Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
ABSTRACT
In
Western
countries,
the
increase
in
consumption
of
soy‐derived
products
raises
population's
exposure
to
isoflavones.
These
molecules,
present
many
foods,
have
numerous
effects
on
body's
cells,
including
regulation
transcription
and
epigenetics,
cell
signaling,
cycle,
growth,
apoptosis,
oxidative
stress.
However,
despite
multitude
studies
conducted,
these
compounds,
it
remains
difficult
draw
definitive
conclusions
regarding
their
safety
or
dangerousness
diet.
Indeed,
some
epidemiological
highlight
health
benefits
consuming
isoflavone‐rich
notably
by
reducing
risk
certain
cancers.
several
conducted
models
show
that
molecules
can
negative
fate,
particularly
with
regard
proliferation
survival
mammary
tumor
cells.
Isoflavones
are
mainly
genistein,
daidzein,
formononetin,
biochanin
A.
belong
family
phytoestrogens,
which
capable
interacting
both
nuclear
estrogen
receptor,
ERα
ERβ,
trigger
agonistic
antagonistic
effects.
Due
estrogenic
properties,
isoflavones
suspected
promote
hormone‐dependent
cancers
such
as
breast
cancer.
This
suspicion
is
based
primarily
ability
bind
thereby
altering
signaling
pathways
control
growth.
study
results
sometimes
contradictory.
Some
suggest
may
protect
against
cancer
acting
selective
receptor
modulators,
while
others
potential
role
stimulating
review
explores
literature
isoflavones,
focusing
influence
ERα‐dependent
Acta Neuropathologica Communications,
Год журнала:
2025,
Номер
13(1)
Опубликована: Май 21, 2025
Lung
cancer
is
a
leading
cause
of
cancer-related
deaths
worldwide,
with
brain
metastasis
occurring
in
approximately
30-55%
patients,
particularly
lung
adenocarcinoma.
Due
to
the
challenges
obtaining
genuine
tumor
cells,
researchers
commonly
use
nude
mouse
models
establish
cell
lines,
though
traditional
methods
have
limitations
such
as
high
costs,
lengthy
timeframes,
and
need
for
specialized
imaging
equipment.
To
address
these
issues,
we
developed
an
improved
approach
by
performing
low
number
circulating
intracranial
injections
(500-4000
cells)
mice,
successfully
establishing
H1975-BM1,
BM2,
BM3
lines.
Through
RNA
sequencing
bioinformatics
analyses,
identified
transcriptomic
differences
among
revealing
that
H1975-BM1
cells
primarily
exhibit
stem
function
migration
characteristics,
while
H1975-BM3
display
enhanced
chemotaxis,
adhesion,
cytokine
secretion
associated
interactions.
Experimental
validation,
including
Transwell
assays,
CCK8,
adhesion
subcutaneous
implantation
further
confirmed
findings,
forming
larger
tumors
more
pronounced
cystic
cavity.
In
conclusion,
our
methodology
established
high-confidence
adenocarcinoma
elucidating
distinct
functional
characteristics
at
different
stages
progression.
Therapeutic Advances in Medical Oncology,
Год журнала:
2025,
Номер
17
Опубликована: Июнь 1, 2025
Background:
There
is
no
recognized
optimal
second-line
treatment
option
for
advanced
hormone
receptor-positive
(HR+)
breast
cancer
patients
with
CDK4/6
inhibitor
(CDK4/6i)
resistance.
Objectives:
This
work
aims
to
identify
the
by
evaluating
efficacy
of
various
options
in
CDK4/6i-pretreated
HR+
cancer.
Subgroup
analyses
aim
discuss
how
different
genetic
backgrounds
and
clinical
characteristics
influence
efficacy.
Design:
A
systematic
review
network
meta-analysis
(NMA)
was
designed.
Data
sources
methods:
comprehensive
search
conducted
Medline,
Embase,
Cochrane
Library
randomized
controlled
trials
(RCTs).
The
primary
outcome
progression-free
survival
(PFS),
subgroup
analysis
based
on
visceral
metastasis
ESR1
mutations.
Secondary
outcomes
were
overall
(OS),
response
rate
(ORR),
benefit
(CBR).
Bayesian
NMA
using
GeMTC
R,
hazard
ratios
95%
confidence
intervals
as
effect
measures.
Results:
Our
included
19
involving
13
regimens
(
n
=
6621),
14
studies
3876)
reporting
results
patients.
Results
showed
that
combination
CDK4/6i
fulvestrant
(Ful)
most
effective
regimen
improving
PFS
Further
mutations
consistently
confirmed
this
finding.
For
OS,
Bcl-2
(Bcl-2i)
Ful
favorable.
In
terms
ORR
CBR,
selective
estrogen
receptor
degraders
(SERD)
+
ET
beneficial,
respectively,
significant
differences
among
direct
comparisons.
Conclusion:
reveals
cancer,
particularly
metastases
or
addition,
Bcl-2i
SERD
may
be
potential
strategy
options.
Trial
registration:
registered
PROSPERO
(CRD42024518926).
