Small things matter: Lack of extra-islet beta cells in Type 1 diabetes

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Summary Recent 3D analyses reported abundant, small beta-cell-rich endocrine objects (EOs) in the human pancreas. Here, we assessed morphological parameters of >262,000 EOs pancreas sections from 220 donors with or without type 1 diabetes (T1D), ranging age and disease duration. We observe many insulin (Ins)+/glucagon (Gluc)-EOs diabetes. Their relative contribution to total area is greatest early life (0-2y) but reduces thereafter. Strikingly, show virtual absence Ins+Gluc- individuals T1D, where only medium large retain beta cells. also report a lower EO density especially diagnosed life. These findings suggest that extra-islet cells are impacted development their loss characteristic feature. This new understanding has important implications for defining beta-cell mass, which may inform future screening treatment strategies T1D. Highlights The present extensive 2D studies confirm extend recent pancreata, demonstrating 50% much smaller than classical islets Langerhans consist predominantly (Ins+). Small insulin+ comprise largest proportion childhood persist throughout course There shift towards larger size increasing age, most pronounced changes occurring first few years Ins+ virtually absent diabetes, while persisting larger, suggesting selective destruction EOs. Development particularly at an associated fewer adulthood. implies lack be detrimental generation

Язык: Английский

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Type 1 diabetes: immune pathology and novel therapeutic approaches

Diabetology International, Год журнала: 2024, Номер 15(4), С. 761 - 776

Опубликована: Сен. 11, 2024

Язык: Английский

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Basic science lays the foundation to success

Diabetic Medicine, Год журнала: 2023, Номер 40(12)

Опубликована: Ноя. 10, 2023

Язык: Английский

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