VideoGIE, Год журнала: 2024, Номер 9(12), С. 530 - 532
Опубликована: Авг. 29, 2024
Язык: Английский
Metabolism and Target Organ Damage, Год журнала: 2025, Номер 5(1)
Опубликована: Март 21, 2025
With the backset of epidemic surge type 2 diabetes (T2D), obesity, and metabolic dysfunction-associated steatotic liver disease (MASLD), key role jejunal mucosa in development disorders, beyond its normal function nutrient absorption, has become increasingly appreciated. In humans, compared to non-diabetic controls, diabetic patients have hypertrophy, hyperplasia enteroendocrine cells, increased numbers cells enterocytes. Moreover, functional changes also been observed, including variations glucose transporters, enteric nerves, intestinal microbiota composition. Duodenal resurfacing (DMR) starts with assumption that mucosal interface will reset correct any abnormal signaling from duodenal will, therefore, result improved pancreatic endocrine tolerance owing restored surface. The endoscopic technique DMR involves hydrothermal ablation more superficial layers. Data reviewed indicate is a safe well-tolerated procedure, favorable outcomes on homeostasis among those T2D, body weight tests MASLD. Additional studies are therefore urgently needed ascertain, various surgical, medical choices, best precision medicine option fit individual patient
Язык: Английский
Процитировано
0
World Journal of Gastroenterology, Год журнала: 2025, Номер 31(16)
Опубликована: Апрель 25, 2025
Duodenal mucosal ablation (DMA) using irreversible electroporation (IRE) with a glucagon-like peptide-1 receptor agonist has been clinically shown to reduce liver lipid deposition in non-alcoholic fatty disease (NAFLD). However, the specific metabolic contributions of DMA IRE NAFLD remain unclear. To assess feasibility and effectiveness rat models. Seven-week-old male Sprague-Dawley rats underwent after 8 weeks on high-fat diet. Two post-treatment, duodenal tissues blood samples were collected. We evaluated differences wall structure, deposition, enteroendocrine, claudin, zonula ocludens-1 mucosa. could be safely performed without bleeding, perforation, or stenosis. The duodenum healed well 2 was characterized by slimmer villi, narrower shallower crypts, thicker myenterons compared sham-control setting. Liver reduced serum index parameters considerably improved these improvements independent food intake weight loss. In addition, enteroendocrine parameters, such as levels mucosa, differed between different settings group. By altering permeability, simple ameliorated rats.
Язык: Английский
Процитировано
0
Gastrointestinal Endoscopy, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Life, Год журнала: 2025, Номер 15(5), С. 796 - 796
Опубликована: Май 17, 2025
This study aimed to clarify the sequence characteristics and spatiotemporal expression patterns of insulin-like growth factor 1 receptor (IGF1R) gene in Alopex lagopus (Arctic fox), thereby addressing existing knowledge gap regarding IGF1R-mediated regulation this species. The findings establish a crucial foundation for subsequent investigations into correlation between Arctic fox traits. Specific primers were designed based on cDNA canine IGF1R (Accession No. XM_545828). full-length coding (CDS) (1617 bp, encoding 538 amino acids) was successfully cloned via RT-PCR. Phylogenetic analysis using Unweighted Pair Group Method with Arithmetic Mean (UPGMA) algorithm revealed 99% homology canine, confirmed their closest evolutionary relationship. Protein characterization showed that protein has molecular weight 60.62 kDa (theoretical isoelectric point pI = 5.15), containing one fibronectin type-III domain tyrosine kinase domain, classifying it as an acidic hydrophilic transmembrane protein. Phosphorylation site prediction identified 27 phosphorylation sites, secondary structures dominated by α-helices (26.39%) random coils (52.79%). displayed significant tissue-specific variations across 12 examined tissues foxes: highest levels testis, minimal stomach, no detectable duodenum. Spatiotemporal 2-, 4-, 6-month-old individuals, hepatic exhibited progressive increase, testicular reached peak at 6 months, skeletal muscle demonstrated transient upregulation peaking 4 months. These suggest may participate metabolism organ developmental processes during critical stages foxes through regulation.
Язык: Английский
Процитировано
0
Science Advances, Год журнала: 2025, Номер 11(22)
Опубликована: Май 30, 2025
Type 2 diabetes (T2D) and obesity are chronic metabolic diseases with global morbidity mortality. Decades of evidence from surgical endoscopic procedures bypassing the duodenum underscore duodenum’s critical role in regulating glycemia body weight. Although surgeries effective, their invasiveness, cost, scalability limit patient access. We developed an orally administered mucin complexing polymeric (MCP) drug, designed to replicate duodenal exclusion physiology. MCPs, intended have electrostatic covalent cross-linkages glycoproteins, form extended network structures resulting alteration mucus barrier properties. Selective targeting is achieved via pH-based activation chemistry. Following screening for physiochemical properties, pharmacokinetics, efficacy, GLY-200 emerged as lead drug candidate replicating physiology improved glycemia, reduced weight, modulation gut hormones rodent models. This targeted oral therapy holds promise treatment T2D by mimicking without invasiveness surgery or procedures.
Язык: Английский
Процитировано
0
Indian Journal of Gastroenterology, Год журнала: 2024, Номер 43(5), С. 1065 - 1067
Опубликована: Июль 11, 2024
Язык: Английский
Процитировано
0
VideoGIE, Год журнала: 2024, Номер 9(12), С. 530 - 532
Опубликована: Авг. 29, 2024
Язык: Английский
Процитировано
0