Cellular and Molecular Life Sciences, Год журнала: 2021, Номер 79(1)
Опубликована: Дек. 24, 2021
Язык: Английский
Diabetes & Metabolism Journal, Год журнала: 2022, Номер 46(2), С. 181 - 197
Опубликована: Март 25, 2022
Although diabetic kidney disease (DKD) remains the leading cause of end-stage eventually requiring chronic replacement therapy, prevalence DKD has failed to decline over past 30 years. In order reduce prevalence, extensive research been ongoing improve prediction onset and progression. most commonly used markers are albuminuria estimated glomerular filtration rate, their limitations have encouraged researchers search for novel biomarkers that could risk stratification. Considering is a complex process involves several pathophysiologic mechanisms such as hyperglycemia induced inflammation, oxidative stress, tubular damage, damage fibrosis, many capture one specific mechanism developed. Moreover, increasing use high-throughput omic approaches analyze biological samples include proteomics, metabolomics, transcriptomics emerged strong tool in biomarker discovery. This review will first describe recent advances understanding pathophysiology DKD, second, current clinical well status multiple potential with respect protein biomarkers, transcriptomics.
Язык: Английский
Процитировано
121
American Journal of Nephrology, Год журнала: 2021, Номер 52(8), С. 642 - 652
Опубликована: Янв. 1, 2021
Introduction: The nonsteroidal mineralocorticoid receptor (MR) antagonist finerenone and sodium-glucose cotransporter-2 (SGLT2) inhibitors have demonstrated clinical benefits in CKD patients with type 2 diabetes. Clinical data analyzing the potential value of a combination therapy are currently limited. We therefore investigated cardiorenal protection respective mono- preclinical model hypertension-induced end-organ damage. Methods: Cardiovascular (CV) morbidity mortality were studied hypertensive, N(ω)-nitro-L-arginine methyl ester-treated, renin-transgenic (mRen2)27 rats. Rats (10- to 11-week-old females, n = 13–17/group) treated once daily orally for up 7 weeks placebo, (1 3 mg/kg), empagliflozin (3 10 or low doses. Key outcome parameters included mortality, proteinuria, plasma creatinine uric acid, blood pressure, cardiac renal histology. Results: Placebo-treated rats 50% survival rate over course weeks. Drug treatment resulted variable degrees benefit, most prominently low-dose group benefit 93%. Monotherapies dose-dependently reduced while revealed an early, sustained, over-additive reduction proteinuria. Empagliflozin induced strong dose-dependent increase urinary glucose excretion which was not influenced by coadministration arm. Low-dose but monotherapies significantly acid after 6 Treatment decreased systolic pressure 5 There from kidney fibrosis vasculopathy both agents, more efficient than monotherapy dosages on histology parameters. Discussion/Conclusions: Nonsteroidal MR antagonism SGLT2 inhibition confer CV disease. Combination these independent modes action at efficacious important functional such as proteinuria markers including lesions determined histopathology, indicating combined use patient populations.
Язык: Английский
Процитировано
109
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Авг. 15, 2022
Diabetic nephropathy (DN) is a chronic, inflammatory disease affecting millions of diabetic patients worldwide. DN associated with proteinuria and progressive slowing glomerular filtration, which often leads to end-stage kidney diseases. Due the complexity this metabolic disorder lack clarity about its pathogenesis, it more difficult diagnose treat than other Recent studies have highlighted that immune system can inadvertently contribute pathogenesis. Cells involved in innate adaptive responses target due increased expression immune-related localization factors. Immune cells then activate pro-inflammatory response involving release autocrine paracrine factors, further amplify inflammation damage kidney. Consequently, strategies by targeting are currently under study. In light steady rise incidence, timely review summarizes latest findings role pathogenesis discusses promising preclinical clinical therapies.
Язык: Английский
Процитировано
103
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(15), С. 12378 - 12378
Опубликована: Авг. 3, 2023
Diabetes mellitus (DM) belongs to the category of socially significant diseases with epidemic rates increases in prevalence. Diabetic nephropathy (DN) is a specific kind kidney damage that occurs 40% patients DM and considered serious complication DM. Most modern methods for treatments aimed at slowing down progression DN have side effects do not produce unambiguous positive results long term. This fact has encouraged researchers search additional or alternative treatment methods. Hyperglycemia negative effect on renal structures due number factors, including activation polyol hexosamine glucose metabolism pathways, renin-angiotensin-aldosterone sympathetic nervous systems, accumulation advanced glycation end products insulin resistance endothelial dysfunction tissues. The above mechanisms cause development oxidative stress (OS) reactions mitochondrial dysfunction, which turn contribute DN. Modern antioxidant therapies involve various phytochemicals (food antioxidants, resveratrol, curcumin, alpha-lipoic acid preparations, etc.), are widely used only diabetes but also other systemic diseases. It been suggested therapeutic approaches target source reactive oxygen species may certain advantages terms nephroprotection from OS. review describes significance studies OS biomarkers pathogenesis analyzes reducing intensity prevention
Язык: Английский
Процитировано
49
Pharmaceutical Biology, Год журнала: 2024, Номер 62(1), С. 222 - 232
Опубликована: Фев. 15, 2024
Context Diabetic kidney disease (DKD) is a prominent complication arising from diabetic microangiopathy, and its prevalence renal impact have placed it as the primary cause of end-stage disease. Traditional Chinese Medicine (TCM) has distinct advantage multifaceted multilevel therapeutic attributes that show efficacy in improving clinical symptoms, reducing proteinuria, protecting function, slowing DKD progression. Over recent decades, extensive research explored mechanisms TCM for preventing managing DKD, with substantial studies endorse benefits compounds single agents medical intervention DKD.
