Biomedicines,
Год журнала:
2023,
Номер
11(9), С. 2467 - 2467
Опубликована: Сен. 6, 2023
Low
back
pain
is
the
leading
cause
of
disability
worldwide.
Intervertebral
disc
degeneration
(IDD)
primary
clinical
risk
factor
for
low
and
pathological
herniation,
spinal
stenosis,
deformity.
A
possible
approach
to
improve
practice
IDD-related
diseases
incorporate
biomarkers
in
diagnosis,
therapeutic
intervention,
prognosis
prediction.
IDD
pathology
still
unclear.
Regarding
molecular
mechanisms,
cellular
signaling
pathways
constitute
a
complex
network
that
coordinate
cell
survival,
proliferation,
differentiation,
metabolism.
Recently,
stem
cells
have
shown
great
potential
applications
IDD.
In
this
review,
roles
multiple
related
treatment
are
summarized
described.
This
review
seeks
investigate
mechanisms
effects
identify
new
treatments
disorders.
Abstract
Circadian
rhythm
is
ubiquitous
in
nature.
clock
genes
such
as
Bmal1
and
Clock
form
a
multi-level
transcription-translation
feedback
network,
regulate
variety
of
physiological
pathological
processes,
including
bone
cartilage
metabolism.
Deletion
the
core
gene
leads
to
alterations,
while
phenotypes
are
not
consistent.
Studies
have
shown
that
multiple
signaling
pathways
involved
process
regulating
metabolism,
but
exact
regulatory
mechanisms
remain
unclear.
This
paper
reviews
by
which
regulates
bone/cartilage
upstream
factors
control
,
current
knockout
mouse
models
for
research.
We
hope
provide
new
insights
prevention
treatment
diseases
related
circadian
rhythms.
Aging and Disease,
Год журнала:
2023,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2023
With
the
aging
of
global
population,
incidence
musculoskeletal
diseases
has
been
increasing,
seriously
affecting
people's
health.
As
people
age,
microenvironment
within
skeleton
favors
bone
resorption
and
inhibits
formation,
accompanied
by
marrow
fat
accumulation
multiple
cellular
senescence.
Specifically,
skeletal
stem/stromal
cells
(SSCs)
during
tend
to
undergo
adipogenesis
rather
than
osteogenesis.
Meanwhile,
osteoblasts,
as
well
osteocytes,
showed
increased
apoptosis,
decreased
quantity,
functional
limitations
including
impaired
mechanical
sensing,
intercellular
modulation,
exosome
secretion.
Also,
function
macrophage-lineage
(including
osteoclasts
preosteoclasts)
was
significantly
enhanced,
vascularization
innervation.
In
this
study,
we
systematically
reviewed
effect
on
their
intracellular
structure
variations,
vascular
structures,
innervation,
distribution,
lymphatic
system)
caused
aging,
mechanisms
osteoimmune
regulation
environment
in
state,
causal
relationship
with
addition
potential
therapeutic
strategy.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Дек. 30, 2022
Abstract
Periodontal
tissue
is
a
highly
dynamic
and
frequently
stimulated
area
where
homeostasis
easily
destroyed,
leading
to
proinflammatory
periodontal
diseases.
Bacteria–bacteria
cell–bacteria
interactions
play
pivotal
roles
in
disease
progression.
Several
reviews
have
comprehensively
summarized
the
of
bacteria
stem
cells
homeostasis.
However,
they
did
not
describe
extracellular
vesicles
(EVs)
from
cells.
As
communication
mediators
evolutionarily
conserved
eukaryotic
cells,
EVs
secreted
by
or
can
mediate
between
their
hosts,
thereby
offering
great
promise
for
maintenance
This
review
offers
an
overview
EV
biogenesis,
effects
on
homeostasis,
recent
advances
EV-based
regenerative
strategies.
