Clinical and Experimental Dermatology, Год журнала: 2022, Номер 47(5), С. 999 - 1002
Опубликована: Март 8, 2022
This case describes an unusual cutaneous presentation. Our patient had purpuric papules on the fingers and umbilicated nodules over elbows, interestingly, both lesion types showed similar histopathological features of necrobiotic granuloma with neutrophils.
Язык: Английский
Nature Reviews Rheumatology, Год журнала: 2023, Номер 19(6), С. 378 - 393
Опубликована: Май 9, 2023
Язык: Английский
Процитировано
139
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(18), С. 5996 - 5996
Опубликована: Сен. 15, 2023
Eosinophilic granulomatosis with polyangiitis (EGPA) causes necrotizing vasculitis and eosinophil-rich granulomatous inflammation in small- to medium-sized vessels, resulting multiple organ damage. EGPA is classified as an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, myeloperoxidase-ANCA detected approximately one-third of the patients. Conventional treatment relies on systemic glucocorticoids (GCs) combination cyclophosphamide when poor prognostic factors are present; however, dilemma between disease control drug-related adverse effects has long been a challenge. Recent studies have revealed that genetic background, pathophysiology, clinical manifestations differ ANCA-positive ANCA-negative patients; mepolizumab, interleukin (IL)-5 inhibitor, effective both groups, suggesting IL-5-eosinophil axis deeply involved pathogenesis EGPA. This review summarizes latest knowledge pathophysiology focuses roles eosinophils ANCA. We then introduce current recommendations accumulated evidence for mepolizumab Based unmet needs, we discuss potential future therapeutic strategies
Язык: Английский
Процитировано
16
BMC Ophthalmology, Год журнала: 2022, Номер 22(1)
Опубликована: Апрель 2, 2022
Abstract Background Kimura’s disease is a rare, benign, chronic inflammatory that presents as painless, solid masses mainly affecting the deep subcutaneous areas of head and neck, especially salivary glands, parotid glands nearby lymph nodes. It characterized by elevated peripheral blood eosinophil Immunoglobulin E (IgE) levels. Case presentation A 31-year-old Asian male presented with an orbital space-occupying lesion lasting for 1.5 years. Ten years prior, surgical excision bilateral fossa cubitalis groin was performed, pathological examination showed "lymphoproliferative disease". One year later, reappeared near sites; they grew slowly shrank after glucocorticoid treatment . At this point, admission examinations in proportion 13.4%, total IgE level 26,900.00 IU/mL, prurigo present on whole body, multiple palpable groin. The left eyeball exophthalmic. elbow mass excised, confirmed disease. Oral therapy taken tapering regularly. count returned to normal, gradually decreased, significantly, whole-body skin disappeared. Currently, patient has been stable condition eighteen months. Conclusion Our case provides novel insight should be involved differential diagnosis orbit also supports systemic regular valuable such condition, but close follow-up long-term observation are crucial.
Язык: Английский
Процитировано
17
Journal of Cutaneous Pathology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
The authors declare no conflicts of interest. Dr. Flowers has served as a principal investigator for Abbvie, Acelyrin, Clinuvel, Regeneron/Sanofi, and Sun Pharmaceuticals. He on advisory boards Argenx, Bristol-Myers Squibb, Janssen. Derebail consultant Amgen, Bayer, Merck, Forma Therapeutics, Novartis received honoraria from UpToDate. Data available request.
Язык: Английский
Процитировано
0
Dermatopathology, Год журнала: 2025, Номер unknown, С. 225 - 253
Опубликована: Янв. 1, 2025
Процитировано
0
Head and Neck Pathology, Год журнала: 2025, Номер 19(1)
Опубликована: Фев. 25, 2025
Abstract Background Dermatologic lesions with notable eosinophilic infiltration of the head and neck region represent a diverse group conditions, ranging from benign to malignant proliferations. Methods We performed comprehensive literature review focusing on dermatologic conditions that commonly present prominent infiltrate. Results This provides an overview common entities showing associated inflammatory infiltrates in this region, including epithelioid hemangioma, cellulitis (Wells syndrome), folliculitis, granulomatosis polyangiitis (Churg-Strauss granuloma faciale, Langerhans cell histiocytosis (LCH). Conclusion Eosinophils play key role pathogenesis these disorders, although exact mechanisms remain poorly understood. Accurate diagnosis is crucial for differentiating as they can share similar histologic features. aims enhance understanding improving diagnostic accuracy treatment strategies.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Human Pathology, Год журнала: 2023, Номер 140, С. 101 - 128
Опубликована: Март 30, 2023
Eosinophils are known to be present in inflammatory skin diseases, but their diagnostic utility is not well established. Upon review of the published status lesional eosinophils, several categories were identified. 1) Lesional eosinophils highly characteristic such that, absence, pathologist may question diagnosis. These include arthropod bite reactions and scabies, urticarial dermatitis, other eosinophilic dermatoses. 2) rare or absent, presence, pityriasis lichenoides, graft versus host disease, connective tissue disorders. 3) variable and, while some cases expected, required for drug reactions, atopic dermatitis allergic contact dermatitis. 4) expected seen a limited extent. lichen planus psoriasis.
Язык: Английский
Процитировано
6
Medicina, Год журнала: 2023, Номер 59(8), С. 1364 - 1364
Опубликована: Июль 25, 2023
Autoimmune heart disease is a non-random condition characterised by immune system-mediated aggression against cardiac tissue. Cardiac changes often exhibit nonspecific features and, if unrecognised, can result in fatal outcomes even among seemingly healthy young individuals. In the absence of reliable medical history, primary challenge lies differentiating between various cardiopathies. Numerous immunohistochemical and genetic studies have endeavoured to characterise distinct types cardiopathies, facilitating their differentiation during autopsy examinations. However, presence standardised protocol that forensic pathologists employ guide investigations would be beneficial. Hence, this summary aims present spectrum autoimmune including emerging insights such as SARS-CoV-2-induced proposes utilisation practical tools, blood markers, aid routine practice.
Язык: Английский
Процитировано
3
American Journal of Dermatopathology, Год журнала: 2021, Номер 44(5), С. 315 - 320
Опубликована: Ноя. 23, 2021
Eosinophilic granulomatosis with polyangiitis (EGPA) is rare vasculitis syndrome that involves the skin and other organ systems manifesting as asthma, eosinophilia, pulmonary infiltrates. The understanding of EGPA, previously known Churg-Strauss Syndrome, has continued to evolve from its earliest documentation in literature 1951. Herein, we review key historical advances diagnosis, classification, nomenclature EGPA have shaped our this protean disorder over time.
Язык: Английский
Процитировано
7