Journal of Bone Metabolism, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 4, 2024
Recent studies have linked sarcopenia development to the hallmarks of diabetes, oxidative stress, and insulin resistance. The anti-oxidant sensitivityenhancing effects incretin-based therapies may provide a promising option for treatment sarcopenia. This review aimed unveil role stress resistance in pathogenesis explore potential benefits individuals with
Язык: Английский
Burns & Trauma, Год журнала: 2025, Номер 13
Опубликована: Янв. 1, 2025
Abstract Objective Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly impairs muscle regeneration following injuries, contributing to numerous complications and reduced quality of life. There an urgent need for therapeutic strategies can enhance alleviate these pathological mechanisms. In this study, we evaluate the efficacy W-GA nanodots, which are composed gallic acid (GA) tungstate (W6+), on in type (T2D)-induced injury, with focus their anti-inflammatory antioxidative effects. Methods This study synthesized ultrasmall nanodots were optimized improved stability bioactivity under physiological conditions. vitro assessments included cell viability, apoptosis, reactive oxygen species (ROS) generation, myotube differentiation C2C12 myoblasts hyperglycemic vivo, T2D was induced C57BL/6 mice, followed by injury treatment W-GA. Muscle repair, fibrosis, functional recovery assessed through histological analysis gait using CatWalk system. Results The enhanced proliferation, decreased ROS, apoptosis vitro. compared control group, W-GA-treated group exhibited notably regeneration, recovery. modulated inflammatory response oxidative stress diabetic tissues, facilitating regenerative dynamics function. Conclusions effectively counter mechanisms myopathy enhancing capacity reducing inflammation. nanomedicine approach offers promising avenue improving health overall life individuals suffering from T2D. However, further studies needed explore clinical applications long-term preventing complications.
Язык: Английский
Процитировано
0
OBM Geriatrics, Год журнала: 2025, Номер 09(01), С. 1 - 23
Опубликована: Фев. 20, 2025
Sarcopenia is more common in persons with type 2 diabetes mellitus (T2DM) than without diabetes. There overlap of some pathophysiologic features sarcopenia and T2DM. In addition, the risk for associated complications T2DM including renal disease, cardiovascular disease neuropathy. Glycemic control may have benefits on sarcopenia. The specific effects glucose lowering agents suggest that metformin, insulin, thiazolidinediones GLP1 receptor agonists favorable while SGLT2 inhibitors an adverse effect. However, RA’s been outcomes increased heart failure. Thus risk/benefit ratio overall key to selection agents. Nutrition guidelines generally align recommendations Data aerobic resistance exercise patients very limited, but data a benefit exercises.
Язык: Английский
Процитировано
0
BMC Endocrine Disorders, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 17, 2025
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Ноя. 11, 2024
Sarcopenia is a significant healthcare challenge in the aging population. Oxidative stress (OS) acknowledged to play pivotal role pathological progression of sarcopenia. Numerous studies have demonstrated that mitigating or eliminating OS can ameliorate manifestations associated with However, current clinical antioxidant therapies often fall short anticipated outcomes. This bibliometric analysis aims delineate prevailing research trends, thematic emphases, focal points, and developmental trajectories within domain sarcopenia, while also endeavoring explore prospective anti-oxidative strategies for future interventions.
Язык: Английский
Процитировано
3
Frontiers in Endocrinology, Год журнала: 2024, Номер 14
Опубликована: Янв. 16, 2024
Fat content in bones and muscles, quantified by magnetic resonance imaging (MRI) as a proton density fat fraction (PDFF) value, is an emerging non-invasive biomarker. PDFF has been proposed to indicate bone metabolic health among postmenopausal women. Premenopausal women with history of gestational diabetes (GDM) carry increased risk developing type 2 fractures. However, no studies have investigated the associations between GDM or paraspinal musculature (PSM), composed autochthonous muscle (AM) psoas muscle, which are responsible for moving stabilizing spine. This study aims investigate whether vertebral marrow PSM associated premenopausal A total 37 (mean age 36.3 ± 3.8 years) who were 6 15 months postpartum (n=19) without (n=18) underwent whole-body 3T MRI, including chemical shift encoding-based water-fat separation. The maps calculated bodies PSM. cross-sectional area (CSA) was obtained. Associations assessed using multivariable linear logistic regression models. significantly higher (GDM group) than (thoracic: median 41.55 (interquartile range 32.21-49.48)% vs. 31.75 (30.03-34.97)%; p=0.02, lumbar: 47.84 (39.19-57.58)% 36.93 (33.36-41.31)%; p=0.02). results remained significant after adjustment body mass index (BMI) (p=0.01-0.02). receiver operating characteristic curves showed optimal thoracic lumbar cutoffs at 38.10% 44.18%, respectively, differentiate (AUC 0.72 0.73, sensitivity 0.58, specificity 0.89). AM group (12.99 (12.18-15.90)% 10.83 (9.39-14.71)%; p=0.04) adjustments, while CSA similar groups (p=0.34). marrow, independent BMI. statistical association highlights potential biomarker assessment diabetes.
Язык: Английский
Процитировано
1
Diabetology & Metabolic Syndrome, Год журнала: 2024, Номер 16(1)
Опубликована: Сен. 16, 2024
Sarcopenia is a common complication of diabetes. Nevertheless, precise evaluation sarcopenia risk among patients with diabetes still big challenge. The objective this study was to develop nomogram model which could serve as practical tool diagnose in
Язык: Английский
Процитировано
1
Molecular and Cellular Biochemistry, Год журнала: 2024, Номер 479(12), С. 3195 - 3211
Опубликована: Фев. 22, 2024
Язык: Английский
Процитировано
0
Journal of Bone Metabolism, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 4, 2024
Recent studies have linked sarcopenia development to the hallmarks of diabetes, oxidative stress, and insulin resistance. The anti-oxidant sensitivityenhancing effects incretin-based therapies may provide a promising option for treatment sarcopenia. This review aimed unveil role stress resistance in pathogenesis explore potential benefits individuals with
Язык: Английский
Процитировано
0