Specifically,
we
document
pathogenic
bacteria-derived
(BEVs)
dyshomeostasis,
focusing
plaque
biofilm
formation,
immune
evasion,
inflammatory
pathway
activation
destruction.
Moreover,
summarize
advancements
cell-derived
(CEVs)
emphasizing
multifunctional
biological
CEVs
regeneration.
Finally,
discuss
future
challenges
practical
perspectives
clinical
translation
therapies
periodontitis.
Graphical
FEBS Journal,
Год журнала:
2022,
Номер
290(12), С. 3059 - 3075
Опубликована: Март 19, 2022
Hedgehog
signalling
is
essential
for
development,
crucial
normal
anatomical
arrangement
and
activated
during
tissue
damage
repair.
Dysregulation
of
hedgehog
associated
with
cancer,
developmental
disorders
other
diseases
including
osteoarthritis
(OA).
The
gene
was
first
discovered
in
Drosophila
melanogaster,
the
pathway
evolutionarily
conserved
most
animals.
Although
there
are
several
ligands
different
protein
expression
patterns,
they
share
a
common
plasma
membrane
receptor,
Patched1
activation
transduced
through
G-protein-coupled
receptor-like
Smoothened
(SMO)
downstream
effectors.
Functional
assays
revealed
that
SMO
dependent
on
sterol
binding,
cholesterol
observed
bound
to
crystallography
experiments.
In
vertebrates,
coordinates
endochondral
ossification
balances
osteoblast
osteoclast
maintain
homeostasis.
A
recently
mutation
humans
(SMOR173C
)
predicted
alter
binding
higher
risk
hip
OA.
studies
mice
human
analysis
provide
evidence
pathologically
chondrocytes
osteoarthritic
cartilage.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 7, 2023
Osteoarthritis
is
a
chronic
degenerative
joint
disease
that
exerts
significant
impacts
on
personal
life
quality,
and
cartilage
tissue
engineering
practical
treatment
in
clinical.
Various
growth
factors
are
involved
regeneration
play
important
roles
therein,
which
the
focus
of
current
repair
strategy.
To
compensate
for
purification
difficulty,
high
cost,
poor
metabolic
stability,
circulating
dilution
natural
factors,
concept
functional
motifs
(also
known
as
mimetic
peptides)
from
original
factor
was
introduced
recent
studies.
Here,
we
reviewed
selection
mechanisms,
biological
functions,
carrier
scaffolds,
modification
methods
factor-related
motifs,
evaluated
performance
engineering.
Finally,
prospects
researches
clinical
application
were
discussed.
Abstract
Bone
development
abnormalities
are
challenging
disorders
with
significant
physical
and
emotional
impacts.
These
can
stem
from
genetic
or
lifestyle
factors,
causes
presenting
ongoing
research
challenges.
This
study
investigates
the
Indian
hedgehog
(Ihh)
gene,
which
is
known
to
be
involved
in
bone
formation
issues.
We
analyzed
non-synonymous
single
nucleotide
polymorphisms
(nsSNPs)
Ihh
gene
retrieved
dbSNP
database
for
their
deleterious
nature
functional
impact
using
various
programs,
including
PolyPhen-2.0,
FATHMM,
Panther,
SIFT,
Provean,
Mutation
Assessor,
SNPS&GO.
The
stability
of
protein
structure
was
evaluated
Dynamut
I-Mutant
3.0.
Out
436
nsSNPs
analyzed,
103
mutations
were
found
destabilize
protein.
Special
attention
given
located
domain
regions
critical
function.
Native
mutant
models
predicted
SWISSMODEL,
validated
PROCHECK,
compared
RMSD
values
PyMOL.
Functional
impacts
assessed
through
docking
studies
binding
partner
PatchDock.
Significant
changes
interaction
energies
scores
observed,
suggesting
potential
effects
on
computational
indicates
that
these
may
contribute
bone-related
suggests
could
a
drug
target
further
investigation
improved
disease
management.