Язык: Английский
Процитировано
19
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Ноя. 2, 2022
Diabetic nephropathy (DN) is the most common chronic kidney disease. Accumulation of glucose and metabolites activates resident macrophages in kidneys. Resident play diverse roles on diabetic injuries by releasing cytokines/chemokines, recruiting peripheral monocytes/macrophages, enhancing renal cell (podocytes, mesangial cells, endothelial cells tubular epithelial cells), macrophage-myofibroblast transition. The differentiation cross-talks ultimately result inflammation fibrosis DN. Emerging evidence shows that targeting suppressing macrophage activation/transition, macrophages-cell interactions may be a promising approach to attenuate In review, we summarized other DN, highlighted therapeutic potentials macrophages.
Язык: Английский
Процитировано
67
Nature Reviews Endocrinology, Год журнала: 2022, Номер 19(3), С. 151 - 163
Опубликована: Ноя. 29, 2022
Язык: Английский
Процитировано
53
Molecules, Год журнала: 2022, Номер 27(24), С. 9035 - 9035
Опубликована: Дек. 18, 2022
Diabetic nephropathy is manifested in more than 10% of people with diabetes. It a common cause kidney failure and end-stage disease. Understanding mechanisms underlying the initiation development diabetes-induced injuries will allow for effective methods prevention treatment wide-ranging complication diabetes, it necessary to discuss “weight” pro-inflammatory pathways molecules progress renal during A large spectrum participate different stages pathophysiological progression diabetic nephropathy, including cytokines, chemokines, their receptors, adhesion molecules, transcription factors. On other hand, known that one consequences hyperglycemia-induced ROS generation up-regulation cascades, which, turn, activate genes encoding cytokines-chemokines, growth factors, extracellular matrix proteins. proven fact variety plant secondary metabolites, such as tannins, flavonoids, polyphenols, demonstrate significant anti-diabetic, redox-modulating properties effectively modulate inflammatory response. Thus, this review discussing possible role phenols nephropathy.
Язык: Английский
Процитировано
42
Cureus, Год журнала: 2023, Номер unknown
Опубликована: Сен. 20, 2023
The complex and mutually influential connection between diabetes mellitus chronic kidney disease (CKD) is a significant focal point in the current healthcare landscape. Diabetes, medical condition characterized by elevated blood glucose levels resulting from impaired insulin action or secretion, has become global epidemic. It poses considerable challenges to systems affects millions of individuals worldwide. Concurrently, CKD, gradual decline function, persistent health challenge. This narrative review explores relationship these two conditions, shedding light on their implications for public health, clinical practice, biomedical research. correlation not merely coincidental. Diabetes recognized as risk factor with are considerably more vulnerable developing renal complications. Diabetic nephropathy, distinct type closely associated diabetes, end-stage disease. imperative implement efficient management strategies regulate sugar prevent potential damage. On other hand, may contribute development diabetes. kidneys filtering selectively reabsorbing necessary. In compromised such metabolism can give rise resistance As result, plays dual role both preserving function preventing who at risk. coexistence patient presents challenges. Achieving effective requires meticulous balance glycemic control preservation function. Failing maintain this delicate equilibrium lead cardiovascular complications subsequent hospitalizations. comprehensive aims thoroughly examine pathophysiological mechanisms that connect will provide insights into manifestations diagnostic methods, explore various approaches managing condition, discuss crucial nutrition, delve pharmacological interventions, emphasize importance education self-care, shed emerging research areas. addition impacting individual outcomes, reciprocal systems, socioeconomic landscapes, policy. Comprehending interaction making well-informed judgments, improving care, approach address interconnected issues
Язык: Английский
Процитировано
42
Journal of the American College of Cardiology, Год журнала: 2023, Номер 82(2), С. 161 - 170
Опубликована: Июль 1, 2023
Chronic kidney disease (CKD) and cardiovascular (CVD) have a significant inter-relationship in patients with diabetes. Controlling blood pressure, dyslipidemia, glucose levels is common treatment approach to managing CVD risk CKD diabetes; despite strict control, however, high residual remains. This review focuses on who require pharmacotherapy, whom new existing cardiorenal therapies (renin-angiotensin-aldosterone system inhibitors, sodium-glucose cotransporter-2 glucagon-like peptide-1 receptor agonists, nonsteroidal mineralocorticoid antagonists) differing mechanisms of action safety profiles can reduce beyond the outcomes achieved or glycemic control alone. Several guidelines been updated recently reflect evidence. Studies these agents used combination are ongoing, results awaited interest, hope that potential synergistic effects may lead further improvements outcomes.
Язык: Английский
Процитировано
40