
neuronal
damage
functional
impairment,
contributes
pathological
process
neurological
diseases,
such
as
multiple
sclerosis,
Parkinson’s
disease,
Alzheimer’s
stroke.
In
this
review,
we
summarize
neuroinflammation
course
CNS
diseases
discuss
potential
approaches
target
for
treatment
Язык: Английский
Remote Organ Damage Induced by Stroke: Molecular Mechanisms and Comprehensive Interventions
Antioxidants and Redox Signaling,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Significance:
Damage
after
stroke
is
not
only
limited
to
the
brain
but
also
often
occurs
in
remote
organs,
including
heart,
lung,
liver,
kidney,
digestive
tract,
and
spleen,
which
are
frequently
affected
by
complex
pathophysiological
changes.
The
organs
human
body
closely
connected,
signals
transmitted
through
various
molecular
substances
could
regulate
changes
of
organs.
Recent
Advances:
latest
studies
have
shown
that
inflammatory
response
plays
an
important
role
organ
damage
stroke,
can
aggravate
activating
oxidative
stress,
sympathetic
axis,
hypothalamic
disturbing
immunological
homeostasis.
Remote
cause
brain,
aggravating
damage.
Critical
Issues:
Therefore,
in-depth
exploration
mechanisms
adopting
corresponding
comprehensive
intervention
strategies
become
necessary
reduce
promote
protection.
Future
Directions:
strategy
involves
multifaceted
treatment
methods
such
as
inflammation
regulation,
antioxidants,
neural
stem
cell
differentiation.
It
provides
a
promising
alternative
for
recovery
patients
inspiration
future
research
treatment.
interconnected
at
level.
Only
levels
we
save
protect
greatest
extent.
Antioxid.
Redox
Signal.
00,
000-000.
Язык: Английский
BUN‐to‐ALB ratio as an effective predictor of 30 day mortality in ADHF patients in eastern China
ESC Heart Failure,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
The
blood
urea
nitrogen-to-albumin
ratio
(BAR)
is
considered
a
potential
indicator
for
assessing
the
poor
prognosis
of
heart
failure
(HF).
However,
its
prognostic
value
Chinese
patients
with
acute
decompensated
HF
(ADHF)
remains
unclear.
This
study
included
ADHF
who
met
criteria
and
were
admitted
to
Jiangxi
Provincial
People's
Hospital
from
2019
2022.
We
first
employed
univariate
multivariate
Cox
regression
models
determine
role
BAR
in
evaluating
short-term
patients.
Subsequently,
we
used
restricted
cubic
spline
explore
nonlinear
relationship
threshold
between
prognosis.
Receiver
operating
characteristic
(ROC)
curve
analysis
was
performed
calculate
predictive
accuracy
30
day
mortality
identify
relevant
points.
A
total
1421
analysis,
population
divided
into
two
groups
based
on
optimal
(0.33)
determined
by
ROC
analysis.
During
median
follow-up
period,
rates
high-BAR
low-BAR
12.46%
1.26%,
respectively.
Multivariable
indicated
that
high
associated
an
increased
risk
[hazard
(HR):
3.25,
95%
confidence
interval
(CI):
1.28-8.30],
particularly
among
those
concomitant
cerebral
infarction
(HR:
19.12,
CI:
2.67-136.67).
five
sensitivity
analyses
completed
consistent
results
main
Furthermore,
revealed
association
(P
nonlinearity:
<0.001),
effect
observed
when
0.3
0.5.
efficiency
~84%,
area
under
(AUC)
0.84.
found
can
serve
as
effective
predictor
clinical
data
population,
calculated
at
0.33.
Язык: Английский
Lipocalin 2 mediates kidney function abnormalities induced by ischemic stroke in mice: Involvement of neural pathways
Experimental Neurology,
Год журнала:
2025,
Номер
389, С. 115267 - 115267
Опубликована: Апрель 17, 2025
Язык: Английский
Brain–Periphery Axes: The Potential Role of Extracellular Vesicles-Delivered miRNAs
Biology,
Год журнала:
2024,
Номер
13(12), С. 1056 - 1056
Опубликована: Дек. 16, 2024
Bidirectional
communication
between
the
central
nervous
system
(CNS)
and
peripheral
organs
tissue
has
been
widely
documented
in
physiological
pathological
conditions.
This
relies
on
bilateral
transmission
of
signaling
molecules
substances
that
circulate
throughout
body
reach
their
target
site(s)
via
blood
other
biological
fluids
(e.g.,
cerebrospinal
fluid,
lymph).
One
mechanisms
by
which
these
molecular
messengers
are
exchanged
is
through
secretion
extracellular
vesicles
(EVs).
EVs
known
to
mediate
cell-to-cell
delivering
molecules,
including
nucleic
acids,
proteins,
lipids,
various
bioactive
regulators.
Moreover,
can
cross
blood–brain
barrier
(BBB),
enabling
direct
periphery
brain.
In
particular,
delivery
microRNAs
(miRNAs)
modulate
expression
profiles
recipient
cells,
thereby
influencing
functions.
review
synthesizes
current
findings
about
brain–periphery
cross-talk
mediated
EVs-delivered
miRNAs.
Although
this
mechanism
definitively
shown
a
few
cases,
much
evidence
indirectly
indicates
it
could
brain–peripherical
organs/tissue
communication,
especially
Therefore,
understanding
process
provide
valuable
insights
for
treatment
management
neurological
systemic
diseases.
Язык: Английский