The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging
Cell Proliferation,
Год журнала:
2024,
Номер
57(10)
Опубликована: Май 3, 2024
Abstract
The
Hippo
signalling
pathway
is
a
conserved
kinase
cascade
that
orchestrates
diverse
cellular
processes,
such
as
proliferation,
apoptosis,
lineage
commitment
and
stemness.
With
the
onset
of
society
ages,
research
on
skeletal
aging‐mechanics‐bone
homeostasis
has
exploded.
In
recent
years,
aging
mechanical
force
in
system
have
gained
groundbreaking
progress.
Under
regulation
mechanics
aging,
crucial
role
development
bone.
We
synthesize
current
knowledge
pathway,
particularly
its
downstream
effectors
yes‐associated
protein
(YAP)
transcriptional
co‐activator
with
PDZ‐binding
motif
(TAZ),
bone
homeostasis.
discuss
specification
function
different
cell
types
by
pathway.
interactions
other
pathways,
Wnt,
transforming
growth
factor
beta
nuclear
kappa‐B,
are
also
mentioned
because
their
importance
for
modulating
Furthermore,
YAP/TAZ
been
extensively
studied
mechanotransducers.
Due
to
space
limitations,
we
focus
reviewing
how
forces
influence
fate,
communications
through
dysregulated
Язык: Английский
The physiological and pathogenic roles of yes-associated protein/transcriptional co-activator with PDZ-binding motif in bone or skeletal motor system-related cells
CytoJournal,
Год журнала:
2025,
Номер
22, С. 13 - 13
Опубликована: Фев. 8, 2025
Yes-associated
protein
(YAP)
and
transcriptional
co-activator
with
PDZ-binding
motif
(TAZ)
are
the
primary
downstream
effectors
of
Hippo
signaling
pathway.
This
pathway
plays
a
crucial
role
in
regulating
organ
size,
maintaining
tissue
homeostasis,
controlling
cellular
processes
such
as
fate
determination
development.
review
provides
an
overview
current
understanding
how
regulators
YAP
TAZ
contribute
to
physiological
pathological
tissues
cells
associated
skeletal
motor
system.
The
underlying
molecular
mechanisms
mechanical
transduction
were
reviewed.
Язык: Английский
Regulation of Skeletogenic Pathways by m6A RNA Modification: A Comprehensive Review
Calcified Tissue International,
Год журнала:
2025,
Номер
116(1)
Опубликована: Апрель 3, 2025
Язык: Английский
The Hippo pathway in bone and cartilage: implications for development and disease
PeerJ,
Год журнала:
2025,
Номер
13, С. e19334 - e19334
Опубликована: Апрель 22, 2025
Bone
is
the
main
structure
of
human
body;
it
mainly
plays
a
supporting
role
and
participates
in
metabolic
processes.
The
Hippo
signaling
pathway
composed
series
protein
kinases,
including
mammalian
STE20-like
kinase
MST1/2
large
tumor
suppressor
LATS1/2,
which
are
widely
involved
pathophysiological
processes,
cell
proliferation,
differentiation,
apoptosis
death,
especially
those
related
to
biomechanical
transduction
vivo
.
However,
regulating
skeletal
system
development
evolution
bone-related
diseases
remains
poorly
understood.
can
intervene
regulate
physiological
activities
cells
such
as
osteoclasts
chondrocytes
through
its
own
or
other
pathways,
Wnt
pathway,
Notch
receptor
activator
nuclear
factor-κB
ligand
(RANKL),
thereby
affecting
occurrence
bone
diseases.
This
article
discusses
disease
provide
new
insights
into
treatment
by
targeting
pathway.
Язык: Английский
CCN Proteins as Matricellular Regulators of Bone in Aging and Disease
Current Osteoporosis Reports,
Год журнала:
2025,
Номер
23(1)
Опубликована: Май 23, 2025
This
review
explores
the
role
of
cell
communication
network
(CCN)
proteins
in
regulating
skeletal
physiology,
aging,
and
disease,
particularly
within
context
balanced
bone
remodeling.
Recent
conceptualization
paracrine
endocrine
networks
marrow
as
a
form
osteoimmunological
crosstalk
suggests
significant
for
matricellular
signaling
homeostasis.
As
multifunctional
adapters
cell-matrix
interactions,
CCNs
are
emerging
focal
point
parathyroid
hormone
(PTH)
regulation
RANKL/RANK/OPG
axis
aging.
Altered
CCN
expression
creates
permissive
environment
accelerated
postmenopausal
loss
may
contribute
to
pathogenesis
osteoporosis
other
diseases
related
modulate
fundamental
mechanisms
development,
homeostasis
repair.
During
dysregulation
negatively
affect
health
disease
progression.
result,
constitute
promising
therapeutic
targets
improving
maintaining
aging
health.
Язык: Английский
Bio-characteristics, tissue expression of miR-375 in hypothalamic-pituitary-ovarian axis and its regulation in reproduction-related diseases
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 9, 2024
Our
study
concentrated
on
the
expression
of
miRNA-375
in
hypothalamic-pituitary-gonadal
axis
female
Hu
sheep.
The
investigation
involved
cloning
precursor
sequence
miR-NA-375,
followed
by
comparison
with
database
entries
and
subsequent
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment
analyses.
In
our
approach,
we
obtained
ovaries,
thalamus,
cerebellum,
brain,
uterus,
pituitary
gland,
hypothalamus,
pineal
gland
from
fertile
but
nonpregnant
ewes.
MiRNA
extraction
kit
was
used
to
extract
miRNA
above
eight
tissues.
Real-time
fluorescent
quantitative
polymerase
chain
reaction
evaluate
role
miR-375
hy-pothalamic-pituitary-gonadal
axis.
results
were
compared
those
Anopheles
gambiae,
Apis
mellifera,
Bos
taurus,
Drosophila
melanogaster,
Danio
rerio,
Fugu
rubripes,
Gallus
gallus,
Homo
sapiens,
Monodelphis
domestica,
Macaca
mulatta,
Mus
musculus,
Pan
troglodytes,
Rattus
norvegicus,
Tetraodon
nigroviridis,
Xenopus
tropicalis
miRBase
database.
It
found
that
oar-miR-375
highly
conserved.
Notably,
significantly
higher
(p
<
0.01)
than
hypothalamus.
also
predicting
target
genes.
GO
KEGG
analyses
these
predicted
genes
revealed
is
182
biological
processes,
affects
186
cellular
components,
participates
184
molecular
functions.
terms
pathway
enrichment,
linked
nine
pathways,
including
Hippo,
Wnt,
mTOR
signaling
pathways.
This
has
validated
interaction
between
its
gene
FZD4,
which
can
be
recognized
bound
produce
effects.
These
findings
lead
inference
may
play
a
crucial
regulatory
sheep
reproduction
through
Hippo
Wnt
pathway,
laying
foundation
for
further
exploration
miR-375's
this
domain.
Язык: Английский