Non-muscle-invasive
bladder
cancer
(NMIBC)
is
renowned
for
its
high
recurrence,
invasiveness,
and
poor
prognosis.
Consequently,
developing
new
biomarkers
risk
assessment
investigating
innovative
therapeutic
targets
postoperative
in
NMIBC
patients
are
crucial
to
aid
treatment
planning.
Differential
gene
expression
analysis
was
performed
using
multiple
Gene
Expression
Omnibus
(GEO)
datasets
identify
differentially
expressed
genes
(DEGs)
between
normal
tissue,
as
well
muscle-invasive
(MIBC).
Functional
enrichment
conducted
based
on
the
DEGs
identified.
Subsequently,
prognosis-related
were
selected
Kaplan–Meier
(KM)
Cox
regression
analysis.
The
Boruta
algorithm
utilized
further
screen
core
related
progression
aforementioned
genes.
Single-cell
clinical
correlation
studies
verify
their
across
various
stages
of
cancer.
To
investigate
link
immune
microenvironment,
single-sample
set
(ssGSEA)
utilized,
Receiver
Operating
Characteristic
(ROC)
KM
analyses
confirm
predictive
power
therapy
outcomes.
Machine
learning
(ML)
models
constructed
DepMap
dataset
predict
efficacy
inhibitors
treating
cancers.
prognostic
performance
evaluated
ROC
curve
An
online
prediction
tool
developed
provide
predictions.
Finally,
RT-qPCR,
CCK-8,
Transwell
assays
used
pro-tumor
effects
GINS2
A
total
70
identified,
among
which
11
obtained
through
analysis,
an
additional
8
COX
AURKB,
GINS2,
UHRF1
three
DEGs.
variable
indicated
that
promoted
infiltration
revealed
a
strong
positive
association
both
activated
CD4
T
cells
Type
2
helper
cells.
Two
random
forest
(RF)
effectively
effect
after
targeted
inhibition
AURKB
GINS2.
In
addition,
nomogram
undergoing
TURBT.
CCK8,
showed
growth
have
potential
enhance
management
transurethral
resection
tumor
(TURBT)
can
immunotherapy
response,
establishing
them
promising
targets.
Abstract
Metastatic
brain
tumors,
also
called
metastasis
(BM),
represent
a
challenging
complication
of
advanced
tumors.
Tumors
that
commonly
metastasize
to
the
include
lung
cancer
and
breast
cancer.
In
recent
years,
prognosis
for
BM
patients
has
improved,
significant
advancements
have
been
made
in
both
clinical
preclinical
research.
This
review
focuses
on
originating
from
We
briefly
overview
history
epidemiology
BM,
as
well
current
diagnostic
treatment
paradigms.
Additionally,
we
summarize
multiomics
evidence
mechanisms
tumor
occurrence
development
era
artificial
intelligence
discuss
role
microenvironment.
Preclinically,
introduce
establishment
models,
detailed
molecular
mechanisms,
cutting‐edge
methods.
is
primarily
treated
with
comprehensive
approach,
including
local
treatments
such
surgery
radiotherapy.
For
cancer,
targeted
therapy
immunotherapy
shown
efficacy,
while
monoclonal
antibodies,
tyrosine
kinase
inhibitors,
antibody–drug
conjugates
are
effective
BM.
Multiomics
approaches
assist
diagnosis
treatment,
revealing
complex
Moreover,
agents
often
need
cross
blood–brain
barrier
achieve
high
intracranial
concentrations,
small‐molecule
nanoparticles,
peptide
drugs.
Addressing
imperative.
Phytotherapy Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
ABSTRACT
In
Western
countries,
the
increase
in
consumption
of
soy‐derived
products
raises
population's
exposure
to
isoflavones.
These
molecules,
present
many
foods,
have
numerous
effects
on
body's
cells,
including
regulation
transcription
and
epigenetics,
cell
signaling,
cycle,
growth,
apoptosis,
oxidative
stress.
However,
despite
multitude
studies
conducted,
these
compounds,
it
remains
difficult
draw
definitive
conclusions
regarding
their
safety
or
dangerousness
diet.
Indeed,
some
epidemiological
highlight
health
benefits
consuming
isoflavone‐rich
notably
by
reducing
risk
certain
cancers.
several
conducted
models
show
that
molecules
can
negative
fate,
particularly
with
regard
proliferation
survival
mammary
tumor
cells.
Isoflavones
are
mainly
genistein,
daidzein,
formononetin,
biochanin
A.
belong
family
phytoestrogens,
which
capable
interacting
both
nuclear
estrogen
receptor,
ERα
ERβ,
trigger
agonistic
antagonistic
effects.
Due
estrogenic
properties,
isoflavones
suspected
promote
hormone‐dependent
cancers
such
as
breast
cancer.
This
suspicion
is
based
primarily
ability
bind
thereby
altering
signaling
pathways
control
growth.
study
results
sometimes
contradictory.
Some
suggest
may
protect
against
cancer
acting
selective
receptor
modulators,
while
others
potential
role
stimulating
review
explores
literature
isoflavones,
focusing
influence
ERα‐dependent
