Tetrahedral framework nucleic acid–based small‐molecule inhibitor delivery for ecological prevention of biofilm
Cell Proliferation,
Год журнала:
2024,
Номер
57(9)
Опубликована: Май 29, 2024
Biofilm
formation
constitutes
the
primary
cause
of
various
chronic
infections,
such
as
wound
gastrointestinal
inflammation
and
dental
caries.
While
preliminary
achievement
biofilm
inhibition
is
possible,
challenge
lies
in
difficulty
eliminating
bactericidal
effects
current
drugs
that
lead
to
microbiota
imbalance.
This
study,
utilizing
vitro
vivo
models
caries,
aims
efficiently
inhibit
without
inducing
effects,
even
against
pathogenic
bacteria.
The
tetrahedral
framework
nucleic
acid
(tFNA)
was
employed
a
delivery
vector
for
small-molecule
inhibitor
(smI)
specifically
targeting
activity
glucosyltransferases
C
(GtfC).
It
observed
tFNA
loaded
smI
small-groove
binding
manner,
transferring
it
into
Streptococcus
mutans,
thereby
inhibiting
GtfC
extracellular
polymeric
substances
compromising
bacterial
survival.
Furthermore,
smI-loaded
demonstrated
reduction
severity
caries
adversely
affecting
oral
microbial
diversity
exhibited
desirable
topical
systemic
biosafety.
study
emphasizes
concept
'ecological
prevention
biofilm',
which
anticipated
advance
optimization
strategies
clinical
application
DNA
nanocarrier-based
drug
formulations.
Язык: Английский
Advancements in Engineering Tetrahedral Framework Nucleic Acids for Biomedical Innovations
Small Methods,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Tetrahedral
framework
nucleic
acids
(tFNAs)
are
renowned
for
their
controllable
self-assembly,
exceptional
programmability,
and
excellent
biocompatibility,
which
have
led
to
widespread
application
in
the
biomedical
field.
Beyond
these
features,
tFNAs
demonstrate
unique
chemical
biological
properties
including
high
cellular
uptake
efficiency,
structural
bio-stability,
tissue
permeability,
derived
from
distinctive
3D
structure.
To
date,
an
extensive
range
of
tFNA-based
nanostructures
intelligently
designed
developed
various
applications
such
as
drug
delivery,
gene
therapy,
biosensing,
engineering,
among
other
emerging
fields.
In
addition
role
delivery
systems,
also
possess
intrinsic
that
render
them
highly
effective
therapeutic
agents
treatment
complex
diseases,
arthritis,
neurodegenerative
disorders,
cardiovascular
diseases.
This
dual
functionality
significantly
enhances
utility
research,
presenting
valuable
opportunities
development
next-generation
medical
technologies
across
diverse
diagnostic
platforms.
Consequently,
this
review
comprehensively
introduces
latest
advancements
field,
with
a
focus
on
benefits
nanoplatforms,
inherent
capabilities
agents.
Furthermore,
current
limitations,
challenges,
future
perspectives
explored.
Язык: Английский