Cell Proliferation, Год журнала: 2024, Номер unknown
Опубликована: Дек. 30, 2024
Overview of the functions and applications myokines MyoEVs.
Язык: Английский
Cell Proliferation, Год журнала: 2024, Номер 58(1)
Опубликована: Авг. 28, 2024
Abstract Interleukin‐12 (IL‐12) holds significant potential in cancer therapy; however, its clinical applicability is hindered by dose‐limiting toxicity. Delivery of the IL‐12 gene directly to tumours for constitutive expression a possible strategy enhance effectiveness while minimizing systemic In this study, we investigate red blood cell‐derived extracellular vesicles (RBCEVs) as carrier Il‐12 plasmid delivery. We demonstrate that RBCEVs can be loaded with minicircle encoding and delivered MB49 bladder cells expression. The transgenes from minicircles was significantly higher than parental plasmids. RBCEV‐mediated stimulated immune responses mouse splenocytes. Intratumoral delivery plasmid‐loaded suppressed tumour growth, promoted cell infiltration. conclusion, our study demonstrates promising an effective, safe redosable nucleic acid drug platform IL‐12.
Язык: Английский
Процитировано
3
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Июнь 3, 2025
Cancer treatment has been revolutionized by immunotherapy and nanomedicine, offering innovative strategies to overcome the tumor microenvironment (TME) complexities. However, challenges such as therapeutic resistance, off-target effects, immune suppression necessitate advanced delivery systems combination approaches. Recent advancements in nanoparticle-based therapies, biomimetic platforms, personalized provide promising solutions enhance efficacy while minimizing systemic toxicity. This review explores recent nanoparticle-mediated developments, highlighting optimize drug delivery, remodel TME, improve patient-specific outcomes. A comprehensive of literature focused on stimuli-responsive systems, nanoplatforms, The effectiveness therapies integrating physical immunological was also analyzed. Nanoparticle-mediated enables precise targeting controlled release, significantly improving Biomimetic nanoplatforms modulation bioavailability, immunotherapy, guided predictive biomarkers, tailors individual patients. Advanced nanomedicine strategies, including TME remodeling, targeted genome editing, immunotherapies, offer avenues for overcoming limitations conventional cancer treatments. Future research should nanoformulations, integrate multi-modal refine biomarker-driven personalization clinical
Язык: Английский
Процитировано
0
Expert Review of Anticancer Therapy, Год журнала: 2024, Номер unknown
Опубликована: Сен. 18, 2024
Urothelial carcinoma is a common malignancy affecting the urinary system, with spectrum of disease encompassing non-muscle invasive, muscle-invasive and metastatic disease. On background almost half century immunogenic management BCG, various immune checkpoint inhibitors, including durvalumab, have now demonstrated clinical efficacy in treatment urothelial carcinoma.
Язык: Английский
Процитировано
2
Cell Proliferation, Год журнала: 2024, Номер unknown
Опубликована: Дек. 30, 2024
Overview of the functions and applications myokines MyoEVs.
Язык: Английский
Процитировано
1