Cell Proliferation, Год журнала: 2024, Номер unknown
Опубликована: Дек. 30, 2024
Overview of the functions and applications myokines MyoEVs.
Язык: Английский
npj Vaccines, Год журнала: 2025, Номер 10(1)
Опубликована: Янв. 3, 2025
Язык: Английский
Процитировано
1
Cell Proliferation, Год журнала: 2024, Номер 57(7)
Опубликована: Март 20, 2024
Abstract Neoantigen delivery using extracellular vesicles (EVs) has gained extensive interest in recent years. EVs derived from tumour cells or immune have been used to deliver antigens antitumor stimulation signals. However, potential DNA contamination the host cell and cost of large‐scale EV production hinder their therapeutic applications clinical settings. Here, we develop an antigen platform for cancer vaccines red blood cell‐derived (RBCEVs) targeting splenic DEC‐205 + dendritic (DCs) boost effect. By loading ovalbumin (OVA) protein onto RBCEVs delivering DCs, were able stimulate present antigenic OVA peptide major histocompatibility complex (MHC) class I, subsequently priming activated antigen‐reactive T cells. Importantly, targeted engineered with anti‐DEC‐205 antibody robustly enhanced presentation DCs activation. This is potentially useful producing personalised
Язык: Английский
Процитировано
6
Molecules, Год журнала: 2024, Номер 29(13), С. 2995 - 2995
Опубликована: Июнь 24, 2024
Herein, we report a transdermal patch prepared using an ionic liquid-based solid in oil (IL-S/O) nanodispersion and pressure-sensitive adhesive (PSA) to deliver the macromolecular antigenic protein, ovalbumin (OVA). The IL-S/O PSA were first mixed at equal weight ratio, then coated onto release liner, covered with support film. To evaluate effect of PSA, three types PSAs, DURO-TAK 87-4098, 87-4287, 87-235A, used obtain corresponding patches SP-4098, SP-4287, SP-235A, respectively. characterized for surface morphology, viscoelasticity, moisture content. In vitro skin penetration vivo immunization studies performed Yucatan micropig C57BL/6NJc1 mice model, SP-4098 SP-4287 delivered 5.49-fold 5.47-fold higher amounts drug compared aqueous formulation. Although both similar amount drug, was not detached fully from liner after 30 days, indicating low stability. Mice immunized OVA-containing produced 10-fold increase anti-OVA IgG those treated These findings suggested that may be good platform delivery antigen molecules.
Язык: Английский
Процитировано
3
Journal of Controlled Release, Год журнала: 2024, Номер 375, С. 712 - 732
Опубликована: Сен. 27, 2024
Язык: Английский
Процитировано
2
Cell Proliferation, Год журнала: 2024, Номер unknown
Опубликована: Сен. 1, 2024
Abstract Inducing tertiary lymphoid structure (TLS) formation can fuel antitumor immunity. It is necessary to create mouse models containing TLS explore strategies of formation. Oncolytic herpes simplex virus‐1 (oHSV) exhibited intense effects in preclinical and clinical trials. However, the role oHSV remains be elucidated. Here, we observed presence 4MOSC1 MC38 subcutaneous tumour models. Interestingly, evoked formation, increased infiltration B cells stem‐like TCF1 + CD8 T proliferation. Mechanistically, expression TLS‐related chemokines, along with upregulated CXCL10/CXCR3 facilitate Notably, CXCL10 CXCR3 were favourable prognostic factors for cancer patients, closely related immune infiltration. Inhibiting reduced granzyme expression, impaired oHSV‐mediated Furthermore, revealed superior response survival rate when combined αPD‐1 treatment. Collectively, these findings indicate that recruits through pathway propagate warrants future immunity development.
Язык: Английский
Процитировано
1
Cell Proliferation, Год журнала: 2024, Номер unknown
Опубликована: Дек. 30, 2024
Overview of the functions and applications myokines MyoEVs.
Язык: Английский
Процитировано
0